BioTrove Launches Next-Generation Mass Spectrometry System, Enables Accelerated Drug Discovery Research.Enhanced RapidFire[TM] System Advances R&D with Walk-Away Automation Development Funded Confidentially by Top-10 Pharmaceutical Company WOBURN, Mass. -- BioTrove, Inc. today announced launch of its second-generation RapidFire Mass Spectrometry mass spectrometry or mass spectroscopy Analytic technique by which chemical substances are identified by sorting gaseous ions by mass using electric and magnetic fields. system. Capable of fully-automated, unattended operation for up to eight hours, during which a total of ten 384-well microtiter plates A Microtiter plate or microplate is a flat plate with multiple "wells" used as small test tubes. The microplate has become a standard tool in analytical research and clinical diagnostic testing laboratories. can be analyzed, the enhanced system was developed in collaboration with a major U.S. pharmaceutical company that confidentially funded the project in order to receive accelerated delivery of the first instrument. "Research is a 24-7 effort. Our customers expressed urgent need for walk-away automation and the ability to run the system for extended periods without staff support in order to improve research speed and efficiency," said Can Ozbal, Ph.D., General Manager of RapidFire Products. "The new RapidFire system makes that possible, thanks to close collaboration with our customers-something we've embraced since installing the first RapidFire Mass Spectrometry system three years ago. This next-generation instrument results from our tireless commitment to supporting customers' work," he added. Unlike other high-throughput mass spectrometry systems, the newly-released RapidFire system is fully automated to facilitate walk-away analysis. The next-generation instrument also incorporates new hardware and software features to streamline non-primary screening applications-including kinetic experiments, supporting structure-activity relationship Structure-activity relationship is the traditional Practices of Medicinal chemistry which try to modify the effect or the potency of Bioactive chemical compound by modifying its Chemical structure. studies through the determination of IC50 values and mechanism of inhibition studies, along with in vitro in vitro /in vi·tro/ (in ve´tro) [L.] within a glass; observable in a test tube; in an artificial environment. in vi·tro adj. In an artificial environment outside a living organism. ADME ADME Absorption, Distribution, Metabolism, and Excretion ADME Association of Destination Management Executives ADME Active Duty Medical Extension experiments-in which data quality is of the utmost importance. A number of improvements to minimize sample-to-sample carryover and to maximize sensitivity and accuracy have also been incorporated into the new RapidFire system. "Eight of the top 12 U.S. pharmaceutical companies now use RapidFire to advance drug discovery, lead optimization and pipeline development efforts, and our dialogue with these industry leaders enables us to hear first-hand which features and applications are important to big pharma," said Al Luderer, Ph.D., president and CEO (1) (Chief Executive Officer) The highest individual in command of an organization. Typically the president of the company, the CEO reports to the Chairman of the Board. of BioTrove. "The next-generation RapidFire system shows the power of collaboration with outcomes-oriented preclinical laboratories, and resulted in the instrument they desired." For more information on the next generation RapidFire Mass Spectrometry system hardware or applications, please visit www.biotrove.com/RF2. About BioTrove, Inc. BioTrove, Inc. offers two innovative technology platforms: RapidFire[TM], which enables the acceleration of drug discovery and pipeline decisions, and OpenArray[TM], which advances genomic research in a wide range of life science fields, including agriculture, disease research, bio-defense, and public health. With more than half of the world's ten largest pharmaceutical companies as clients, and partnerships with prestigious research and public health centers around the world, BioTrove's products and services ensure that an industry committed to accuracy and speed can meet business goals. RapidFire[TM] Mass Spectrometry (RFMS RFMS Recipient Financial Management System (Pell Grants) RFMS Regional Financial Management System RFMS Reading-Fleming Middle School RFMS Rotorcraft Flight Manual Supplement (US FAA) ) uses an innovative microfluidic technology to facilitate analysis at faster than 10 seconds per sample, eliminating the bottleneck created by traditional mass spectrometry throughput. RFMS is routinely used in many applications, including the high-throughput screening High-throughput screening (HTS), is a method for scientific experimentation especially used in drug discovery and relevant to the fields of biology and chemistry. Purpose and method of previously intractable drug targets, cytochrome cytochrome (sī`təkrōm'), protein containing heme (see coenzyme) that participates in the phase of biochemical respiration called oxidative phosphorylation. P450 inhibition and other ADME assays and directed evolution Directed evolution is a method used in protein engineering to harness the power of Darwinian selection to evolve proteins or RNA with desirable properties not found in nature. studies. The OpenArray[TM] Platform enables genomics researchers to generate SNP SNP Scottish National Party Noun 1. SNP - (genetics) genetic variation in a DNA sequence that occurs when a single nucleotide in a genome is altered; SNPs are usually considered to be point mutations that have been evolutionarily and real time qPCR data in the hundreds of thousands of data points per day, significantly increasing the number of samples analyzed while significantly decreasing the time and cost required. The flexible format and nanoliter scale of the OpenArray[TM] system allows for easy adjustment of sample and assay numbers, achieving economical, high-throughput genomics. For more information, please visit www.biotrove.com. |
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