Biomarkers of Arsenic Effects on Gene Expression in Human Skin.1843399008 Biomarkers of arsenic arsenic (är`sənĭk), a semimetallic chemical element; symbol As; at. no. 33; at. wt. 74.9216; m.p. 817°C; (at 28 atmospheres pressure); sublimation point 613°C;; sp. gr. (stable form) 5.73; valence −3, 0, +3, or +5. effects on gene expression in human skin. Ed. by Jerome Nriagu and Luda Bernstam. American Water Works Assn. 2004 106 pages $205.00 Paperback RA1231 Elevated levels of arsenic in US water supplies occur in many areas, and skin cancer has been linked to arsenic in drinking water drinking water supply of water available to animals for drinking supplied via nipples, in troughs, dams, ponds and larger natural water sources; an insufficient supply leads to dehydration; it can be the source of infection, e.g. leptospirosis, salmonellosis, or of poisoning, e.g. . This report of an exploratory study funded by the Awwa Research Foundation examines the effects of arsenic exposure on lab-grown human skin. The study found that low-level exposures for periods as short as one hour produced skin damage at cellular and molecular levels. Further employment of this novel approach is recommended to protect against arsenic toxicity toxicity /tox·ic·i·ty/ (tok-sis´i-te) the quality of being poisonous, especially the degree of virulence of a toxic microbe or of a poison. , based on insights gained into inhibition of the signal transduction Signal transduction The transmission of molecular signals from a cell's exterior to its interior. Molecular signals are transmitted between cells by the secretion of hormones and other chemical factors, which are then picked up by different cells. pathway pathway /path·way/ (path´wa) 1. a course usually followed. 2. the nerve structures through which an impulse passes between groups of nerve cells or between the central nervous system and an organ or muscle. triggered by stress. The editors are with the U. of Michigan's department of environmental and industrial health. ([c] 2005 Book News, Inc., Portland, OR) |
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