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Bioengineered skin interacts like living tissue with host.



Bioengineered skin grafts seem to interact with patients' own skin just as other living tissue would, according to a study by researchers at Brown University School of Medicine in Providence, RI and Boston University School of Medicine Boston University School of Medicine (BUSM) is one of the graduate schools of Boston University. It is an American medical school located in the South End neighborhood of Boston, Massachusetts.  in MA.

The investigators performed histologic examinations of wound sites 2 to 6 weeks after placement of Graftskin (Organogenesis, Canton, MA), a bioengineered skin composed of bovine collagen, viable dermal fibroblasts, and viable keratinocytes Keratinocytes
Cells found in the epidermis. The keratinocytes at the outer surface of the epidermis are dead and form a tough protective layer. The cells underneath divide to replenish the supply.
. They point to the presence of mucin mucin: see glycoprotein.  in both the patient's dermis dermis: see skin.  and in the dermal material from the Graftskin as evidence of interaction and stimulation of both patient and bioengineered dermis to produce ground substance [the intercellular material of connective tissue]. (Journal of the Academy of Dermatology 2002;46:524-530.)
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Comment:Bioengineered skin interacts like living tissue with host.(Brief Article)
Publication:Transplant News
Article Type:Brief Article
Geographic Code:1USA
Date:Jun 14, 2002
Words:122
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