Bio3 Research and Creabilis Therapeutics Sign Research Agreements with Cephalon, Inc. Research Will Focus on Potential New Treatments for Psoriasis and Restenosis.COLLERETTO GIACOSA (Turin), Italy, and MILAN Milan, prince and king of Serbia Milan (Milan Obrenović) (mĭl`än ōbrĕ`nəvĭch), 1854–1901, prince (1868–82) and king (1882–89) of Serbia; grandnephew of Miloš Obrenović. , Italy -- Bio3 Research S.r.l., and Creabilis Therapeutics S.p.A. announced agreements with Cephalon Ceph´a`lon n. 1. (Zool.) The head. , Inc. to evaluate the research compound K252a for its potential to topically treat psoriasis psoriasis (sôrī`əsĭs), occasionally acute but usually chronic and recurrent inflammation of the skin. The exact cause is unknown, but the disease appears to be an inherited, possibly autoimmune disorder that causes the and for potential use in the prevention and treatment of restenosis. Creabilis Therapeutics owns patent applications covering K252a-based products for the treatment of psoriasis. Bio3 Research and Creabilis Therapeutics co-own a patent application covering the use of K252a compound to prevent and treat restenosis and other cardiovascular disorders. Cephalon has proprietary rights in certain production processes for the compound. Also, with respect to the prevention and treatment of restenosis, Bio3 Research retains the right to collaborate with third parties in combining K252a with drugeluting stents. Other terms of the agreements were not disclosed. Under the agreement, Cephalon has an exclusive option to develop and commercialize K252a-based products that may result from research performed by Creabilis Therapeutics and Bio3 Research. "This agreement with Cephalon is a great opportunity for Creabilis Therapeutics because it enables us to accelerate the development process of this promising compound," said Dr. Silvano Fumero, the company's CEO (1) (Chief Executive Officer) The highest individual in command of an organization. Typically the president of the company, the CEO reports to the Chairman of the Board. . "We expect to file the INDs by the end of 2006." Francesco Paolo Pilato, President and CEO of Bio3 Research, said, "We are delighted to have entered into this agreement with Cephalon, and we believe it is a great opportunity for our company to accelerate the ongoing development process at Creabilis Therapeutics. This research is part of Bio3's strong IP position in the field of HMGB1-related cardiovascular disorders." About Creabilis Therapeutics S.p.A. Creabilis Therapeutics S.p.A. is a privately owned drug-discovery and development company, founded in 2003 and located in the Bioindustry Park of Canavese, near Turin. The company's activity focuses mainly on DNA-binding proteins DNA-binding proteins are proteins that comprise any of many DNA-binding domains and thus have a specific or general affinity to DNA. DNA-binding proteins include transcription factors which modulate the process of transcription, nucleases which cleave DNA molecules, and , such as HMGB1, as pharmacological Pharmacological Referring to therapy that relies on drugs. Mentioned in: Pain Management pharmacological, pharmacologic pertaining to pharmacology. targets for novel classes of inhibitors/antagonists to be developed as therapeutics. This portfolio is complemented by selected projects in related biochemical or clinical areas. Additional information on Creabilis Therapeutics can be obtained from www.creabilistherapeutics.com or by e-mail: info@creabilistherapeutics.com About Bio3 Research s.r.l. Bio3 Research s.r.l., an Italian company founded in 2001, has headquarters in Milan and an office at the Bioindustry Park of Canavese (Turin). Bio3 Research works with research institutions, individual scientists and early-stage companies to identify, protect and exploit commercially promising intellectual property in the life sciences. Such assistance may include pre-clinical development Pre-clinical development is a stage in the development of a new drug that begins before clinical trials (testing in humans) can begin, and during which important safety and pharmacology data is collected. and negotiation of strategic industrial partnerships. Bio3 Research's activity focuses mainly on the field of HMBG1-related cardiovascular disorders and use of HMGB1 and its fragments in connective connective - An operator used in logic to combine two logical formulas. See first order logic. tissue regeneration. Other fields of interest include skin and renal diseases Renal disease Kidney disease. Mentioned in: Glycogen Storage Diseases hypertension High blood pressure Cardiovascular disease An abnormal ↑ systemic arterial pressure, corresponding to a systolic BP of > 160 mm Hg . Additional information on Bio3 Research can be obtained from www.bio3research.com or by e-mail: info@bio3research.com |
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