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CHECKUP COLORECTAL CANCER DRUG SHOWS PROMISE.



Byline: - Staff and Wire Reports

An experimental drug shows promising results when paired with chemotherapy in patients with advanced colorectal cancer, according to an early phase study from the UCLA UCLA University of California at Los Angeles
UCLA University Center for Learning Assistance (Illinois State University)
UCLA University of Carrollton, TX and Lower Addison, TX
 Jonsson Cancer Center. The drug, called Avastin, is designed to cut off a tumor's blood supply and could prove to be a less toxic and more effective tool in fighting cancer.

A tumor grows no larger than the size of a pinhead unless it establishes an independent blood supply to provide oxygen and nutrients. Researchers theorize the·o·rize  
v. the·o·rized, the·o·riz·ing, the·o·riz·es

v.intr.
To formulate theories or a theory; speculate.

v.tr.
To propose a theory about.
 that cutting off the new blood supply will starve and even kill the cancer.

Patients who received the drug with chemotherapy had better response rates and median survival times than did patients who received chemotherapy alone. With Avastin, the cancer also progressed more slowly and resulted in lower levels of the colon cancer marker in the blood.

The study was published in the Jan. 1 issue of the Journal of Clinical Oncology The Journal of Clinical Oncology is a medical journal published by the American Society of Clinical Oncology. The Journal was founded in 1983 and publishes original research and review articles on topics relating to cancer. It is published 3 times a month. .

RISK FACTOR?: A new study suggests that postmenopausal post·men·o·paus·al
adj.
Of or occurring in the time following menopause.


postmenopausal Change of life Gynecology adjective Referring to the time in ♀ when menstrual periods stop for ≥ 1 yr
 women who took combination estrogen-progestin hormone replacement therapy Hormone Replacement Therapy Definition

Hormone replacement therapy (HRT) is the use of synthetic or natural female hormones to make up for the decline or lack of natural hormones produced in a woman's body.
 experienced a modest increase in breast density - a known risk factor for breast cancer.

Researchers from UCLA, USC An abbreviation for U.S. Code.  and Wake Forest University examined digitized mammograms for 571 participants, comparing mammograms taken as a baseline to those taken a year after therapy. The estrogen-progestin therapy was associated with a 3 to 5 percent increase in breast density. The use of estrogen alone did not show a significant increase.

However, researchers caution that the link between the change in breast density as a result of hormone replacement therapy and the change in a woman's risk of developing breast cancer remains uncertain.

EARLY MAMMOGRAMS HELP: Middle-age women who have regular mammograms are 56 percent more likely to have a breast cancer detected at earlier stages than women who don't undergo screening.

While there is controversy about the efficacy of mammograms for women in their 40s, a University of Colorado University of Colorado may refer to:
  • University of Colorado at Boulder (flagship campus)
  • University of Colorado at Colorado Springs
  • University of Colorado at Denver and Health Sciences Center
  • University of Colorado system
 study has found that among more than 200 women diagnosed with breast cancer, those who had regular screening prior to their diagnosis were more likely to have the cancers found earlier, says study author Dr. Sandra Buseman, now a preventive medicine doctor for the Albany, N.Y., County Health Department.

There is debate about whether women with no family history of breast cancer should have regular mammograms in their 40s, Buseman says, because the breast tissue is denser, making detection trickier.

``It has been controversial. There is the risk of overdiagnosing, finding false-positives that lead to unnecessary biopsies and anxiety,'' Buseman adds. Conversely, a misreading MISREADING, contracts. When a deed is read falsely to an illiterate or blind man, who is a party to it, such false reading amounts to a fraud, because the contract never had the assent of both parties. 5 Co. 19; 6 East, R. 309; Dane's Ab. c. 86, a, 3, Sec. 7; 2 John. R. 404; 12 John. R.  of the dense tissue could mean missing a cancer.

``But this study supports the idea that screening is beneficial,'' she adds. ``Those who had undergone regular mammography mammography, diagnostic procedure that uses low-dose X rays to detect abnormalities in the breasts. The early diagnosis of breast cancer made possible by the routine use of mammography for screening women increases a woman's treatment alternatives and improves her  screening prior to being diagnosed with breast cancer showed the better outcome of being diagnosed at an early stage.''

Earlier detection of breast cancer is associated with a better long-term prognosis and more treatment options.
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Publication:Daily News (Los Angeles, CA)
Date:Jan 6, 2003
Words:487
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