Bladder problem solving.
Interstitial cystitis interstitial cystitis: see cystitis. is an uncommon bladder disease diagnosed more often in women than in men. Its symptoms are pain and a frequent and urgent need to urinate urinate /uri·nate/ (u´ri-nat) to discharge urine.
To excrete urine.
to void urine. , but unlike the more common bacterially induced cystitis cystitis (sĭstī`tĭs), common acute or chronic inflammation of the urinary bladder. The disease occurs primarily in young women and frequently results from bacterial invasion of the urethra from the adjacent rectum, most commonly with , says urologist Edward Messing of the University of Wisconsin in Madison, its cause "is completely unknown at this time." A battery of treatments have been tried with little success.
In the past the chronic condition has been ascribed to emotional stress, but urologists now suspect a physiological cause. Researchers who believe the problems arise from the destruction of a protective mucous coating in the bladder have had some success using treatments that restore the lining. C. Lowell Parsons of the University of California The University of California has a combined student body of more than 191,000 students, over 1,340,000 living alumni, and a combined systemwide and campus endowment of just over $7.3 billion (8th largest in the United States). at San Diego has used an anticoagulant anticoagulant (ăn'tēkōăg`yələnt), any of several substances that inhibit blood clot formation (see blood clotting). that coasts the bladder wall, and at the recent American Urololgical Association (AUA AUA American Urological Association, see there ) meeting in Atlanta, Larrian Gillespire, who runs an interstitial cystitis clinic in the Los Angeles area, reported positive results with a three-drug regimen.
In initial trials using the anticoagulant on 24 people, Parsons found that 22 experienced a significant decrease in pain. At the AUA meeting, he described successful use of the drug, not yet approved for use in the United States, in five patients with a similar type of cystitis induced by radiation given to treat cervical carcinoma.
Gillespie believes damage to the mucous layer from bacteria, antibiotics, hormonal changes or surgery can cause interstitial cystitis by allowing urine to interact with bladder wall cells. She uses a combination of an anti-inflammatory drug, an alkaline agent to counteract the urine's acidity, and DMSO DMSO dimethyl sulfoxide.
Dimethyl sulfoxide; a colorless hygroscopic liquid obtained from lignin, used as a penetrant to convey medications into the tissues.
n. to carry the drugs into the cells. Of 145 patients treated, 108 became symptom free and another 21 achieved relief after receiving additional medication to block pain receptors.
Gillespie's therapy needs to be compared with a placebo, sustantiated and reproduced before it can be considered a cure, cautions Messing.