Printer Friendly

Battle of the T-cells.

Last year, experiments suggested that two types of T-lymphocytes -- CD4 and CD 8 -- spar with each other in diabetes-prone mice. Researchers concluded that CD8 cells may play a protective role in these mice by suppressing the CD4 cells, which attack pancreatic islet cells (SN:3/31/90, p.198).

Now, another T-cell has entered the fray. Charles Janeway Jr. and his colleagues at Yale University propose that "autoreactive" T-lymphocytes are the real protecting influence and that CD4 and CD8 cells combine forces for a destructive effect.

The Yale group injected irradiated mice, which normally do not develop diabetes, with cloned CD4 and CD8 cells. The majority of the mice receiving a mix of the two types became diabetic, Janeway reports, while most of those receiving either cell type alone have so far avoided the disease.

In another experiment, the researchers injected cloned autoreactive T-cells into prediabetic mice. So far, only a few have developed the disease. "A single injection greatly retards the onset of diabetes," concludes Janeway. He theorizes that the autoreactive T-cells help regulate diabetes by suppressing the production of islet-attacking T-cells and by protecting the islets themselves.
COPYRIGHT 1991 Science Service, Inc.
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 1991, Gale Group. All rights reserved. Gale Group is a Thomson Corporation Company.

Article Details
Printer friendly Cite/link Email Feedback
Title Annotation:role of CD4, CD8, and T-lymphocytes in diabetes
Author:Travis, John
Publication:Science News
Date:Jul 6, 1991
Previous Article:Diabetic distinction debated.
Next Article:Epilepsy and pregnancy: a drug dilemma.

Related Articles
Mouse study suggests diabetes prevention.
Tuberculosis vaccine: diabetes defense?
HIV also kills developing white blood cells.
New role for immune cells in diabetes.
Body's proteins suppress AIDS virus.
AIDS virus may feast on an unexpected meal.
Spontaneous remission of B-cell chronic lymphocytic leukemia associated with T lymphocytic hyperplasia in bone marrow. (Case Reports).
Immune protein may stall HIV. (Immunology).
Alteration of pulmonary immunity to Listeria monocytogenes by diesel exhaust particles (DEPs). II. Effects of DEPs on T-cell-mediated immune...
Absolute CD4 and CD8 counts and CD4-to-CD8 ratios in eight patients with indolent B-cell chronic lymphocytic leukemia.

Terms of use | Copyright © 2016 Farlex, Inc. | Feedback | For webmasters