Biotech/biomed companies: ranked by total employment.EXECUTIVE SUMMARY AMGEN AMGEN Applied Molecular Genetics (original meaning) Inc. tops the Business Journal's list of local Biotech/biomed companies. With 14,500 employees it is far larger than No. 2 Diagnostic Products Corp., a medical test maker with 2,440 employees. Private companies account for 16 of the largest 25 biotechnology/biomedical names, though only two made the top 10. Privately held Polypeptide polypeptide: see peptide. Laboratories Inc., which manufactures peptides, was No. 3, with 320 employees. At No. 9 is privately held Composite composite, alternate common name for Asteraceae or Compositae, the aster family. composite - aggregate Horizons Inc., with 110 employees. Only one company reported a decline in revenues: No. 5 Hemacare Corp., whose revenues were down $700,000 in 2004. Cytrx  This article or section is written like an .Please help [ rewrite this article] from a neutral point of view. Mark blatant advertising for , using . Corp., No. 21, reported the greatest percentage increase in revenues, jumping to $428,000 in 2004 from $100,000 in 2003. Those revenues are in the form of license fees because the company is still in the research and development stage. Overall, the 25 largest biotechnology biotechnology, the use of biological processes, as through the exploitation and manipulation of living organisms or biological systems, in the development or manufacture of a product or in the technological solution to a problem. and biomedical bi·o·med·i·cal adj. 1. Of or relating to biomedicine. 2. Of, relating to, or involving biological, medical, and physical sciences. companies headquartered in L.A. County have a combined workforce of 9,338 countywide coun·ty·wide adv. & adj. Throughout a whole county: found at locations countywide; a countywide search. Adj. 1. and 19,284 worldwide. THE PACESETTER AMGEN INC. THE Thousand Oaks-based company has eight products on the market and 21 products in clinical trial. Under chief executive Kevin KEVIN Keepers of the Eternal Vigilance of the Islamic Nation (fictional, from White Teeth by Zadie Smith) Sharer, product sales have been strong, led by Neupogen/Neulasta and Epogen E·po·gen A trademark for the drug epoetin alfa. epoetin alfa Epogen, Eprex (CA) (UK), Procrit Pharmacologic class: Recombinant human erythropoietin Therapeutic class: , which accounted for $2.9 and $2.6 billion of 2004 revenue, respectively. The two drugs fight neuropenia, a chemotherapy chemotherapy (kē'mōthĕr`əpē), treatment of disease with chemicals or drugs. One chemotherapeutic approach is the development of selectively toxic substances, i.e. side-effect side-effect - A language construct that modifies the state of the system. The most common side-effects are assignment, input and output. A language without side-effects is purely-functional - execution consists of the evaluation of an expression and all subexpressions are that causes a drop in white blood cell counts white blood cell count, n a diagnostic clinical laboratory test to determine the number and types of leukocytes present in a measured sample of blood. Overall the normal number of leukocytes ranges from 5000 to 10,000/mm3. . Epogen, Amgen's first product, debuted in 1989. It treats anemia anemia (ənē`mēə), condition in which the concentration of hemoglobin in the circulating blood is below normal. Such a condition is caused by a deficient number of erythrocytes (red blood cells), an abnormally low level of hemoglobin , especially in patients receiving dialysis dialysis (dīăl`ĭsĭs), in chemistry, transfer of solute (dissolved solids) across a semipermeable membrane. Strictly speaking, dialysis refers only to the transfer of the solute; transfer of the solvent is called osmosis. . Last year, Amgen acquired Tularik Inc., a Bay Area company that focuses on drug discovery related to cell signaling Cell signaling is part of a complex system of communication that governs basic cellular activities and coordinates cell actions. The ability of cells to perceive and correctly respond to their microenvironment is the basis of development, tissue repair, and immunity as well as and the control of gene expression. The acquisition added several clinical development candidates to its pipeline and more than doubled its number of metabolic met·a·bol·ic adj. Of, relating to, or resulting from metabolism. Metabolic Refers to the chemical processes of an organ or organism. research and pre-clinical programs. It also announced the formation of Amgen Ventures, a $100 million corporate venture fund designed to provide it access to early-stage biotechnology companies Top 100 Biotechnology Companies The following is a list of the top 100 biotechnology companies ranked by revenue. The first nine companies qualify for the list of the top 50 pharmaceutical companies. . A total of 35,000 patients were enrolled in Amgen clinical trials at the end of last year. An additional three products are in pre-clinical development Pre-clinical development is a stage in the development of a new drug that begins before clinical trials (testing in humans) can begin, and during which important safety and pharmacology data is collected. . The company, which employs 14,500 people worldwide, including 6,700 people at its headquarters, has invested at least 20 percent of product sales in research and development since 1994, including about $2 billion in 2004. [GRAPHICS OMITTED]
Rank Company Employees Revenues
* name * total (millions)
* address * L.A. County * 2004
* 2003
1 Amgen Inc. (1) 14,500 $10,600
1 Amgen Center Drive 6,700 $8,400
Thousand Oaks 91320
2 Diagnostic 2,440 443
Products Corp. 965 381
5210 Pacific
Concourse Drive
Los Angeles 90045
3 Polypeptide 320 WND
Laboratories Inc. 60 WND
365 Maple Ave.
Torrance 90503
4 Mannkind Corp. 315 N/A
28903 N. Paine Ave. 101 N/A
Valencia 91355
5 Hemacare Corp. 250 26.8
21101 Oxnard St. 175 27.5
Woodland Hills 91367
6 Staar Surgical Co. 247 51.7
1911 Walker Ave. 150 50.5
Monrovia 91016
7 North American 192 24.7
Scientific Inc. NA 14.7
20200 Sunburst St.
Chatsworth 91311
8 Iris International 182 43.7
Inc. NA 31.3
9172 Eton Ave.
Chatsworth 91311
9 Composite 110 12
Horizons Inc. same 12
1471 Industrial
Park St.
Covina 91722
100 24.3
10 Chad Therapeutics same 21.5
Inc.
21622 Plummer St.
Chatsworth 91311
11 American 100 WND
Bioscience Inc. same WND
2730 Wilshire Blvd.
Santa Monica 90403
12 Numotech Inc. 100 WND
9420 Reseda Blvd., same WND
Suite 504
Northridge 91324
13 Quantimetrix Corp. 60 10.5
2005 Manhattan same 10
Beach Blvd.
Redondo Beach 90278
14 Xencor Inc. 55 WND
111 W. Lemon Ave. same WND
Monrovia 91016
15 Amcyte Inc. 50 WND
2825 Santa Monica same WND
Blvd.,
Suite 200
Santa Monica 90404
16 Scigen Inc. 50 $5
333 E. Gardena Blvd. same $5
Gardena 90248
17 los Medical 35 5
2520 W. 237th St. same 5
Torrance 90505
18 Biocatalytics Inc. 30 WND
129 N. Hill Ave., same WND
Suite 103
Pasadena 91106
19 Gamma Medica Inc. 30 WND
19355 Business 29 WND
Center Drive,
Suite 8
Northridge 91324
20 Integrated Medical 25 WND
Systems Inc. same WND
1984 Obispo Ave.
Signal Hill 90788
21 Cytrx Corp. 25 0.5
11726 San Cicente 10 0.1
Blvd., Suite 650
Los Angeles 90049
22 Bioagri Corp. 20 3
17711 Rowland St. same 0
City of Industry
91748
23 Diasol Inc. 18 WND
13212 Raymer St. 12 WND
North Hollywood
91605
24 Neurion 15 WND
Pharmaceuticals Inc. same WND
180 N. Vinedo Ave.
Pasadena 91107
25 Biodiscovery Inc. 15 WND
100 N. Sepulveda 12 WND
Blvd., Suite 1230
El Segundo 90245
Rank Company Business Focus Products
* name * on market
* address * in clinical trial
* in development
1 Amgen Inc. (1) human therapeutics 8
1 Amgen Center Drive 21
Thousand Oaks 91320 3
2 Diagnostic blood tests and 100+
Products Corp. instruments N/A
5210 Pacific N/A
Concourse Drive
Los Angeles 90045
3 Polypeptide peptide 30
Laboratories Inc. manufacturer for N/A
365 Maple Ave. pharmaceutical N/A
Torrance 90503 industry
4 Mannkind Corp. therapeutic 0
28903 N. Paine Ave. products for 1
Valencia 91355 diabetes and 3
cancer
5 Hemacare Corp. blood products and 12
21101 Oxnard St. therapeutic blood 0
Woodland Hills 91367 services 0
6 Staar Surgical Co. ophthalmic devices 30
1911 Walker Ave. 3
Monrovia 91016 3
7 North American radiation therapy NA
Scientific Inc. treatment NA
20200 Sunburst St. equipment NA
Chatsworth 91311
8 Iris International urinalysis NA
Inc. equipment NA
9172 Eton Ave. NA
Chatsworth 91311
9 Composite carbon fiber/ 200
Horizons Inc. composite medical 5
1471 Industrial devices 5
Park St.
Covina 91722
oxygen therapy 18
10 Chad Therapeutics products and sleep 1
Inc. disorder 5
21622 Plummer St. diagnosis/
Chatsworth 91311 treatment
11 American proprietary drug 1
Bioscience Inc. development 45
2730 Wilshire Blvd. N/A
Santa Monica 90403
12 Numotech Inc. wound care 4
9420 Reseda Blvd., management and 2
Suite 504 treatment 2
Northridge 91324
13 Quantimetrix Corp. clinical 40
2005 Manhattan diagnostic product N/A
Beach Blvd. development N/A
Redondo Beach 90278
14 Xencor Inc. biotherapeutic 0
111 W. Lemon Ave. technologies and 0
Monrovia 91016 products 4
15 Amcyte Inc. adult stem cell 0
2825 Santa Monica therapy for 1
Blvd., diabetes 1
Suite 200
Santa Monica 90404
16 Scigen Inc. medical waste 100+
333 E. Gardena Blvd. disposal 5
Gardena 90248 20
17 los Medical optical technology 10
2520 W. 237th St. for medical 12
Torrance 90505 equipment 12
18 Biocatalytics Inc. enzymes for 0
129 N. Hill Ave., chemical synthesis 7
Suite 103 of drug 10
Pasadena 91106 intermediate
compounds
19 Gamma Medica Inc. manufacturer of 5
19355 Business medical imaging 1
Center Drive, systems 4
Suite 8
Northridge 91324
20 Integrated Medical integrated 1
Systems Inc. critical care 0
1984 Obispo Ave. medical and data 2
Signal Hill 90788 products/services
21 Cytrx Corp. biopharmaceutical 0
11726 San Cicente research and 2
Blvd., Suite 650 development 7
Los Angeles 90049
22 Bioagri Corp. chicken egg- 0
17711 Rowland St. derived human 0
City of Industry therapeutic 6
91748 proteins
23 Diasol Inc. dialysis products 4
13212 Raymer St. manufacturer 0
North Hollywood 2
91605
24 Neurion ion channel drug 0
Pharmaceuticals Inc. discovery 0
180 N. Vinedo Ave. 2
Pasadena 91107
25 Biodiscovery Inc. functional genomic 4
100 N. Sepulveda research and 0
Blvd., Suite 1230 diagnostics 0
El Segundo 90245 software
development
Rank Company Profile Top Local
* name * year established Executive
* address * ownership * name
* Web site * title
* phone
1 Amgen Inc. (1) 1980 Kevin Sharer
1 Amgen Center Drive public ceo
Thousand Oaks 91320 amgen.com (805) 447-4587
2 Diagnostic 1971 Michael Ziering
Products Corp. public ceo
5210 Pacific dpcweb.com (310) 645-8200
Concourse Drive
Los Angeles 90045
3 Polypeptide 1996 Jane Salik
Laboratories Inc. private president
365 Maple Ave. polypeptide.com (310) 782-3569
Torrance 90503
4 Mannkind Corp. 1991 Alfred Mann
28903 N. Paine Ave. public ceo
Valencia 91355 mannkindcorp.com (661) 775-5300
5 Hemacare Corp. 1978 Judi Irving
21101 Oxnard St. public ceo, president
Woodland Hills 91367 hemacare.com (818) 226-1968
6 Staar Surgical Co. 1982 David Bailey
1911 Walker Ave. public ceo, president
Monrovia 91016 staar.com (626) 303-7902
7 North American 1990 L. Michael Cutter
Scientific Inc. public ceo, president
20200 Sunburst St. nomos.com (818) 734-5200
Chatsworth 91311
8 Iris International 1979 Cesar Garcia
Inc. public ceo, president
9172 Eton Ave. proiris.com (818) 709-1244
Chatsworth 91311
9 Composite 1981 Jeff Hynes
Horizons Inc. private president
1471 Industrial chi-covina.com (626) 331-0861
Park St.
Covina 91722
1982 Earl Yager
10 Chad Therapeutics public ceo, president
Inc. chadtherapeutics.com (818) 882-0883
21622 Plummer St.
Chatsworth 91311
11 American 1994 Dr. Patrick
Bioscience Inc. private Soon-Shiong
2730 Wilshire Blvd. N/A chairman, ceo,
Santa Monica 90403 president
(310) 883-1300
12 Numotech Inc. 1990 Dr. Robert Felton
9420 Reseda Blvd., private ceo, president
Suite 504 numotech.com (877) 686-6832
Northridge 91324
13 Quantimetrix Corp. 1974 Robert W. Ban
2005 Manhattan private chairman,
Beach Blvd. 4qc.com president
Redondo Beach 90278 (310) 536-0006
14 Xencor Inc. 1997 Bassil Dahiyat
111 W. Lemon Ave. private ceo, president
Monrovia 91016 xencor.com (626) 305-5900
15 Amcyte Inc. 1991 Terrence
2825 Santa Monica private Soon Shiong
Blvd., amcyte.com chairman, ceo
Suite 200 (310) 264-7768
Santa Monica 90404
16 Scigen Inc. 1992 Steven Wheeler
333 E. Gardena Blvd. private president
Gardena 90248 scigenus.com (310) 324-6576
17 los Medical 2005 Fred Held
2520 W. 237th St. private ceo, president
Torrance 90505 intopsys.com/medical (310) 530-7130
18 Biocatalytics Inc. 1996 David Rozzell
129 N. Hill Ave., private ceo, president
Suite 103 biocatalytics.com (626) 585-9797
Pasadena 91106
19 Gamma Medica Inc. 2001 Bradley E. Patt
19355 Business private ceo, president
Center Drive, gammamedica.com (818) 709-2468
Suite 8
Northridge 91324
20 Integrated Medical 1999 Steve Alexander
Systems Inc. private president, coo
1984 Obispo Ave. lstat.com (562) 498-1776
Signal Hill 90788
21 Cytrx Corp. 1985 Steven A. Kriegsman
11726 San Cicente public ceo, president
Blvd., Suite 650 cytrx.com (310) 826-5648
Los Angeles 90049
22 Bioagri Corp. 1999 Ken Wang
17711 Rowland St. private president
City of Industry bioagricorp.com (626) 810-2823
91748
23 Diasol Inc. 1998 Monica Abeles
13212 Raymer St. private president
North Hollywood diasol.com (818) 255-1800
91605
24 Neurion 2002 William L. Robbins
Pharmaceuticals Inc. private chairman, ceo,
180 N. Vinedo Ave. neurionpharma.com president
Pasadena 91107 (626) 583-5020
25 Biodiscovery Inc. 1997 Soheil Shams
100 N. Sepulveda private president
Blvd., Suite 1230 biodiscovery.com (310) 414-8100
El Segundo 90245
WND -- Would Not Disclose
NA -- Not Available
N/A -- Not Applicable
(1) Amgen Inc. is based in Ventura County.
Note: Information for this list was provided by the companies
themselves. Companies are L.A. County-based, except Amgen.
Companies are ranked by total number of employees.
To the best of our knowledge, this information is accurate as of
press time. While every effort is made to ensure the accuracy and
thoroughness of the list, omissions and typographical errors sometimes
occur. Please send corrections or additions on company letterhead to
the Research Department, Los Angeles Business Journal, 5700 Wilshire
Blvd., Suite 170, Los Angeles 90036. [c] 2005 Los Angeles Business
Journal. This list may not be reprinted in whole or in part without
prior written permission from the editor. Reprints are available from
Wright's Reprints, (877) 652-5295.
Researched by David Nusbaum
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