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Biovail Launches Glumetza to Canadian Physicians.


TORONTO -- Biovail Corporation (NYSE NYSE

See: New York Stock Exchange
:BVF BVF Biovail Corporation (stock symbol)
BVF Berufsverband der Frauenärzte eV (Muenchen, Germany)
BVF Bearing Versus Frequency
)(TSX TSX Toronto Stock Exchange (TSE before April, 2002)
TSX Transfer from Stack Pointer to Index
TSX True Space Extension
:BVF) announced today that it has officially launched Glumetza(TM) in Canada.

Developed in partnership with Depomed, Inc. (NASDAQ NASDAQ
 in full National Association of Securities Dealers Automated Quotations

U.S. market for over-the-counter securities. Established in 1971 by the National Association of Securities Dealers (NASD), NASDAQ is an automated quotation system that reports on
:DEPO DEPO Delegated Episcopal Pastoral Oversight
DEPO Devils Postpile National Monument (US National Park Service)
DEPO Defence Export Promotion Organization (Pakistan)
DEPO Double Even Pass Odd
) of Menlo Park, California Menlo Park is a city in San Mateo County, California in the United States of America. It is located at latitude 37°29' North, longitude 122°9' East. Menlo Park had 30,785 inhabitants as of the 2000 U.S. Census. , Glumetza(TM) is the first once-daily, extended-release formulation of metformin on the Canadian market. Glumetza(TM) is being launched by Biovail Pharmaceuticals Canada (BPC BPC British Potato Council
BPC Brewton-Parker College (Mt Vernon, GA)
BPC Bible Presbyterian Church
BPC Bangladesh Petroleum Corporation (Chittagong, Bangladesh)
BPC British Pharmaceutical Codex
), the Canadian sales and marketing division of Biovail Corporation. This launch further validates BPC's position as the number-one independent pharmaceutical commercial organization in the country.

"Hyperglycemia hyperglycemia: see diabetes.  is a major cause of many of the complications for people who have diabetes, so keeping your blood sugar as close to normal as possible not only helps you to feel better, but will help to reduce the risk of long-term complications," said Doug Herman, Vice-President and General Manager of BPC. "Metformin is the most prescribed oral medication for the treatment of Type II diabetes Type II diabetes
Type II diabetes is the most common form of diabetes and usually appears in middle aged adults. It is often associated with obesity and may be delayed or controlled with diet and exercise.

Mentioned in: Diabetic Ketoacidosis
. Providing Canadians with a once-daily metformin option to treat Type II diabetes is a great step toward enhanced patient adherence - and as a result, a great step forward toward helping to manage this disease."

Clinical data exists to show that reducing the frequency of daily dosing of oral diabetes medication can cause an improvement in patient compliance and metabolic control. Poor patient compliance to medications and dosing regimens represent a significant challenge to physicians in treating chronic disease - especially diabetes, due to the high number of medications that patients often have to take to control their disease. Glumetza(TM) offers a significant advantage to both physicians and patients by simplifying the dosage regimen of twice-a-day or three-times-a-day metformin to once a day.

In addition to physician calls to introduce Glumetza(TM), launch elements include sampling, marketing and other promotional activities.

About Glumetza(TM)

Glumetza(TM) is a once-daily extended-release formulation of metformin HCl and is intended to control diabetes mellitus - a condition characterized by high levels of blood glucose resulting from defects in insulin secretion, insulin activity or both. Glumetza(TM) is indicated for the control of hyperglycemia in metformin-responsive, stable, mild, non-ketosis prone maturity onset type of diabetes (Type II) which cannot be controlled by proper dietary management, exercise and weight reduction and when insulin therapy is not appropriate. Glumetza(TM) will be available in a 500mg extended-release tablet.

Safety Precautions

Patients are advised not to take Glumetza(TM) if they have kidney problems, heart failure that is treated with medicine, or have a condition called metabolic acidosis, including diabetic ketoacidosis, which should be treated with insulin.

Glumetza(TM) can cause a rare, but serious condition, called lactic acidosis. Patients should stop taking Glumetza(TM) and call their doctor right away if they feel very weak or tired, or have unusual muscle pain, trouble breathing, stomach pain with nausea and vomiting Nausea and Vomiting Definition

Nausea is the sensation of being about to vomit. Vomiting, or emesis, is the expelling of undigested food through the mouth.
, diarrhea or feel cold - especially in their arms and legs - or if they feel dizzy or lightheaded light·head·ed  
adj.
1. Faint, giddy, or delirious: lightheaded with wine.

2. Given to frivolity; silly.



light
, or have a slow or irregular heartbeat, or a medical condition suddenly changes.

The most common side effects of Glumetza(TM) include diarrhea, nausea, and upset stomach. In clinical trials, Glumetza(TM) has been shown to provide a similar tolerability profile to currently available metformin.

About Diabetes

Diabetes affects an estimated 2.25 million Canadians, and is increasing in epidemic proportions by approximately 60,000 new cases each year in Canada alone. Approximately 90% of diabetics suffer from Type II diabetes, the most common metabolic disease in the world and the seventh-deadliest disease in Canada. Diabetes is the leading cause of blindness, end-stage renal disease End-stage renal disease (ESRD)
Total kidney failure; chronic kidney failure is diagnosed as ESRD when kidney function falls to 5-10% of capacity.

Mentioned in: Chronic Kidney Failure

end-stage renal disease 
 and non-traumatic loss of limb, and can also lead to heart disease, stroke, high blood pressure and other serious conditions. In Canada, the public health cost of diabetes is estimated to be more than C$9 billion per year.

About Biovail Corporation

Biovail Corporation is a specialty pharmaceutical company, engaged in the formulation, clinical testing, registration, manufacture, and commercialization of pharmaceutical products utilizing advanced drug-delivery technologies. For more information about Biovail, visit the Company's Web site at www.biovail.com.

For further information, please contact Ken Howling at 905-286-3000 or send inquiries to ir@biovail.com.

"Safe Harbor" Statement Under the Private Securities Litigation Reform Act The Private Securities Litigation Reform Act of 1995 (PSLRA) implemented several significant substantive changes affecting certain cases brought under the federal securities laws, including changes related to pleading, discovery, liability, class representation and awards fees and  of 1995

To the extent any statements made in this release contain information that is not historical, these statements are forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. We have based these forward-looking statements on our current expectations and projections about future events. Our actual results could differ materially from those discussed in, or implied by, these forward-looking statements. Forward-looking statements are identified by words such as "believe", "anticipate", "expect", "intend", "plan", "will", "may" and other similar expressions. In addition, any statements that refer to expectations, projections or other characterizations of future events or circumstances are forward-looking statements. Forward-looking statements include, but are not necessarily limited to, risks and uncertainties, including the difficulty of predicting U.S. Food and Drug Administration and Canadian Therapeutic Products Directorate Therapeutic Products Directorate (TPD) is a Canadian federal authority that regulates pharmaceutical drugs and medical devices for human use, a role performed by the Food and Drug Administration in the United States.  approvals, acceptance and demand for new pharmaceutical products, the impact of competitive products and pricing, new product development and launch, reliance on key strategic alliances, tax rate assumptions, availability of raw materials and finished products, the regulatory environment, the outcome of legal proceedings, fluctuations in operating results and other risks detailed from time to time in the Company's filings with the Securities and Exchange Commission and the Ontario Securities Commission The Ontario Securities Commission (OSC) is a regulatory agency which administers and enforces securities legislation in the Canadian province of Ontario. The OSC is an Ontario Crown corporation which reports to the Ontario legislature through the Minister of Finance. . Biovail undertakes no obligation to update or revise any forward-looking statement.
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Publication:Business Wire
Geographic Code:1CANA
Date:Nov 29, 2005
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