CE test on LABORATORY-BASED INVESTIGATIONS OF IM AND EBV.MLO MLO Mycoplasma-like organism(s) and Northern Illinois University (NIU), DeKalb, IL, are co-sponsors in offering continuing education units (CEUs) for this issue's article on LABORATORY-BASED INVESTIGATIONS OF IM AND EBV EBV Epstein-Barr virus. EBV abbr. Epstein-Barr virus Epstein-Barr virus (EBV) A virus in the herpes family that causes mononucleosis. . CEUs or contact hours are granted by the College of Health and Human Sciences at NIU, which has been approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E.[R] program (Provider No. 0001) and by the American Medical Technologists Institute for Education (Provider No. 121019; Registry No. 0061). Approval as a provider of continuing education programs has been granted by the state of Florida (Provider No. JP0000496), and for licensed clinical laboratory scientists and personnel in the state of California (Provider No. 351). Continuing education credits awarded for successful completion of this test are acceptable for the ASCP ASCP American Society of Clinical Pathologists. Board of Registry Continuing Competence Recognition Program. After reading the article on page 10, answer the following test questions and send your completed test form to NIU along with the nominal fee of $20. Readers who pass the test successfully (scoring 70% or higher) will receive a certificate for 1 contact hour of P.A.C.E.[R] credit. Participants should allow four to six weeks for receipt of receipt of certificates. The fee for this continuing education test is $20. All feature articles published in MLO are peer-reviewed. Learning Objectives and CE test questions were prepared by Jennifer A. Lichamer, MT(ASCP), and reviewed by Jeanne M, Isabel, MSEd, CLSpH(NCA), associate professor, School of Allied Health Professions, College of Health and Human Sciences, Clinical Laboratory Sciences Program, DeKalb, IL. 1. The Epstein-Barr virus (EBV) contains all of the following features except a. linear double-stranded DNA DNA: see nucleic acid. DNA or deoxyribonucleic acid One of two types of nucleic acid (the other is RNA); a complex organic compound found in all living cells and many viruses. It is the chemical substance of genes. . b. linear single-stranded RNA RNA: see nucleic acid. RNA in full ribonucleic acid One of the two main types of nucleic acid (the other being DNA), which functions in cellular protein synthesis in all living cells and replaces DNA as the carrier of genetic . c. a structural envelope. d. a structural capsid capsid /cap·sid/ (kap´sid) the shell of protein that protects the nucleic acid of a virus; it is composed of structural units, or capsomers. cap·sid n. . 2. Infants infected with EBV are more likely to experience symptomatic infection than are EBV-infected adolescents. a. TRUE b. FALSE 3. Which of the following cell types are naturally infected with EBV? a. B lymphocytes b. T lymphocytes c. Epithelial cells d. Both a and c e. Both b and c 4. Which of the following syndromes do not present in a manner clinically similar to EBV infection? a. Salpingitis salpingitis /sal·pin·gi·tis/ (sal?pin-ji´tis) inflammation of an auditory or a uterine tube.salpingit´ic sal·pin·gi·tis n. Inflammation of a fallopian tube or eustachian tube. b. Streptococcal pharyngitis c. Viral meningitis d. Encephalitis 5. The circular episome episome (ĕp`ĭsōm), unit of genetic material composed of a series of genes that sometimes has an independent existence in a host cell and at other times is integrated into a chromosome of the cell, replicating itself along with the , located in the cellular envelope protein, is responsible for viral attachment to the host cell. a. TRUE b. FALSE 6. Infectious mononucleosis (IM) is caused by a. stimulation of B cells against the EBV infected cell. b. stimulation of Natural Killer cells natural killer cells, n.pl lymphocytes that are part of innate immunity that kill foreign substances and abnormal tissues. Decreased number or activi-ty has been linked to a number of diseases, including AIDS, cancer, chronic fatigue syndrome, against the EBV infected cell. c. CD4+ cytotoxic T cell cytotoxic T cell n. See killer cell. response against the EBV infected cell. d. CD8+ cytotoxic T cell response against the EBV infected cell. 7. EBV is the causative agent of chronic fatigue syndrome chronic fatigue syndrome (CFS), collection of persistent, debilitating symptoms, the most notable of which is severe, lasting fatigue. In other countries it is known variously as myalgic encephalomyelitis, chronic fatigue and immune dysfunction syndrome, and . a. TRUE b. FALSE 8. False negative results are most often observed in serology testing for EBV in which of the following populations? a. Children under age 14 b. Women aged 16 to 25 c. Men aged 16 to 25 d. Both men and women aged 16 to 25 9. Which of the following laboratory results are most likely to be observed in a patient with acute EBV? a. Lymphocytosis lymphocytosis /lym·pho·cy·to·sis/ (-si-to´sis) an excess of normal lymphocytes in the blood or an effusion. lym·pho·cy·to·sis n. with 5% atypical lymphocytes b. Lymphocytosis with 10% atypical lymphocytes c. Lymphocytosis with 20% atypical lymphocytes d. Lymphocytosis with 50% atypical lymphocytes 10. Anti-EBNA1 antibodies increase during convalescence during which stage of IM? a. Acute IM b. Chronic IM c. It rises during convalescence in both acute and chronic IM d. It rises during convalescence in neither acute nor chronic IM 11. Which of the following antibodies can cause cross reactions with rheumatoid factor when testing for EBV? a. Anti-VCA IgG b. Anti-VCA IgM c. Anti-EBNA1 d. Anti-EBNA2 12. Burkitt's lymphoma can be attributed to a co-infection between EBV infection and malaria due to Plasmodium vivax. a. TRUE b. FALSE 13. Malignancies due to EBV can be attributed to a translocation of the c-myc proto-oncogene from a. chromosome 8 to chromosome 2, the lambda light chain. b. chromosome 2 to chromosome 8, the heavy chain. c. chromosome 8 to chromosome 14, the heavy chain. d. chromosome 8 to chromosome 22, the kappa light chain. 14. Which disease is characterized by high levels of Anti-EA IgM and Anti-VCA antibodies and low levels of anti-EBNA antibodies? a. X-linked lymphoproliferative syndrome (XLPS) b. Nasopharyngeal carcinoma (NPC 1. (complexity) NPC - NP-complete. 2. (architecture) NPC - Next Program Counter. ) c. Burkitt's lymphoma d. Hodgkin's lymphoma 15. In type III latency, which of the following components is not observed? a. EBNA3 b. EBER c. SAP d. LMP 16. What percentage of the AIDS-associated Burkitt's lymphoma contains EBV genomes? a. 25% b. 30% c. 50% d. 60% 17. Histological diagnosis of Burkitt's lymphoma is based on all of the following factors except a. poorly differentiated lymphocytes. b. monoclonal cell tumors. c. polyclonal cell tumors. d. tumors of a B cell origin. 18. Which of the following is considered a risk factor with respect to nasopharyngeal carcinoma (NPC)? a. LMP4 b. EBNA2 c. HLA-A1 haplotype haplotype /hap·lo·type/ (-tip) the group of alleles of linked genes, e.g., the HLA complex, contributed by either parent; the haploid genetic constitution contributed by either parent. hap·lo·type n. d. HLA-A2 haplotype 19. Post-transplant lymphoproliferative disorder Post-transplant lymphoproliferative disorder (PTLD) is the name given to a group of B cell lymphomas occurring in immunosuppressed patients following organ transplant. Incidence/prevalence It is an uncommon condition occurring in 0. (PTLD) can be attributed to an acute infection with EBV following transplantation. a. TRUE b. FALSE 20. In suspected NPC, serum levels are not tested for which of the following components? a. IgA to VCA b. EBER c. EA d. EBNA-1 |
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