BIND CURATION PUTS DATA INTO BIOINFORMATION CONTEXT.BIND curation Cu`ra´tion n. 1. Cure; healing. effort builds on earlier experimental work to put data into bioinformatics context. Following on the efforts of researchers at the University of Toronto Research at the University of Toronto has been responsible for the world's first electronic heart pacemaker, artificial larynx, single-lung transplant, nerve transplant, artificial pancreas, chemical laser, G-suit, the first practical electron microscope, the first cloning of T-cells, , the Hospital for Sick Children, and Affinium Pharmaceuticals to describe an interactome map of conserved and essential E. coli E. coli: see Escherichia coli. E. coli in full Escherichia coli Species of bacterium that inhabits the stomach and intestines. E. coli can be transmitted by water, milk, food, or flies and other insects. proteins, The Blueprint Initiative has announced that scientists at its Toronto node have curated this data into the freely available, open-source Biomolecular Interaction Network Database (BIND). The newly curated data is comprised of 435 molecular complexes, first identified by tandem affinity purification The Tandem Affinity Purification (TAP) method involves the fusion of the TAP tag to the C-terminus of the new protein. The TAP tag consists of calmodulin binding peptide (CBP) from the N-terminal, followed by tobacco etch virus protease (TEV protease) cleavage site and Protein A, or sequential peptide affinity, involving 2262 protein interactions. These interactions include 148 ribosomal complex interactions and 163 degradosomal complex interactions (typically involving chaperonins), systems that are critical to cellular function. For more information, call 416/596-6266 or visit http://www.blueprint.org. |
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