Biotech/biomed companies: ranked by total employment.EXECUTIVE SUMMARY AMGEN AMGEN Applied Molecular Genetics (original meaning) Inc. tops the Business Journal s list of locally based biotech/biomed companies. With 16,500 employees, it is far larger than No. 2 Diagnostic Products Corp., a medical test maker with 2,600 employees. Private companies account for 15 firms on the list, though only two made the top 10. Privately held Discus Dental dental /den·tal/ (den´t'l) pertaining to a tooth or teeth. den·tal adj. 1. Of, relating to, or for the teeth. 2. Of, relating to, or intended for dentistry. and PolyPeptide polypeptide: see peptide. Laboratories Inc. rank Nos. 4 and 6 with 480 and 325 employees, respectively. Abraxis Abraxis Kits is a company based in Warminster Township, Pennsylvania that designs, develops and manufactures immunochemistry-based testing products for scientific research and industrial manufacturing. BioScience bioscience /bio·sci·ence/ (-si´ens) the study of biology wherein all the applicable sciences (physics, chemistry, etc.) are applied. bi·o·sci·ence n. See life science. Inc., No. 3, was newly created last year as the result of a merger between two companies originally formed by billionaire Patrick Soon-Shiong. American American, river, 30 mi (48 km) long, rising in N central Calif. in the Sierra Nevada and flowing SW into the Sacramento River at Sacramento. The discovery of gold at Sutter's Mill (see Sutter, John Augustus) along the river in 1848 led to the California gold rush of Pharmaceutical Partners Inc. and Santa Monica-based American Bioscience Inc. merged in a deal valued at $4.1 billion when it was announced. Abraxis combines American Pharmaceutical's record in manufacturing generic drugs generic drug, a drug sold or prescribed under the nonproprietary name of its active ingredients or under a generally descriptive name rather than under a brand or trade name. , plus a proprietary cancer treatment called Abraxane, with American BioScience's biotech bi·o·tech n. Informal Biotechnology. biotech Noun short for biotechnology Noun 1. drug pipeline. Overall, the 25 largest biotechnology biotechnology, the use of biological processes, as through the exploitation and manipulation of living organisms or biological systems, in the development or manufacture of a product or in the technological solution to a problem. and biomedical bi·o·med·i·cal adj. 1. Of or relating to biomedicine. 2. Of, relating to, or involving biological, medical, and physical sciences. companies headquartered in L.A. County have a combined workforce of 23,624 worldwide. They have 1,628 products on the market with 42 in clinical trials. --David Nusbaum Nusbaum is a village in the district Bitburg-Prüm in Rhineland-Palatinate, Germany, situated in the southern part of the Eifel. Links
THE PACESETTER AMGEN INC. THOUSAND Oaks-based Amgen Inc. has 16,500 employees, up 2,000 from the previous year. Under Chief Executive Kevin KEVIN Keepers of the Eternal Vigilance of the Islamic Nation (fictional, from White Teeth by Zadie Smith) Sharer, product sales have been strong. In the first quarter of 2006, Amgen reported net income of $1 billion on revenues of $3.2 billion, the first time quarterly earnings surpassed $1 billion. Product sales were led by Aranesp, Neulasta and Epogen E·po·gen A trademark for the drug epoetin alfa. epoetin alfa Epogen, Eprex (CA) (UK), Procrit Pharmacologic class: Recombinant human erythropoietin Therapeutic class: . The three injectable in·ject·a·ble adj. Capable of being injected. Used of a drug. n. A drug or medicine that can be injected. drugs fight anemia anemia (ənē`mēə), condition in which the concentration of hemoglobin in the circulating blood is below normal. Such a condition is caused by a deficient number of erythrocytes (red blood cells), an abnormally low level of hemoglobin , infection and arthritis arthritis, painful inflammation of a joint or joints of the body, usually producing heat and redness. There are many kinds of arthritis. In its various forms, arthritis disables more people than any other chronic disorder. . Epogen, Amgen's first product, debuted in 1989. It treats anemia, especially in patients receiving dialysis dialysis (dīăl`ĭsĭs), in chemistry, transfer of solute (dissolved solids) across a semipermeable membrane. Strictly speaking, dialysis refers only to the transfer of the solute; transfer of the solvent is called osmosis. . Last year, Amgen announced the acquisition of Fremont-based Abgenix Inc. for $2.2 billion. The company specializes in the discovery, development and manufacture of human therapeutic antibodies Antibodies Specialized cells of the immune system which can recognize organisms that invade the body (such as bacteria, viruses, and fungi). The antibodies are then able to set off a complex chain of events designed to kill these foreign invaders. . The acquisition of Abgenix provides Amgen with full ownership of one of its most important advanced pipeline products, panitumumab Panitumumab (ABX-EGF) is a fully human monoclonal antibody specific to the EGF receptor (see illustration)[1]. It was FDA approved for the first time in September 2006, for the "the treatment of EGFR-expressing metastatic colorectal cancer with disease progression" . Co-developed by Amgen and Abgenix, panitumumab is the first fully human monoclonal antibody monoclonal antibody, an antibody that is mass produced in the laboratory from a single clone and that recognizes only one antigen. Monoclonal antibodies are typically made by fusing a normally short-lived, antibody-producing B cell (see immunity) to a fast-growing that targets a protein that plays an important role in cancer. Panitumumab is being evaluated in clinical trials as both a single therapy and in combination with other agents for the treatment of colorectal co·lo·rec·tal adj. Relating to the colon and the rectum, or to the entire large bowel. colorectal pertaining to or of the nature of the colon and the rectum. , lung, kidney and other cancers. Founded in 1980, the company reported $3.7 billion in net income on $12.4 billion revenue in 2005. Amgen had nine products currently on the market with 22 products in clinical trial and 16 in pre-clinical development Pre-clinical development is a stage in the development of a new drug that begins before clinical trials (testing in humans) can begin, and during which important safety and pharmacology data is collected. as of January January: see month. . --David Nusbaum
Rank Company (Ranking in 2005) Employees
* name * total
* address * L.A. County
* Web site
1 Amgen Inc. (1) 16,500
1 Amgen Center Drive N/A
Thousand Oaks 91320
amgen.com
2 Diagnostic Products Corp. (2) 2,600
5210 Pacific Concourse Drive 900
Los Angeles 90045
dpcweb.com
3 Abraxis BioScience Inc. 1,500
11777 San Vicente Blvd. 125
Los Angeles 90049
abraxisbio.com
4 Discus Dental 480
8550 Higuera St. 300
Culver City 90232
discusdental.com
5 MannKind Corp. (4) 428
28903 N. Avenue Paine 111
Valencia 91355
mannkindcorp.com
6 PolyPeptide Laboratories Inc. (3) 325
365 Maple Ave. 65
Torrance 90503
polypeptide.com
7 Hemacare Corp. (5) 275
21101 Oxnard St. 185
Woodland Hills 91367
hemacare.com
8 Staar Surgical Co. (6) 267
1911 Walker Ave. N/A
Monrovia 91016
staar.com
9 Iris International Inc. (8) 246
9172 Eton Ave. 120
Chatsworth 91311
proiris.com
10 North American Scientific Inc. (7) 166
20200 Sunburst St. 56
Chatsworth 91311
nasmedical.com
11 Chad Therapeutics Inc. (10) 129
21622 Plummer St. N/A
Chatsworth 91311
chadtherapeutics.com
12 Composite Horizons Inc. (9) 124
1471 Industrial Park St. 124
Covina 91722
chi-covina.com
13 Numotech Inc. (12) 100
9420 Reseda Blvd., Suite 504 N/A
Northridge 91324
numotech.com
14 Evergreen Scientific 80
2254 E. 49th St. 80
Los Angeles 90058
www.evergreensci.com
15 Xencor Inc. (14) 70
111 W. Lemon Ave. 70
Monrovia 91016
xencor.com
16 Quantimetrix Corp. (13) 60
2005 Manhattan Beach Blvd. 60
Redondo Beach 90278
4gc.com
17 Gamma Medica-Ideas USA (19) 42
19355 Business Center Drive, Suite 8 39
Northridge 91324
gm-ideas.com
18 Radlink 40
2400 Marine Ave. 40
Redondo Beach 90278
eradlink.com
19 Medical Science Licensing Inc. (17) 35
2520 W. 237th St. 35
Torrance 90505
intopsys.com
20 Amcyte Inc. (15) 32
2825 Santa Monica Blvd., Suite 200 32
Santa Monica 90404
amcyte.com
21 Biocatalytics Inc. (18) 30
129 N. Hill Ave., Suite 103 N/A
Pasadena 91106
biocatalytics.com
22 Integrated Medical Systems Inc. (20) 29
1984 Obispo Ave. 29
Signal Hill 90755
Istat.com
23 CytRx Corp. (21) 26
11726 San Vicente Blvd., Suite 650 9
Los Angeles 90049
cytrx.com
24 Scigen Inc. (16) 25
333 E. Gardena Blvd'. 25
Gardena 90248
scigenus.com
25 ARS Enterprises Inc. 15
12900 Lakeland Road 13
Santa Fe Springs 90670
rely-ars.com
Rank Revenues Business Focus
(in millions)
* 2005
* 2004
1 $12,430 human therapeutics
$10,550
2 481 blood tests and instruments
447
3 519 integrated global biopharmaceutical,
405 specialty injectable products for cancer
and other diseases
4 131 dental products
904
5 0 therapeutic products for diabetes and
0 cancer
6 N/A manufactures peptides for
N/A pharmaceutical industry
7 31 blood products and therapeutic blood
27 services
8 51 eye care products
52
9 62 urinalysis and molecular diagnostics
44
10 32 radiation therapy treatment products
25
11 24 products for oxygen therapy and sleep
22 disorders diagnosis/treatment
12 14 carbon fiber/composite medical
12 products
13 N/A wound care management and treatment
N/A
14 N/A manufactures laboratory disposables
N/A
15 5 biotherapeutics
2
16 11 develops, manufactures and distributes
11 clinical diagnostic products
17 N/A imaging systems used in medical
N/A research, clinical medicine, and safety
and security
18 3 medical imaging equipment
2
19 5 licensing and developing optical science
5
20 N/A adult stem cell therapy for diabetes
N/A
21 N/A biocatalysis for the synthesis of chiral
N/A drug intermediates and production of
drug metabolites
22 6 integrated medical and data products
6 and services for critical care
23 N/A biopharmaceutical research and
N/A development
24 20 FDA device, special chemicals
15
25 N/A autoclave manufacture and repair
N/A
Rank Products Profile Top Local Executive
* on market * year founded * name
* in clinical * ownership * title
trial * phone
* in development
1 9 1980 Kevin W. Sharer
22 (1) public chairman, ceo, president
16 (1) (805) 447-1000
2 N/A 1971 Michael Ziering
N/A public ceo
N/A (310) 645-8200
3 187 2006 Dr. Patrick Soon-Shiong
3 public chairman, ceo, president
14 (310) 826-8505
4 246 1990 Robert Hayman
2 private ceo, president
5 (310) 845-8200
5 0 1991 Alfred Mann
1 public ceo
1 (661) 775-5300
6 N/A 1996 Jane Salik
N/A private ceo, president
N/A (310) 782-3569
7 10 1978 Judi Irving
0 public ceo, president
0 (818) 226-1968
8 N/A 1982 David Bailey
N/A public ceo, president
N/A (626) 303-7902
9 10 1979 Cesar Garcia
0 public ceo, president
6 (818) 709-1244
10 58 1990 L. Michael Cutrer
0 public ceo, president
2 (818) 734-8600
11 N/A 1982 Earl Yager
N/A public ceo, president
N/A (818) 882-0883
12 30 1981 Jeff Hynes
0 private president
0 (626) 331-0861
13 N/A 1990 Dr. Robert Felton
N/A private ceo, president
N/A (877) 686-6832
14 1,000 1969 Johnson Wong
N/A private president
N/A (323) 583-1331
15 0 1997 Bassil Dahiyat
0 private ceo, president
3 (626) 305-5900
16 40 1974 Robert W. Ban
N/A private chairman, president
N/A (310) 536-0006
17 3 2001 Dr. Bradley E. Patt
0 private ceo, president
N/A (818) 709-2468
18 3 1999 Thomas T. Hacking
0 private chairman, ceo
0 (310) 643-6900
19 10 2005 Fred Held
12 private ceo, president
12 (310) 890-3244
20 10 1991 Dr. Wen G. Tsang
N/A private sr. v.p., research and
N/A development
(310) 264-7768
21 N/A 1996 Dr. David Rozzell
N/A private ceo, president
N/A (626) 585-9797
22 2 1999 Steve Alexander
0 private president, coo
2 (562) 498-1776
23 0 1985 Steven A. Kriegsman
2 public ceo, president
5 (310) 826-5648
24 10 1992 Steven Wheeler
N/A private president
N/A (310) 324-6576
25 N/A 1971 Glenn Caster
0 private ceo
0 (562) 046-3505
N/A--Not Applicable
(1) As of January 26, 2006.
Note: Information for this list was provided by the companies
themselves. Companies are ranked by the total number of employees and
the number of L.A. County employees, respectively.
To the best of our knowledge, this information is accurate as of press
time. While every effort is made to ensure the accuracy and
thoroughness of the list, omissions and typographical errors sometimes
occur. Please send corrections or additions on company letterhead to
the Research Department, Los Angeles Business Journal, 5700 Wilshire
Blvd., Suite 170, Los Angeles 90036. [c]2006 Los Angeles Business
Journal. This list may not be reprinted in whole or in part without
prior written permission from the editor. Reprints are available from
Wright's Reprints, (877) 652-5295.
Researched by David Nusbaum
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