BIOSIGNAL/IER REPORT 100% ANTI-BACTERIAL EFFICACY OF LENSES.Biosignal (ASX ASX See: Australian Stock Exchange :BOS)and the Institute for Eye Research Ltd (IER IER Institut d'Economie Rurale IER Institute for Economic Research (Ljubljana, Slovenia) IER Institute for Employment Research IER Ion-Exchange Resin (building material) IER Initial Environmental Review ) report that interim results from recent in vitro in vitro /in vi·tro/ (in ve´tro) [L.] within a glass; observable in a test tube; in an artificial environment. in vi·tro adj. In an artificial environment outside a living organism. trials of contact lenses with permanently attached furanones have generated striking results of up to 100% anti-bacterial efficacy. The critical milestone prior to entering human trials with contact lenses is to demonstrate that contact lenses with permanently attached furanones are likely to be anti-bacterial and safe. On the 24th of May Biosignal reported that furanone-soaked lenses prevent bacterial attachment by up to 70 percent. For the first time, it has now been shown that these results can be further improved when Biosignal's furanones are permanently attached to contact lenses. "This outcome is extremely attractive to the competitive contact lens contact lens, thin plastic lens worn between the eye and eyelid that may be used instead of eyeglasses. Actors, models, and others wear them for appearance, and athletes use them for safety and convenience. market, which has a preference for a permanently attached active. This method is more likely to provide longer life anti-bacterial efficacy with a shortened product registration process," said Michael Oredsson, CEO (1) (Chief Executive Officer) The highest individual in command of an organization. Typically the president of the company, the CEO reports to the Chairman of the Board. and managing director of Biosignal. The two key pathogens in bacterial eye infections are Pseudomonas aeruginosa and Staphylococcus aureus and specific results in 24 hour trials show up to 85 percent efficacy vs. control against P aeruginosa and up to 100 percent efficacy vs. control against S aureus The aureus (pl. aurei) was a gold coin of ancient Rome valued at 25 silver denarii. The aureus was regularly issued from the 1st century BC to the beginning of the 4th century AD, when it was replaced by the solidus. . In addition, Biosignal has conducted separate trials on Pseudomonas aeruginosa over seven days with furanones permanently attached to glass slides. These trials show that the permanent furanone coating retains an anti-bacterial efficacy rate of over 90 percent vs. control after a week. This is a very important finding since the rapidly growing extended wear contact lenses is a particularly important target market. "We are very encouraged by these interim results from the ongoing trials" said Prof Mark Willcox, a senior consultant to the IER. "IER and Biosignal are currently testing a range of furanones and attachment strategies in vitro and expect to enter our first small human trial in the first half of 2005". The results on contact lenses and glass slides are also relevant to a broad range of other types of products such as catheters and orthopaedic devices where bacterial contamination is currently causing problems and where permanently attached furanones are a potential solution About Biosignal and furanone technology Biosignal listed on the ASX in April 2004 to commercialize a novel anti-bacterial technology. The first applications are reducing risks of infection from contact lenses and treating aquaculture aquaculture, the raising and harvesting of fresh- and saltwater plants and animals. The most economically important form of aquaculture is fish farming, an industry that accounts for an ever increasing share of world fisheries production. equipment as an effective and environmentally friendly anti-fouling. Furanones are based on a discovery that the eastern Australian seaweed Delisea pulchra produces natural furanones that disable bacteria's ability to colonise Verb 1. colonise - settle as a colony; of countries in the developing world; "Europeans colonized Africa in the 17th century" colonize annex - take (territory) as if by conquest; "Hitler annexed Lithuania" . The fundamental problem with existing anti-bacterials, including antibiotics, is their tendency to generate bacterial resistance. Bacteria rapidly produce resistant strains when faced with strong selective pressure by killing agents or growth-inhibitory agents. Furanones lull bacteria to inaction and appear to avoid the problem of bacterial resistance. Biosignal produces synthetic furanones effective on inanimate surfaces such as pipes, ship hulls, membranes and medical devices; and animate surfaces such as lungs, skin and teeth. About the Institute for Eye Research: The Institute for Eye Research is one of the elite Medical Research Institute's in Australia. Located in New South Wales New South Wales, state (1991 pop. 5,164,549), 309,443 sq mi (801,457 sq km), SE Australia. It is bounded on the E by the Pacific Ocean. Sydney is the capital. The other principal urban centers are Newcastle, Wagga Wagga, Lismore, Wollongong, and Broken Hill. , the Institute focuses exclusively on excellence in eye and vision research through investment in people, systems and innovation. The Institute makes significant contributions to national and international eyecare research, education and business development and is involved in a wide range of vision projects. These are centred on four key areas: * Management, prevention or cure of refractive errors * Management, prevention or cure of infection and inflammation of the cornea cornea: see eye. * Vision and eyecare education * Public health support through ICEE ICEE International Conference on Engineering Education ICEE Indiana Center for Economic Education (Purdue University) ICEE International Centre for Eye Education (Sydney, NSW, Australia) Giving Sight For more information, visit http://www.biosignal.com.au. |
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