CLSI Publishes Guideline for the Collection, Transport, and Processing of Blood Specimens for Coagulation Assays.
WAYNE, Pa. -- The reliability and accuracy of coagulation coagulation (kōăg'ylā`shən), the collecting into a mass of minute particles of a solid dispersed throughout a liquid (a sol), usually followed by the precipitation or test results depend upon a variety of variables, including anticoagulant anticoagulant (ăn'tēkōăg`yələnt), any of several substances that inhibit blood clot formation (see blood clotting). volume and concentration, type of tube additive additive
In foods, any of various chemical substances added to produce desirable effects. Additives include such substances as artificial or natural colourings and flavourings; stabilizers, emulsifiers, and thickeners; preservatives and humectants (moisture-retainers); and , duration and temperature of specimen storage, and surface of containers used for specimen collection and storage.
Because of the many variables that can affect coagulation test results, Clinical and Laboratory Standards Institute (CLSI CLSI Clinical and Laboratory Standards Institute (Wayne, PA)
CLSI Cisco Link Services Interface , formerly NCCLS NCCLS National Committee for Clinical Laboratory Standards ) recently published an updated guideline, Collection, Transport, and Processing of Blood Specimens for Testing Plasma-Based Coagulation Assays and Molecular Hemostasis hemostasis /he·mo·sta·sis/ (he?mo-sta´sis) (he-mos´tah-sis)
1. the arrest of bleeding by the physiological properties of vasoconstriction and coagulation or by surgical means.
2. Assays; Approved Guideline--Fifth Edition (H21-A5), which provides procedures for collecting, transporting, and storing blood; processing blood specimens; storing plasma for coagulation testing; and general recommendations for performing the tests.
This document replaces the fourth edition approved guideline, H21-A4, which was published in 2003. Changes in this edition of the document include:
* revised transportation and storage guidelines for plasma-based hemostasis testing; and
* addition of information pertinent to the collection, transportation, and processing of specimens for molecular hemostasis assays.
The intended users of this guideline are laboratory and/or clinical personnel responsible for obtaining patient specimens and preparing samples for plasma-based or molecular coagulation testing. It is also aimed at manufacturers of products involved in specimen collection, storage, preparation, and testing of plasma-based or molecular hemostasis assays.
For additional information on CLSI or for further information regarding this release, visit our website at http://www.clsi.org or call +610.688.0100.
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