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BAXTER, CANTAB EXPAND COLLABORATION ON ANTI-CD45 ANTIBODY TO PREVENT ORGAN-TRANSPLANT REJECTION

 DEERFIELD, Ill., July 12 /PRNewswire/ -- Baxter Healthcare Corporation and Cantab Pharmaceuticals plc (NASDAQ: CNTBY) announced today that they have agreed to expand their collaboration on the development and marketing of anti-CD45, a drug that is being tested as a way to prevent acute rejection episodes following organ transplantation.
 Under the new agreement, Baxter receives exclusive worldwide manufacturing rights for anti-CD45 and exclusive rights to market the product in Japan and in Pacific Rim nations. Baxter also maintains its existing exclusive rights under a 1991 agreement to market anti-CD45 in North America and Europe. Baxter will pay Cantab a licensing fee, royalties on future sales and payments based on achieving research milestones. The companies have collaborated on anti-CD45 since 1991.
 In April 1993, the companies presented favorable results of a phase I/II clinical trial of the drug. The study involved patients in the United Kingdom who were undergoing kidney transplants. The companies expect to begin expanded clinical trials in the United Kingdom later this year.
 "Since the commencement of our collaboration two years ago we have been impressed by the potential for Baxter to apply its considerable manufacturing resources to accelerate the development of anti-CD45," said Paul Haycock, M.D., president and chief executive officer of Cantab. "In addition, our evaluation of the future opportunity of anti- CD45 in Japan and the Far East has shown that Baxter is very well placed to carry out clinical development and marketing of the drug there, as well as in North America and Europe."
 Every year, more than 20,000 people around the world undergo kidney transplants and more than half of these patients suffer episodes of acute rejection of the transplanted organ. While current practice for treating acute rejection uses drugs to suppress the patient's immune system after transplantation, anti-CD45 is used to prevent rejection by treating the donor organ before it is transplanted. Scientists believe that acute rejection episodes are caused in part by the kidney's dendritic cells, which carry a protein known as the CD45 antigen. Researchers at Cantab, in collaboration with Cambridge University, have developed a pair of monoclonal antibodies (anti-CD45) that bind to the CD45 antigen and are designed to destroy the dendritic cells. The drug is used ex vivo (outside the body) to pre-treat the donor organ before transplantation.
 "We are encouraged by the initial results of our clinical trials," said Donald W. Joseph, president of Baxter's Renal Division. "The expansion of our agreement with Cantab strengthens our commitment to global innovation and leadership in the field of kidney disease."
 "Baxter has extensive experience in manufacturing this type of product," Dr. Haycock said. Baxter has developed a process for producing anti-CD45 at its Biotech Group facilities in California. The company also has strong relationships with nephrologists in Japan and the Far East through its programs for developing and marketing peritoneal dialysis products and services. As the worldwide leader in dialysis products and services, Baxter is well position to bring new products to the transplant community. The company announced in May that it plans to introduce a line of tissue-typing diagnostic products for transplant physicians.
 Cantab is engaged in the research and development of biopharmaceuticals that use the highly selective properties of the immune system to treat disease. It is developing Leukocyte Modulators, which regulate or block immune-system function, and Therapeutic Antigens, which activate specific immune responses. Beyond anti-CD45, Cantab has programs in the treatment of cervical cancer, the prevention of recurrence of genital herpes, the treatment of genital warts and research into the management of Crohn's disease. The company has established unique collaborations with researchers at the universities of Cambridge and Oxford.
 Baxter Healthcare Corporation is the principal domestic operating subsidiary of Deerfield, Ill.-based Baxter International Inc. (NYSE: BAX). Through its subsidiaries, Baxter is the leading manufacturer and marketer of health-care products, systems and services worldwide. The company offers 120,000 products to health-care providers in 100 countries.
 -0- 7/12/93
 /CONTACT: Geoffrey Fenton of Baxter, 708-948-3436; or Paul Haycock, Ph.D., of Cantab, 011-44-223-423413; or Anthony J. Russo, Ph.D., of Noonan/Russo Communications, 212-979-9180, for Cantab/
 (BAX CNTB)


CO: Baxter International Inc.; Cantab Pharmaceuticals plc ST: Illinois IN: MTC SU:

WB -- NY042 -- 0400 07/12/93 12:00 EDT
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