Biacore and Bruker Daltonics Announce Strategic Collaboration in Functional Proteomics.

Business/Technology Editors & Health/Medical Writers

BIOWIRE2K

UPPSALA, Sweden and BILLERICA, Mass.--(BUSINESS WIRE)--Oct. 31, 2001

Joint Development and Co-Marketing of SPR-MS Technology Will

Accelerate Proteomic Studies, Leading to Accelerated Target ID for

Therapeutics Development

Biacore International AB (SSE and NASDAQ: BCOR) and Bruker Daltonics Inc. (NASDAQ: BDAL) today announced a new collaboration that aims to advance proteomics research dramatically by associating critical functional information with mass spectrometric identification and characterization of novel proteins critical to the disease process.

This collaboration draws upon Biacore's status as a global market leader in providing functional information on biomolecular binding interactions using its proprietary surface plasmon resonance (SPR) technology, and Bruker Daltonics' cutting-edge life-science systems based on mass spectrometry (MS). Together, the companies aim to commercialize the combined technique of SPR-MS in order to create an exciting comprehensive platform for functional proteomics studies. This will help pharmaceutical and biotech companies fast track targets for validation and enable more rapid development of therapeutic compounds.

Clive Seymour, Vice President and Head of Life Science Research Business Unit at Biacore, commented: "This collaboration demonstrates Biacore's commitment to increasing the level of information that our SPR technology can provide for proteomics research. We believe the proteomics market will be worth $5.6 billion by 2005(1). Furthermore, we expect this growth to be fueled by the distinct advantages presented by the combination of our technologies. By adding functional data from Biacore to the molecular identification and characterization data obtained from Bruker Daltonics' MS systems, we hope to initiate a radical new approach for functional proteomics studies."

Cited in over 2000 peer-reviewed publications, Biacore's SPR technology is already well recognized as a key tool for functional analyses including protein-protein interactions, ligand fishing and now SPR-MS. Using unique microfluidics and sensor chip-based systems, this technology has enormous application in proteomics studies, allowing proteins and their function to be studied in a label-free, near native environment. In addition, it can act as a micropurification and recovery system to provide samples for further studies, such as mass spectrometry.

Bruker Daltonics is a leading supplier of life-science systems offering the growing proteomics research community a wide choice of MS-based research tools. Increasing the information content and understanding of functional complexes through the addition of affinity and kinetic molecular interaction data promises to offer new insights for proteomic studies, advancing them beyond current mapping, identification and differential expression approaches.

Dr. Michael Schubert, European Director of R&D at Bruker Daltonics, said: "We are delighted to be working alongside Biacore to develop and commercialize the SPR-MS technique. By integrating the SPR-MS systems and the complementary information they generate, we aim to add the unique functional information obtained using Biacore's SPR technology to proteomics databases, allowing users to correlate functional information with the identification and characterization data obtained from mass spectrometry."

(1)Frost and Sullivan Proteomics Market Profiles Report. Report 6390-55.

Cautionary Statement

This press release contains certain forward-looking statements within the meaning of the United States Private Securities Litigation Reform Act of 1995, which, by their nature, involve risk and uncertainty because they relate to events and depend on circumstances that will occur in the future. There are a number of factors that could cause actual results and developments to differ materially from those expressed or implied by these forward-looking statements.

About Biacore

Biacore is a global market leader in Surface Plasmon Resonance (SPR) based technology with its own sales operations in the U.S., across Europe, in Japan, Australia and New Zealand. The technology is protected by a strong patent portfolio. Target groups consist primarily of medical and life science research laboratories and pharmaceutical and biotechnology companies all over the world. Biacore focuses on drug discovery as the prime area for future growth. The company currently has six systems on the market with its BIACORE(R)3000 system offering specific application in drug discovery processes upstream of high-throughput screening (HTS). A new high-performance system is currently under late-stage development and will focus on applications downstream of HTS. Based in Uppsala, Sweden, the company is listed on Stockholmsborsen and Nasdaq in the U.S. In 2000 the company had sales of SEK 438.8 million and an operating income of SEK 78.0 million.

Further information on Biacore can be found on the web:
www.biacore.com

Address and phone:      Biacore International AB
                        Rapsgatan 7, SE-754 50 Uppsala, SWEDEN
                        Phone: [phone] Fax: [phone]
                        e-mail: [e-mail]

About Bruker Daltonics

Bruker Daltonics is a leading provider of innovative life science tools based on mass spectrometry. Its substantial investment in research and development allows it to design, manufacture and market a broad array of products intended to meet the rapidly growing needs of a diverse customer base, including pharmaceutical companies, biotechnology companies, proteomics companies, molecular diagnostics companies, academic institutions and government agencies. Bruker Daltonics has diverse technology platforms that integrate automated sample preparation and clean-up, advanced front-end AnchorChip(TM) MALDI targets and API source technology with cutting-edge proprietary MALDI-TOF, MALDI-TOF/TOF, ESI-TOF, ESI-Q-q-TOF, ion trap and FTMS mass analyzers, as well as analysis and bioinformatics software. Bruker Daltonics is also a worldwide leader in supplying mass spectrometry-based systems for substance detection and pathogen identification in security, defence and anti-terrorism applications. Further information is available at: www.bdal.com