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CALGENE ISSUED BROAD ANTISENSE PATENT

 CALGENE ISSUED BROAD ANTISENSE PATENT
 DAVIS, Calif., April 22 /PRNewswire/ -- Calgene (NASDAQ: CGNE)


today announced that it has been granted U.S. Patent No. 5,107,065 entitled "Antisense Regulation of Gene Expression in Plant Cells." The patent covers the use of antisense technology to regulate genes in plants, and is not restricted by any limitation as to the type or species of plant cell. Antisense technology is the use of a reverse sequence of a specific gene to repress or "turn down" the expression of that gene.
 "This patent further validates Calgene's scientific leadership in the field of plant biotechnology," said Lloyd Kunimoto, Calgene's vice president of Corporate Development. "The broad significance of this patent is clear when one considers that the applications of antisense technology in plants include products as diverse as naturally decaffeinated coffee, carcinogen- and nicotine-free tobacco and higher quality fresh fruits, vegetables and cut flowers." Calgene intends to develop alliances to broadly exploit the use of antisense technology in crops other than Calgene's core crops -- tomato, canola and cotton. "Calgene can best realize the potential of this powerful technology by building a network of research and development and commercial partners," said Kunimoto.
 "The antisense patent will enable Calgene to strengthen its proprietary position in fresh tomatoes," said Kunimoto. "Each of the currently proven approaches to improve fresh tomato quality relies on the use of antisense technology. In particular, the use of ACC synthase to control tomato ripening requires antisense technology." Calgene has recently licensed the ACC synthase gene for use in tomato from the U.S. Department of Agriculture (U.S.D.A.).
 Calgene has also received patent allowance notification on related applications from Australia, New Zealand and Israel and is actively prosecuting patent protection in the other major countries. In February 1989, Calgene received the first U.S. plant antisense patent, covering the use of its FLAVR SAVR(TM) gene in tomato plants engineered to produce fruit with extended shelf life and enhanced flavor.
 Calgene is an agribusiness biotechnology company that is developing improved plant varieties and plant products for the seed, food and specialty chemical industries. The company has four operating subsidiaries: Ameri-Can Pedigreed Seed Co., Calgene Chemical, Calgene Fresh and Stoneville Pedigreed Seed Co.
 -0- 4/22/92
 /CONTACT: Daniel Wagster of Calgene Inc., 916-753-6313/
 (CGNE) CO: Calgene Inc. ST: California IN: SU:


DG-AC -- SF002 -- 1065 04/22/92 09:02 EDT
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Date:Apr 22, 1992
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