BG Medicine Acquires Exclusive Commercial Rights to Biomarker of Vascular Plaque Rupture from ACS Biomarker.BG Medicine plans to develop and commercialize diagnostic tests to aid in early diagnosis of acute cardiac and cerebral disorders WALTHAM, Mass. & MAASTRICHT, The Netherlands -- BG Medicine, Inc. (BG Medicine) and ACS (Asynchronous Communications Server) See network access server. Biomarker B.V. (ACS Biomarker) today announced that they have entered into an agreement pursuant to which BG Medicine obtained rights to develop and commercialize a novel clinical diagnostic test for acute atherothrombosis based on a biomarker discovered by the Cardiovascular Research Institute Maastricht (CARIM). Under the terms of the agreement, ACS Biomarker has granted BG Medicine exclusive, worldwide commercial rights to pursue the development, validation, regulatory approval and commercialization of diagnostic tests based on the biomarker discovered by CARIM, in exchange for milestone payments, royalties based on net sales Net Sales The amount a seller receives from the buyer after costs associated with the sale are deducted. Notes: This amount is calculated by subtracting the following items from gross sales: merchandise returned for credit, allowances for damaged or missing goods, freight and sublicensing income of any products commercialized under the license. Atherothrombosis occurs when vascular plaque ruptures leading to thrombosis thrombosis (thrŏmbō`sĭs), obstruction of an artery or vein by a blood clot (thrombus). Arterial thrombosis is generally more serious because the supply of oxygen and nutrition to an area of the body is halted. , or clotting, in the affected artery, which in turn can progress to life-threatening conditions such as heart attacks and stroke. The underlying condition is usually asymptomatic until the presentation of a serious or life-threatening event, resulting from the rupture. The novel test that BG Medicine expects to develop aims to use the biomarker discovered by CARIM to identify plaque rupture in patients early, for instance, when the blockage is temporary or not complete and has not yet caused the common signs and symptoms of heart attack or stroke. Specifically, the test aims to aid in the diagnosis of less severe or transient conditions such as Transient Ischemic Attacks Transient Ischemic Attack Definition A transient ischemic attack, or TIA, is often described as a mini-stroke. Unlike a stroke, however, the symptoms can disappear within a few minutes. (TIAs), cerebrovascular cer·e·bro·vas·cu·lar adj. Relating to the blood supply to the brain, particularly with reference to pathological changes. cerebrovascular pertaining to the blood vessels of the cerebrum or brain. disorders that are often considered "warning-strokes" which produce stroke-like symptoms, and unstable angina un·sta·ble angina n. Angina pectoris characterized by pain of coronary origin that occurs in response to less exercise or other stimuli than usually required to produce pain. , which is the sudden increase of blockage in a coronary artery coronary artery n. 1. An artery with origin in the right aortic sinus; with distribution to the right side of the heart in the coronary sulcus, and with branches to the right atrium and ventricle, including the atrioventricular branches and caused by a blood clot blood clot n. A semisolid, gelatinous mass of coagulated blood that consists of red blood cells, white blood cells, and platelets in a fibrin network. . These conditions are often precursors to heart attacks, strokes or other major cardiac events. For example, a TIA (1) (Telecommunications Industry Association, Arlington, VA, www.tiaonline.org) A membership organization founded in 1988 that sets telecommunications standards worldwide. It was originally an EIA working group that was spun off and merged with the U.S. is followed by a stroke in 10% of patients within 90 days after the TIA. The test may also provide reliable data in the early hours following a heart attack when current tests are not reliable. ACS Biomarker, a company that was formed with technology exclusively licensed from the University of Maastricht and other parties, was founded to develop and commercialize cardiovascular biomarkers discovered at CARIM. The biomarker licensed to BG Medicine from ACS Biomarker was discovered by Professor Mat Daemen, who is one of the founders of ACS Biomarker and Scientific Director of CARIM. This is the second agreement between BG Medicine and ACS Biomarker. In May 2007, BG Medicine acquired the exclusive rights to develop and commercialize diagnostic tests for congestive heart failure congestive heart failure, inability of the heart to expel sufficient blood to keep pace with the metabolic demands of the body. In the healthy individual the heart can tolerate large increases of workload for a considerable length of time. based on certain, other biomarkers that it licensed from ACS Biomarker. About Biomarkers A biomarker is one or more biological characteristics that are objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes or pharmacological responses to a therapeutic intervention, such as the administration of a drug. Since biomarkers correlate with an underlying process within the body, tests to measure biomarkers can be used effectively to inform physicians on treatment decisions. A molecular diagnostic test is a product based on these biomarkers that is intended to provide information to physicians that will improve patient treatment decisions. About ACS Biomarker ACS Biomarker B.V. is a spin-off from the University of Maastricht and the technology transfer organization BioMedbooster. ACS Biomarker was established for the development and commercialization of cardiovascular biomarkers discovered at CARIM. ACS Biomarker draws upon a proprietary large scale lead-identification strategy to identify novel markers to serve as molecular probes Molecular Probes is a biotechnology company located in Eugene, Oregon specializing in fluorescence. The company was founded in 1975 by Richard and Rosaria Haugland in their kitchen in Minnesota, then moved briefly to Texas and finally to Oregon in the early 1980s. of early vascular and cardiac disease. ACS Biomarker aims to be the first in delivering clinical proof for novel biomarkers that can help the physician to recognize disease before their patient does. About BG Medicine BG Medicine is a life sciences company focused on the discovery, development and commercialization of novel molecular diagnostics based on biomarkers to improve patient outcomes and contain healthcare costs. BG Medicine discovers biomarkers and is developing its diagnostic product candidates using its proprietary, versatile, and scalable technology platform, which integrates and automates the precise measurement, analysis, characterization and interpretation of proteins and metabolites Metabolites Substances produced by metabolism or by a metabolic process. Mentioned in: Interactions collected from bodily fluids. |
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