Bio-Matrix Issues Shareholder Update.

SAN DIEGO -- Bio-Matrix Scientific Group, Inc. (Pink Sheets:BMXP), a biotechnology company focused on stem cell cryogenics and disposable stem cell / tissue transfer instruments, (http://www.bmxgonline.com), reported today that it has received a number of inquiries as to the status of its instrumentation, stem cell banking facilities and laboratories. In an effort to update shareholders, the Company issues the following state-of-the-company remarks:

Dear Fellow Shareholders:

The following information is an update on current projections and
developments:

Instruments:

Stem Cell and Tissue Management Instruments (Humans): Bio-Matrix'
medical devices have been completed and are in the beta testing stage
at this time. Testing consists of the following: Gamma Radiation
Sterilization Testing, Pull Testing for bonding, Equipment Validation
and Packing -- ISTA certified age & temperature testing. Once this is
completed Bio-Matrix anticipates production, sales, and marketing of
these Medical Devices will begin.

FDA: Bio-Matrix is in the GMP process (Good Manufacturing Practices).
To assist in the GMP documentation, Bio-Matrix has contracted with
Emergo Group, an FDA Consulting Group out of Clearwater, FL. The
Company believes the GMP process will be completed in mid-2006.
Bio-Matrix will be able to sell its medical devices starting in 2006
while this process is going on.

Veterinary Instrumentation for Regenerative Medicine in Animals: This
represents a completely new line of stem cell extraction devices
specifically for veterinary regenerative medicine. The Company has
designed hubs and steel tip-styles specifically developed for animals.
The Company is currently Beta testing these instruments.

While it may not initially be apparent, the technology used in
veterinary instruments dovetails into the Beta testing of the human
instrumentation developed by the Company. This serves to advance
designs for future new applications of the Company's technology.

New Facilities:

a.) Cryogenic Labs
To date, two Cryogenic Labs have been completed. The first of eight
Cryogenic storage tanks has been installed and is under going testing.

b.) Class 10,000 Clean Rooms
Currently, several class 10,000 clean rooms are under construction and
should be completed by the end of February or early March 2006.

c.) Engineering Lab
The Company anticipates that its new engineering lab should be
completed by the end of January 2006. This facility will allow
Bio-Matrix to bring in house its medical device design and development
activities.

The management team of Bio-Matrix Scientific Group Inc. believes that
the Company is truly dynamic in its market niche. The management of
the Company invites shareholders to visit the facility to see for
themselves the progress that has been made in implementing and growing
the Company's business model. Shareholders wishing to see the
facilities and meet with management are invited to do so with
appropriate advanced notification of their intent.

This press release is available on the company's official online Investor Relations HUB at http://www.agoracom.com/IR/Bio-Matrix for investor questions, answers and monitored commentary. Alternatively, investors are able to e-mail all questions and correspondence to [e-mail] where they can also request addition to the investor e-mail list to receive all future press releases and updates in real time.

About Bio-Matrix Scientific Group Inc.:

Bio-Matrix Scientific Group Inc. is a development stage company in the business of medical devices and monitoring systems research, development and commercialization. Bio-Matrix Scientific Group Inc. is aligning itself with partners that offer key technologies in biomedical device development, tissue engineering, cell culturing, genome therapy and drug delivery systems. Other companies in the same industry as Bio-Matrix Scientific Group Inc. (Pink Sheets:BMXP) are Cord Blood America (OTCBB:CBAI), StemCells Inc. (NASDAQ:STEM) and Regeneration Technologies (OTCBB:RTIX).

More information will be available shortly on the Company's website: www.BMXGonline.com.

DISCLAIMER: This news release contains forward-looking statements. Forward-looking statements are inherently subject to risks and uncertainties, some of which cannot be predicted or quantified. Future events and actual results could differ materially from those set forth in, contemplated by, or underlying the forward-looking statements. The risks and uncertainties to which forward-looking statements are subject include, but are not limited to, the effect of government regulation, competition and other material risks.