Beryllium-Induced Disease.

The goal of this proposed research initiative is to encourage and support studies that will advance our understanding of the mechanisms of chronic beryllium disease (CBD). The participating institutes and agencies are interested in supporting research in (but not limited to) the following areas: 1) the genetic basis of beryllium sensitivity and development of CBD, 2) inflammation and granuloma formation, 3) development of in vitro and in vivo models of beryllium sensitivity, 4) biomarkers of beryllium sensitivity and progression of CBD, and 5) methods of prevention.

Applicants must use Application Form PHS 398, which has annual due dates of February 1, June 1, and October 1. Additional information is available on the Internet at http://grants.nih.gov/grants/guide/ pa-files/PA-99-075.html.

Contact: George Malindzak, Organs and Systems Toxicology Branch, NIEHS, PO Box 12233, MD EC-23, Research Triangle Park, NC 27709 USA, 919-541-3289, fax: [phone], e-mail: [e-mail]; Robert Musson, Division of Lung Biology and Disease Program, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 10108, MSC 7952, Bethesda, MD 20892-7952 USA, 301-435-0222, fax: [phone], e-mail: [e-mail]; Roy M. Fleming, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Building 1, Room 3053, MS-D30, Atlanta, GA 30333 USA, 404-639-3343, fax: [phone], e-mail: rmf2@ cdc.gov; or Paul J. Seligman, Deputy Assistant Secretary, Office of Health Studies, Department of Energy, 19901 Germantown Road, Germantown, MD 20874 USA, 301-903-5926, fax: [phone], e-mail: [e-mail]. Reference: PA No. PA-99-075