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Breakthrough Technology from Pall Increases Platelet Availability and Safety.


EAST HILLS, N.Y. -- Pall Corporation (NYSE NYSE

See: New York Stock Exchange
: PLL PLL - phase-locked loop ) announced today FDA FDA
abbr.
Food and Drug Administration


FDA,
n.pr See Food and Drug Administration.

FDA,
n.pr the abbreviation for the Food and Drug Administration.
 clearance to market the new Pall Acrodose(TM) PL System. This is the first whole blood derived platelet system for pre-storage pooling and testing of leukoreduced whole blood derived platelets resulting in a transfusion-ready product for the hospital. This unique product increases the availability of lifesaving platelets, enhances patient safety and is more cost-effective for the hospital.

"Adequate platelet availability in some communities can sometimes be a challenge," says Allan Ross, President of Pall Medical. "The Acrodose PL System provides an opportunity for blood centers and hospitals to increase the availability of bacterially tested, leukoreduced, and pooled whole blood derived platelets in a cost-effective manner."

Platelets are derived from donors in either a one-to-two hour procedure called apheresis apheresis (əfĕr`əsĭs), or hemapheresis (hē'məfĕr`əsĭs), any procedure in which blood is drawn from a donor or patient and a component (platelets, plasma, or white blood  or from standard whole blood collections. Apheresed platelets are limited by donor availability. They are also time consuming and capital intensive to obtain. Regardless of which collection process is used, bacterial contamination of platelets is the leading infectious cause of illness and death from a blood transfusion blood transfusion, transfer of blood from one person to another, or from one animal to another of the same species. Transfusions are performed to replace a substantial loss of blood and as supportive treatment in certain diseases and blood disorders. . Single donor platelets are tested for bacterial contamination using a sensitive culture detection method such as Pall's eBDS, enhanced bacterial system. Whole blood derived platelet units on the other hand are tested using less sensitive methods due to cost, product loss, and logistical constraints of testing several individual units to obtain a standard therapeutic dose. This has resulted in a disparity of test sensitivities as well as underutilization of a valuable blood resource.

The new Acrodose PL System enables blood centers to pool individual whole blood derived platelets prior to storage and conduct a single bacterial contamination test with its integrated Pall eBDS technology. Studies using the Pall eBDS System with pooled platelets resulted in greater than 99 percent detection of bacteria that can contaminate con·tam·i·nate
v.
1. To make impure or unclean by contact or mixture.

2. To expose to or permeate with radioactivity.



con·tam·i·nant n.
 platelets. With the new Acrodose PL System, blood centers will be able to provide hospitals and transfusion services with Acrodose(SM) Platelets, a transfusion-ready therapeutic dose of platelets that is both leukoreduced and bacteria tested with a highly sensitive culture based method. In turn, hospitals can reduce their handling costs by eliminating the need for further processing and testing.

"This is a seminal advance in blood safety and availability because hospitals now have assurance of access to more platelets that are safer than currently available whole blood derived platelets," says Roslyn Yomtovian, MD, Professor, Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio.

There are approximately 2.1 million transfusions annually in the U.S alone. On average, platelets are outdated and thrown away in five days making access to this lifesaving blood product precarious and costly, and especially problematic in emergency situations.

About Pall Corporation

Pall Corporation is the global leader in the rapidly growing field of filtration, separations and purification. Pall's business is organized around two broad markets: Life Sciences and Industrial. The Company provides leading-edge products to meet the demanding needs of customers in biotechnology, pharmaceutical, transfusion medicine transfusion medicine Blood banking A subspecialty of clinical pathology or internal medicine which is involved in Pt management through administration of blood cells and blood products including fresh-frozen plasma and cryoprecipitate; TM specialists are versant in , semiconductor, water purification, aerospace and broad industrial markets. Total revenues for fiscal 2005 were $1.9 billion. The Company headquarters are in East Hills, New York East Hills is a village in Nassau County, New York on the North Shore of Long Island. It is considered part of the Greater Roslyn area, which is anchored by the Village of Roslyn. As of the United States 2000 Census, the village population was 6,842.  with extensive operations throughout the world. Visit Pall at http://www.pall.com/.

This release contains "forward-looking statements" as defined in the Private Securities Litigation Reform Act The Private Securities Litigation Reform Act of 1995 (PSLRA) implemented several significant substantive changes affecting certain cases brought under the federal securities laws, including changes related to pleading, discovery, liability, class representation and awards fees and  of 1995. These statements are based on current Company expectations and are subject to risks and uncertainties which could cause actual results to differ materially. Such risks and uncertainties include, but are not limited to: fluctuations in foreign currency exchange rates; regulatory approval and market acceptance of new technologies; changes in product mix and product pricing and in interest rates and cost of raw materials; the Company's success in enforcing its patents and protecting its proprietary products and manufacturing techniques and its ability to achieve the savings anticipated from its cost reduction initiatives; global and regional economic conditions and legislative, regulatory and political developments; and domestic and international competition in the Company's global markets. Additional information regarding these and other factors is available on the Web at www.pall.com and is included in the Company's reports filed with the U.S. Securities and Exchange Commission. Copies of such reports can be obtained, without charge, at www.sec.gov.

Management uses certain non-GAAP measurements to assess Pall's current and future financial performance. The non-GAAP measurements do not replace the presentation of Pall's GAAP GAAP

See: Generally Accepted Accounting Principles


GAAP

See generally accepted accounting principles (GAAP).
 financial results. These measurements provide supplemental information to assist management in analyzing Pall's financial position and results of operations. Pall has chosen to provide this information to facilitate meaningful comparisons of past, present and future operating results and as a means to emphasize the results of on-going operations.

Editor's Notes:

Photos and additional information on the new Acrodose(TM) PL System can be found on http://www.pall.com/corporate_38334.asp

Several studies on the value of pre-storage pooled platelets will be presented at the upcoming AABB AABB American Association of Blood Banks.
AABB American Association of Blood Banks A professional, non-profit organization established in 1947 and dedicated to the education, formulation of standards, policy and other facets of
 annual meeting in Seattle, Washington at the Washington State Convention and Trade Center The Washington State Convention and Trade Center is a convention center located next to and over Interstate 5 in downtown Seattle, Washington, adjacent to Freeway Park. Planning for its construction began in 1982; construction began in 1985, and the center opened on June 18, 1988. , October 16, 2005 starting at 2:15 pm:

--Susan L. Wilkinson, EdD, Associate Director and Associate Professor Hoxworth Blood Center University of Cincinnati The University of Cincinnati is a coeducational public research university in Cincinnati, Ohio. Ranked as one of America’s top 25 public research universities and in the top 50 of all American research universities,[2]  Medical Center

--Laura Cooling, MD MS, Assistant Professor, Department of Pathology, Associate Medical Director, Transfusion Medicine, University of Michigan (body, education) University of Michigan - A large cosmopolitan university in the Midwest USA. Over 50000 students are enrolled at the University of Michigan's three campuses. The students come from 50 states and over 100 foreign countries.  

--Scott Murphy, MD, Medical Director, American Red Cross American Red Cross: see Red Cross. , Penn Jersey Division
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Publication:Business Wire
Geographic Code:1USA
Date:Oct 5, 2005
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