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Beware of adrenal insufficiency with atypicals.

NEW ORLEANS -- Recognizing the potential for atypical antipsychotics to cause adrenal insufficiency is important to ensure that this serious condition is managed appropriately, two experts said.

In one case, Dr. Violeta Tan and Dr. Natalie Rasgon described a 54-year-old man with a history of depression and posttraumatic stress disorder who was admitted to the hospital after complaining of malaise 9 days after a previous admission for a urinary tract infection that had been treated with ciprofloxacin.

At the time of the first admission, the patient was restarted on 225 mg/day of bupropion and 300 mg/day of quetiapine (Seroquel). He had discontinued these medications 6-8 months prior, said Dr. Tan and Dr. Rasgon, who presented the case in a poster session at the American Psychiatric Association's Institute of Psychiatric Services.

Symptoms at the time of the second admission included fatigue, warmth, chills, loose stools, mild headache, and reproducible chest wall pain. Laboratory findings showed that previously normal eosinophil levels were elevated (6.5%-8.3%), reported Dr. Tan and Dr. Rasgon, both of Stanford (Calif.) University.

A work-up for infection, malignancy, and rheumatologic conditions was negative, and primary adrenal insufficiency was ruled out based on the findings of a cosyntropin stimulation test. However, adrenocorticotropic hormone (ACTH) levels (which were less than 5 pg/mL) indicated secondary or tertiary adrenal insufficiency, and a review of the patient's medications alerted the authors to the possibility of quetiapine-associated ACTH and cortisol reductions.

Atypical antipsychotics such as quetiapine have been shown to reduce cortisol levels--often in association with improved psychopathology. Thus, although the cortisol-lowering effects of such drugs may ameliorate negative symptomatology, the reduction "may be to a detrimental extent," they wrote.

However, adrenal insufficiency caused by such agents has not been specifically studied, and although it might seem appropriate to discontinue the "offending agent," the risks of discontinuing antipsychotics should be weighed against the benefits of preventing adrenal insufficiency sequelae, they added.

In the current case, the patient's condition improved dramatically after quetiapine--a standard treatment for adrenal insufficiency--was administered at 20 mg every morning and at 10 mg at bedtime.

Atypical antipsychotics can cause adrenal insufficiency, which presents ambiguously, and awareness of this problem can be key in preventing false diagnoses, the investigators concluded.


Southeast Bureau

RELATED ARTICLE: Four Areas Are Key to Diagnosis

Dr. Tan and Dr. Rasgon say determining whether a patient has developed adrenal insufficiency requires an investigation into four areas:

* Symptoms. Look for fatigue, abdominal distress, anorexia, nausea, vomiting, myalgia or arthralgia, postural dizziness, salt craving, headache, impaired memory, and depression.

* Physical findings. Some factors to look out for are increased pigmentation, postural hypotension, tachycardia, fever, decreased body hair, vitiligo, and cold intolerance.

* Laboratory findings. Red flags include hyponatremia, hyperkalemia, hypoglycemia, eosinophilia, and elevated thyroid stimulating hormone.

* Clinical problems. Watch for hemodynamic instability, ongoing inflammation, multiple-organ dysfunction, and hypoglycemia.
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Title Annotation:Adult Psychiatry
Author:Worcester, Sharon
Publication:Clinical Psychiatry News
Date:Dec 1, 2007
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