CCR5 and CXCR4 co-receptors in HIV infection.This article examined the central role played by co-receptor expression and usage in the transmission and pathogenic path·o·ge·net·ic (-j  -n t  k)adj. effects of HIV-1 infection of humans. The review contains a discussion of the HIV-1 phenotypic variants defined by their use of the CCR5 or CXCR4 co-receptors. How the different cellular tropism tropism /tro·pism/ (tro´pizm) the turning, bending, movement, or growth of an organism or part of an organism elicited by an external stimulus, either toward (positive t.) or away from (negative t.) the stimulus; used as a word element combined with a stem indicating the nature of the stimulus (e.g., phototropism) or material or entity for which an organism (or substance) shows a special affinity (e.g., neurotropism). patterns of these viral variants influence how and where HIV-1 replicates in vivo in vivo (Video In Video Out) Refers to a display adapter with analog video capture and analog video out (NTSC out) capabilities. See display adapter. /in vi·vo/ (ve´vo) [L.] within the living body.1. in vi·vo (v  v is also discussed, with emphasis on the thymus thy·mus·es and gut-associated lymphoid lymphoid /lym·phoid/ (lim´foid) resembling or pertaining to lymph or tissue of the lymphoid system.1. A lymphoid organ that is located in the superior mediastinum and lower part of the neck and is necessary in early life for the normal development of immunological function. 2. The thymus of a calf or lamb. lym·phoid (l mfoid tissues. The review also contains a consideration of the possible outcomes of the use of co-receptor antagonists as drugs to treat HIV-1 infection in vivo. Moore JP, Kitchen SG, Pugach P, Zack, JA. The CCR5 and CXCR4 coreceptors--central to understanding the transmission and pathogenesis of human immunodeficiency common variable immunodeficiency (CVID) a heterogeneous group of disorders characterized by hypogammaglobulinemia, decreased antibody production, and recurrent pyogenic infections, and often associated with hematologic and autoimmune disorders. Most patients appear to have an intrinsic defect of B cell differentiation. virus type 1 infection. AIDS Res Hum Retrovimses 2004;20:111-26. |
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