Bone problems: Overview article available.An overview of the growing problem of bone disease -- especially avascular necrosis (also called osteonecrosis osteonecrosis /os·teo·ne·cro·sis/ (os?te-o-ne-kro´sis) necrosis of a bone. os·te·o·ne·cro·sis n. Necrosis of bone. , or aseptic necrosis aseptic necrosis n. Necrosis occurring in the absence of infection. aseptic necrosis Avascular necrosis, osteonecrosis Orthopedics Death of bony tissue, usually due to ischemia. See Necrosis. ), which is requiring an increasing number of hip replacements in persons who have had AIDS and been on HAART HAART highly active antiretroviral therapy. HAART Highly active antiretroviral therapy, triple combination therapy AIDS The concurrent administration of 2 nucleoside reverse transcriptase inhibitors–eg, AZT and 3TC, and a protease for many years, was published in the April 2002 issue of POZ ("Hip to the Future," by Anne-christine d'Adesky, page 28-31 and 39). Avascular necrosis (which is different from osteopenia or osteoporosis, caused be loss of bone minerals) occurs when blood vessels Blood vessels Tubular channels for blood transport, of which there are three principal types: arteries, capillaries, and veins. Only the larger arteries and veins in the body bear distinct names. that supply the bone constrict con·strict v. To make smaller or narrower, especially by binding or squeezing. , cutting off blood supply and causing bone death. No one knows the cause, although there are many theories. The condition can be hard to diagnose early, and it is not known how many people are affected. Finding the Article Many AIDS service organizations and medical practices have copies of POZ, often available free or available for photocopying. Some newsstands may have copies. Unfortunately the Web site, www.poz.com, does not have the last six months of issues online (it does have back issues older than six months). If you want to get the article before it is online and cannot find a copy locally, you can purchase the April 2002 POZ by calling 800-9-READPOZ (toll-free from the U.S.), or 815-734-4151 (from anywhere). |
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