BRUKER DALTONICS UNVEILS NEW PROTEOMICS PRODUCTS.Bruker Daltonics Bruker Daltonics is a global scientific instrument manufacturer. The company is a part of Bruker Biosciences Corporation (Nasdaq:BRKR) and specializes in mass spectrometry. The Bruker Daltonics headquarters are in Billerica, MA - USA and Bremen, Germany. Inc. (NASDAQ NASDAQ in full National Association of Securities Dealers Automated Quotations U.S. market for over-the-counter securities. Established in 1971 by the National Association of Securities Dealers (NASD), NASDAQ is an automated quotation system that reports on : BDAL BDAL Battle Doll Angelic Layer (game) ) has introduced several major products for proteomics. "We continue to develop and commercialize innovative life-science products at a rapid rate," commented Dr. Frank H. Laukien, president and CEO (1) (Chief Executive Officer) The highest individual in command of an organization. Typically the president of the company, the CEO reports to the Chairman of the Board. . "I am excited about our new proteomics products introduced at ASMS ASMS American Society for Mass Spectrometry ASMS Association of Salaried Medical Specialists ASMS Advanced Satellite Mobile Systems ASMS Alabama School of Mathematics and Science ASMS American Society for Mohs Surgery ASMS Arkansas School for Math and Science , and believe that they will be very well accepted by customers due to their significant advantages in terms of performance and productivity." NEW Q-Q-TOF SYSTEM Bruker Daltonics has introduced BioTOF(R)-Q, a novel ultra-high performance electrospray ionization Electrospray ionization (ESI) is a technique used in mass spectrometry to produce ions. It is especially useful in producing ions from macromolecules because it overcomes the propensity of these molecules to fragment when ionized. (ESI (Edge Side Includes) A markup language for Web pages that enables elements of a Web page to be dynamically assembled in servers distributed throughout the Internet. ) mass-selective quadrupole A quadrupole is one of a sequence of configurations of electric charge or gravitational mass that can exist in ideal form, but it is usually just part of a multipole expansion of a more complex structure reflecting various orders of complexity. / collision quadrupole / time-of-flight analyzer (Q-q-TOF) mass spectrometer. -- The BioTOF-Q adds tandem mass spectrometry Tandem mass spectrometry, also known as MS/MS, involves multiple steps of mass spectrometry selection, with some form of fragmentation occurring in between the stages. (MS/MS MS/MS Tandem Mass Spectroscopy MS/MS Multistage Mass Spectrometry ) capabilities to our BioTOF II high-resolution ESI-TOF system. -- Tandem mass spectrometry using a Q-q-TOF geometry permits the sensitive and highly accurate determination of molecular fragments in proteomics identification, de novo [Latin, Anew.] A second time; afresh. A trial or a hearing that is ordered by an appellate court that has reviewed the record of a hearing in a lower court and sent the matter back to the original court for a new trial, as if it had not been previously heard nor decided. peptide sequencing, complex mixture analysis and other life-science applications. -- The new BioTOF-Q system is unique due to its revolutionary, patented COMPASS(TM) method for significantly improved mass resolution greater than 20,000, and better mass accuracy than other Q-q-TOF systems. NEXT-GENERATION RESEARCH ION TRAP ion trap n. A device, such as a magnet, used to prevent ions in an electron beam from striking other apparatus. ion trap SYSTEM At the same time, Bruker Daltonics has announced its next-generation research-grade esquire3000 plus(TM) electrospray ionization (ESI) ion trap. The esquire3000 plus, developed in collaboration with Agilent Technology, features a new ion transfer mechanism for higher ion flux and significantly increased sensitivity. -- The esquire3000 plus offers the highest performance for the requirements of drug discovery and LC/MSn researchers. Particularly for proteomics applications, the overall sensitivity is improved by one order of magnitude A change in quantity or volume as measured by the decimal point. For example, from tens to hundreds is one order of magnitude. Tens to thousands is two orders of magnitude; tens to millions is three orders of magnitude, etc. . -- The esquire3000 plus provides new and superior data processing data processing or information processing, operations (e.g., handling, merging, sorting, and computing) performed upon data in accordance with strictly defined procedures, such as recording and summarizing the financial transactions of a capabilities like PepMassCreator(TM), or the innovative SmartSuite(TM) for an intuitive workflow. -- The esquire3000 plus continues to offer the highest standard mass range up to m/z = 3,000 without using lower-sensitivity "extended mass range" switching. It also provides the best combination of resolution and scan speed available. Both features are of significant importance in high-throughput proteomics. NEW MODULAR SUITE OF PROTEOMICS TOOLS In order to provide a comprehensive proteomics solution, Bruker Daltonics has introduced its innovative Proteineer(TM) suite of consumables, robotics, mass spectrometry mass spectrometry or mass spectroscopy Analytic technique by which chemical substances are identified by sorting gaseous ions by mass using electric and magnetic fields. systems and bioinformatics modules for proteomics. The Proteineer suite offers the unique combination of the two most powerful high-throughput proteomics methods of mass spectrometry for the protein identification funnel paradigm that is now widely accepted in proteomics facilities. Therefore, in addition to front-end sample preparation automation tools, consumables and robotics, the unique Proteineer concept offers the integrated use and adaptive intelligent acquisitions strategies for efficient protein identification by the following: -- their leading ultra-high throughput MALDI-TOF MALDI-TOF Matrix Assisted Laser Desorption Ionization - Time of Flight systems as a first protein identification assay, -- an optional MALDI-TOF MS/MS 2nd assay for a quantum jump in protein identification productivity, as well as -- robust high-performance ion trap ESI/MSn as a third assay for protein identification, determination of post-translational modifications, to obtain increased sequence coverage, for the identification of proteins in mixtures, and for protein quantitation. Bruker Daltonics believes that this is the most suitable and productive combination of tools for high-throughput proteomics by mass spectrometry. NEW GEL ANALYSIS SYSTEM AND SPOT CUTTER An important new module of our Proteineer suite of proteomics tools is the newly-introduced mac(TM) (MALDI MALDI Matrix-Assisted Laser Desorption/Ionization Automated Gel Cutter), which integrates imaging of the gel, visual analysis, spot selection, and cutting of spots out of 2D gels used for protein separations. The mac automates and simplifies many of the otherwise tedious tasks in preparing samples prior to MALDI-TOF-MS or ESI-MS/MS analysis of proteins. -- mac is based on our successful map(TM) II MALDI AutoPrep system, and further extends the Bruker Daltonics proteomics sample preparation robotics offering. -- An advanced digital scanner is incorporated for gel imaging and visualization. -- mac control software utilizes EXCEL spreadsheets, incorporates a viewer to visualize the gel image, and allows manual editing of the spot list to be excised. -- mac control is modular and also supports other commercial spot picking software for automatic and/or manual spot detection. NEW BIOINFORMATICS PRODUCT FOR COMPREHENSIVE PROTEOMICS DATA WAREHOUSING AND ANALYSIS As a fifth new product, Bruker Daltonics has announced ProteinScape(TM), a bioinformatics software package for comprehensive proteomics data warehousing and analysis, developed in collaboration with leading pharmaceutical and proteomics research companies. -- ProteinScape provides a web-based client-server platform for storing, organizing and analyzing data generated in the entire workflow of proteomics. It operates with industry standard relational database systems. -- ProteinScape automatically collects data including gel objects from gel imaging software. It supports a modular and flexible approach to bioinformatics queries by supporting different search engines in the protein identification step. -- ProteinScape's integration of Bruker Daltonics` program BioTools(TM) provides a clear and comprehensive view into the protein identification process. -- ProteinScape allows auto-annotation of protein assignments in gel images, direct linkage of gel-spots to acquired spectra and other related database entries for rapid navigation and viewing the results of the proteomics workflow. -- Via direct links to public annotated protein databases ProteinScape gives immediate access to additional relevant information. ABOUT BRUKER DALTONICS Bruker Daltonics is a leading developer and provider of innovative life science tools based on mass spectrometry. Its substantial investment in research and development allows it to design, manufacture and market a broad array of products intended to meet the rapidly growing needs of a diverse customer base, including pharmaceutical companies, biotechnology companies, proteomics companies, molecular diagnostics companies, academic institutions and government agencies. Bruker Daltonics has diverse technology platforms which integrate automated sample preparation and clean-up, advanced front-end AnchorChip MALDI targets and API source technology with cutting-edge proprietary MALDI-TOF, ESI-TOF, ion trap and FTMS See Fusion FTMS. mass analyzers, as well as analysis and bioinformatics software. Bruker Daltonics is also a worldwide leader in supplying mass spectrometry-based systems for substance detection and pathogen identification in security and defense applications. For more information, call (978)663-3660, ext. 1339 or visit http://www.daltonics.bruker.com |
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