BIORAL DELIVERY IMPROVES EFFICACY/REDUCES ASPIRIN SIDE EFFECTS.

BioDelivery Sciences International, Inc. (NASDAQ:BDSI), Newark, N.J., has announced that results of animal studies show that the patented cochleate based delivery system Bioral(TM), used with aspirin, improves efficacy at significantly lower dosage and substantially reduces gastrointestinal side effects.

The findings were presented at the "Inflammatory Processes in Drug Delivery" meeting in Philadelphia, PA. The Bioral(TM) Pharmaceutical Delivery System is a delivery system based on cochleates, which are calcium-phospholipid structures composed of naturally occurring materials that "wrap" around the drug being introduced into the body. The company has tested cochleates as a delivery system for other drugs, as well as micronutrients, but this is the first study which demonstrates the positive effects of the Bioral(TM) system with aspirin.

Sara Krause-Elsmore, PhD, a research scientist at BDSI who leads the Bioral Non-Steroidal Anti-Inflammatory Drug (NSAID) Cochleate Program, stated; "Taking anti-inflammatories, such as aspirin, for extended periods of time to combat chronic inflammation leads to serious problems in the digestive tract, like bleeding and ulcers. This data shows that cochleates greatly reduce GI side effects in animal models and increase efficacy of aspirin at lower doses."

The Bioral(TM) Pharmaceutical Delivery System uses cochleates, made of naturally occurring material, to surround the aspirin molecules. The cochleate crystalline structure protects the stomach lining and delivers the aspirin more efficiently to the inflamed cells. "Because cochleates protect the GI tract from the aspirin molecules, side effects are much less than with regular aspirin. Bioral(TM) does not change the molecule itself, and therefore the ability of the medication to decrease inflammation remains," said Dr. Krause-Elsmore.

About Bioral(TM) Pharmaceutical Delivery System

For additional information regarding BioDelivery's patented, Bioral(TM) Pharmaceutical Delivery System, visit our website at http://www.biodeliverysciences.com.

BioDelivery Sciences International, Inc. is a biotechnology company that is developing and seeking to commercialize a patented delivery technology designed for a potentially broad base of pharmaceuticals, vaccines, over-the counter drugs, and nutraceuticals and, through its subsidiary, Bioral Nutrient Delivery, LLC, micronutrients in processed foods and beverages.

For more information, call 973/972-0015 or visit http://www.biodeliverysciences.com.