BIOLOGISTS USE DATABASES TO FILTER GENOMIC INFORMATION.Compugen Ltd. (Nasdaq: CGEN CGEN Convective Sigmet Generation ), has launched Gencarta, a comprehensive platform providing access to Compugen's proprietary annotated genome, transcriptome The transcriptome is the set of all messenger RNA (mRNA) molecules, or "transcripts", produced in one or a population of cells. The term can be applied to the total set of transcripts in a given organism, or to the specific subset of transcripts present in a particular cell type. and proteome pro·te·ome n. The complete set of proteins that are produced by the genes of an organism. proteome the entire complement of proteins produced by a cell. databases. Biologists and other life science researchers are able to explore these annotated databases and focus in on genes of interest, helping them filter the mass of genomic and expressed information and better understand complex biological processes. GencartaTM will provide researchers with access to Compugen's proprietary LEADS transcriptome database. The periodic application of LEADS analysis and data mining tools to various public and non-public databases result in one comprehensive data source, which includes tens of thousands of predicted genes and splice variants, putative cSNPs and annotated genomic information. LEADS gene predictions Gene finding typically refers to the area of computational biology that is concerned with algorithmically identifying stretches of sequence, usually genomic DNA, that are biologically functional. have been tested in hundreds of cases and verified with a success rate of over 90% in Compugen's molecular biology molecular biology, scientific study of the molecular basis of life processes, including cellular respiration, excretion, and reproduction. The term molecular biology was coined in 1938 by Warren Weaver, then director of the natural sciences program at the Rockefeller laboratory. "In the post-genomic era, scientists are in need of a tool that will analyze and deliver the vast quantity of available information and diverse databases in a comprehensive and integrated manner," said Dr. Mor Amitai, president and CEO (1) (Chief Executive Officer) The highest individual in command of an organization. Typically the president of the company, the CEO reports to the Chairman of the Board. , Compugen. "We believe that Gencarta will enhance genomic research and discovery and will meaningfully contribute to the drug development process." Using Gencarta intuitive viewers, users will be able to query and browse the genome, with access to data of interest on several levels. The genomic level includes information concerning genes and pseudogenes, repeats, CpG islands CpG islands are genomic regions that contain a high frequency of CG dinucleotides. In mammalian genomes, CpG islands are typically 300-3,000 base pairs in length. They are in and near approximately 40% of promoters of mammalian genes (about 70% in human promoters). , SNPs, enhancers, and promoters. The transcript level includes information regarding splice variants, aligned ESTs and mRNAs. Each splice variant is then further annotated with information about homologues, SAGE-based expression profiles, open reading frames, sequence translation and detailed domain summaries. Gencarta is expected to be commercially available for corporate installation at high throughput laboratories in the first quarter of 2001. It will be available on subscription bases with periodic updates. About Compugen Compugen (http://www.cgen.com) is a pioneer in the field of computational genomics Computational genomics is the study of deciphering biology from genome sequences using computational analysis.[1], including both DNA and RNA. Computational genomics focuses on understanding the human genome, and more generally the principles of how DNA controls the and proteomics. Based on a unique combination of advanced mathematics, computer science and molecular biology, Compugen develops proprietary comprehensive platforms to improve and accelerate life science research. These platforms are provided to leading organizations such as Pfizer, Human Genome Sciences Human Genome Sciences NASDAQ: HGSI is a biopharmaceutical corporation founded in 1992. Its stated purpose is to "discover, develop, manufacture and market innovative drugs that serve patients with unmet medical needs, with a primary focus on protein and antibody drugs. , Inc. and the U.S. Patent and Trademark Office to significantly enhance and accelerate their research efforts in the discovery of drugs, therapeutics, diagnostics and agricultural products and in their general understanding of biological data of all types. Through its LabOnWeb.com Web site, Compugen has begun to provide certain components of its platforms to individual molecular biologists and other life scientists worldwide. In addition, Compugen has recently established its Novel Genomics division to commercialize, mainly through licensing arrangements, some of the genes and proteins that it discovers in its own research efforts. For more information, call 972-3-765-8120 or email to tsipi@cgen.com. |
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