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The Blueprint Initiative research program, led by Principal Investigator Noun 1. principal investigator - the scientist in charge of an experiment or research project
PI

scientist - a person with advanced knowledge of one or more sciences
 Dr. Christopher Dr. John R. Christopher, known popularly as "Dr. Christopher" was one of very few nationally prominent doctors of herbal medicine of the middle third of the 20th century, a "dark ages" of herbalism and was responsible for the herbal renaissance of the 1960s.  Hogue at Mount Sinai Hospital's Samuel Lunenfeld Research Institute The Samuel Lunenfeld Research Institute of Mount Sinai Hospital (Toronto), Ontario, Canada was established in 1985 by an endowment from the Lunenfeld and Kunin families. It comprises 31 principal investigators, has a budget of C$90 million (2005/6), has 225 trainees and over 550 , Toronto, has secured CDN (Content Delivery Network) A system of distributed content on a large intranet or the public Internet in which copies of content are replicated and cached throughout the network.  $29 million in government and public funding Public funding is money given from tax revenue or other governmental sources to an individual, organization, or entity. See also
  • Public funding of sports venues
  • Research funding
  • Funding body
 to enter 80,000 molecular interaction records into the Biomolecular Interaction Network Database (BIND.CA).

Genome Canada in partnership with the Ontario Government's Research and Development Challenge Fund, the Canadian Institutes of Health Research Canadian Institutes of Health Research (CIHR) is the major federal agency responsible for funding health research in Canada. It is the successor to the Medical Research Council of Canada.  and industry partners Sun Microsystems Sun Microsystems, Inc. (NASDAQ: JAVA[3]) is an American vendor of computers, computer components, computer software, and information-technology services, founded on 24 February 1982. , MDS MDS,
n See temporomandibular pain-dysfunction syndrome.

MDS 1 Maternal deprivation syndrome, see there 2 Myelodysplastic syndrome, see there
 Proteomics and Foundry Networks Foundry Networks is a network system vendor selling high-end managed ethernet switches and routers. The company was founded in 1996 by Bobby R. Johnson, Jr. and is based in Santa Clara, California, USA.  are to fund Blueprint's BIND software development, database curation, computer hardware and networking.

"Genome Canada's contribution to The Blueprint Initiative represents one of our largest investments in Ontario to date," said Dr. Martin Godbout, president and CEO (1) (Chief Executive Officer) The highest individual in command of an organization. Typically the president of the company, the CEO reports to the Chairman of the Board.  of Genome Canada. "Dr. Hogue's vision to assemble man's biomolecular knowledge on one open source database for all researchers to access free of charge is arresting. Moreover, his commitment to concrete deliverables and his capacity to produce promised results on time and on budget set the standard for scientific public good research in Canada and around the world."

In this manner, BIND will become the world's most comprehensive repository of data and research about molecular interactions and reactions in humans and other organisms studied by scientists in some 16 different fields. This information will help scientists worldwide understand how the molecular complexity inside cells assembles together to form whole cells - the true blueprint of life.

"The Blueprint Initiative is a major and exciting 'first' for Canada and the world," said Dr. Alan Bernstein, president of the Canadian Institutes of Health Research. "It will enable researchers to have free access to an important source of new data to better understand the molecular recipe of life and how it affects human health and disease."

"We are working hard to keep Ontario's economy one of the strongest in the world, to improve the quality of life for Ontarians. Making Ontario a focal point focal point
n.
See focus.
 for this research project will lead to a stronger economy, leading-edge health research and improved health services health services Managed care The benefits covered under a health contract  for the people of this province and the world," said Ontario's Minister of Enterprise, Opportunity and Innovation, Jim Flaherty James Michael "Jim" Flaherty, PC, BA, LL.B, MP (born December 30, 1949) is Canada's Minister of Finance; he had formerly served as Ontario's Minister of Finance.

.From 1995 until 2005 he was the Member of Provincial Parliament for Whitby—Ajax, representing the
. "Our government is fully committed to investing in R&D. This partnership investment will put Ontario on course to become a worldwide centre for proteomic data management and research. I am pleased that our government is able to provide continuing support to this exciting project."

Blueprint's funding is contingent on achieving set milestones, deliverables and quality for both software releases and for database content. With Blueprint's funding now certain, BIND is poised to become the largest free database in the field of proteomics. The BIND database and its associated software tools are easily accessible to both academics and commercial companies worldwide.

Blueprint's Principal Investigator, Christopher Hogue said, "prior to this announcement, BIND funding was limited to prototypes built by graduate students with limited abilities to build and maintain software systems for the public."

He adds, "it was largely thanks to Sun Microsystems who delivered the crucial support needed to assure government funding so that we can offer this public research service." Having secured this funding, Dr. Hogue becomes one of the most highly funded international bioinformatics researchers, and bears the responsibility for serving the worldwide public interest in collecting and distributing mankind's biomolecular assembly knowledge.

The Blueprint has a staff of 59 that will grow to 77 by 2005. Currently, the staff consists of 12 database curators who identify, analyze and record protein interactions in BIND and 29 software developers. Dr. Hogue is supported by co-principal investigators Dr. Tony Pawson from the Samuel Lunenfeld Research Institute at Mount Sinai Hospital Mount Sinai Hospital can refer to:
  • Mount Sinai Hospital (Toronto)
  • Mount Sinai Hospital, New York
  • Mount Sinai Medical Center & Miami Heart Institute
  • Mount Sinai Hospital, Cleveland
  • Mount Sinai Hospital, Chicago
  • Mount Sinai Hospital, Milwaukee
 and Francis Ouellette from the University of British Columbia Locations
Vancouver
The Vancouver campus is located at Point Grey, a twenty-minute drive from downtown Vancouver. It is near several beaches and has views of the North Shore mountains. The 7.
 Bioinformatics Centre as well as the Blueprint Scientific Advisory Chair Dr. Boris Steipe from the Department of Biochemistry of the University of Toronto Research at the University of Toronto has been responsible for the world's first electronic heart pacemaker, artificial larynx, single-lung transplant, nerve transplant, artificial pancreas, chemical laser, G-suit, the first practical electron microscope, the first cloning of T-cells, . Membership on Blueprint's Scientific Advisory Group will be announced in the coming weeks.

"Blueprint is making one of the only serious efforts at collecting, carefully curating and providing information to scientists that would not otherwise be made available in a computer-readable format. Over the long term, I am confident that BIND will allow scientists to have at their fingertips "Fingertips" is a 1963 number-one hit single recorded live by "Little" Stevie Wonder for Motown's Tamla label. Wonder's first hit single, "Fingertips" was the first live, non-studio recording to reach number-one on the Billboard Pop Singles chart in the United States.  a complete picture of the mechanisms that drive the molecules of biology," said Dr. Tony Pawson.

About BIND

The BIND database is being built-up from peer-reviewed literature and from direct submissions, based on the world's most comprehensive integrated bioinformatics standards, including those used by the US National Centre for Biotechnology Information (NCBI NCBI National Center for Biotechnology Information (NIH)
NCBI National Coalition Building Institute
NCBI National Council for the Blind of Ireland (Dublin, Ireland) 
) for storing biomolecular sequence, taxonomy, structure and literature information.

BIND's data model was the first of its kind to be peer-reviewed prior to database development, and is now a mature standard data format spanning molecular interactions, small molecule chemical reactions, interfaces from three-dimensional structures and genetic interaction networks. PreBIND, one of many bioinformatics tools developed at Blueprint, can be used to find information about interactions involving proteins of interest from major model organisms, prior to their curation into the BIND database.

About The Samuel Lunenfeld Research Institute

Established in 1985, The Samuel Lunenfeld Research Institute (SLRI SLRI Samuel Lunenfeld Research Institute (Toronto) ) at Mount Sinai Hospital in Toronto is one of the world's leading centres for biomedical research. The Institute is part of Mount Sinai Hospital, an internationally recognized 440-bed acute care academic health centre affiliated with the University of Toronto. SLRI has 513 research, administrative and support staff, 100,000 square feet of laboratory space and a 25,000 square foot pre-clinical research lab.

For more information about SLRI research visit http://www.mshri.on.ca.

About Mount Sinai Hospital

Mount Sinai Hospital is recognized nationally and internationally for its excellence in the provision of compassionate patient care, teaching and research. Its key priority programs are Women's and Infants' Health, Surgical Subspecialties and Oncology, Internal Medicine and Subspecialties, and the Samuel Lunenfeld Research Institute. It is a University of Toronto-affiliated patient care, teaching and research centre.

For more information, visit http://www.mtsinai.on.ca.

About Genome Canada

Genome Canada is the primary funding and information resource relating to genomics and proteomics in Canada. Dedicated to developing and implementing a national strategy in genomics and proteomics research for the benefit of all Canadians, it has so far received $375 million from the Government of Canada The Government of Canada is the federal government of Canada. The powers and structure of the federal government are set out in the Constitution of Canada.

In modern Canadian use, the term "government" (or "federal government") refers broadly to the cabinet of the day and
. Genome Canada has established five Genome Centres across the country (Atlantic, Quebec, Ontario, Prairies and British Columbia) and has as a main objective to ensure that Canada becomes a world leader in genomics and proteomics research. Together with its five Genome Centres and with other partners, Genome Canada invests and manages large-scale research projects in key selected areas such as agriculture, environment, fisheries, forestry, health and new technology development. Genome Canada also supports research projects aimed at studying and analyzing the ethical, environmental, economic, legal and social issues related to genomics research (GE3LS).

About the Ontario Research and Development Challenge Fund

Created in 1997 by the Ontario government, the Ontario Research and Development Challenge Fund promotes world-class research of interest to the private sector; encourages collaboration between the private sector and research institutions; attracts and retains top scientists and enables talented young scientists to pursue their research interests; and helps Ontario's research institutions build their R&D capacity, so they are able to obtain funding from other sources. The Ontario government has committed over $1.2 billion to the Challenge Fund for investing in leading-edge R&D. Through the Challenge Fund, the province has invested $453 million in 104 research projects. Private sector and research institution partners are investing an additional $1.2 billion bringing the total value of Challenge Fund supported research projects to over $1.6 billion.

About Canadian Institutes of Health Research (CIHR CIHR Canadian Institutes of Health Research
CIHR Cambodian Institute of Human Rights
)

The Canadian Institutes of Health Research is the Government of Canada's premier agency for health research. Its objective is to excel, according to internationally accepted standards of scientific excellence, in the creation of new knowledge and its translation into improved health for Canadians, more effective health services and products and a strengthened Canadian health care system.

For more information, call (416)596-7955.
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