Avila Therapeutics, Inc. Closes $30 Million Series B Financing.Company to Advance Novel Class of Protein-Silencing Covalent co·va·lent adj. Of or relating to a chemical bond characterized by one or more pairs of shared electrons. Drugs into Clinic Development WALTHAM, Mass. -- Avila Therapeutics, Inc., an emerging biotechnology company, announced today that it has raised $30 million in a Series B equity financing Equity Financing The act of raising money for company activities by selling common or preferred stock to individual or institutional investors. In return for the money paid, shareholders receive ownership interests in the corporation. . The Novartis Option Fund, a new investor, led the round and all existing Avila investors participated: Abingworth, Advent Venture Partners, Atlas Venture Atlas Venture is an international early-stage venture capital firm that invests in communications, information technology, and life sciences companies. Atlas Venture has investing offices in Boston, London, Munich, and Paris, and its investments are evenly divided between the and Polaris Venture Partners. Avila's powerful platform technology, which was designed to create a broad set of covalent drug product opportunities that fight disease through protein silencing, has demonstrated preclinical activity with two programs, one targeting hepatitis C virus
pro·te·ase n. Any of various enzymes, including the proteinases and peptidases, that catalyze the hydrolytic breakdown of proteins. and the other targeting Btk, an emerging target in autoimmune disease autoimmune disease, any of a number of abnormal conditions caused when the body produces antibodies to its own substances. In rheumatoid arthritis, a group of antibody molecules called collectively RF, or rheumatoid factor, is complexed to the individual's own gamma and certain cancers, and has also generated multiple additional early-stage programs across a range of targets. "Avila's innovations and proprietary know-how make it possible to intelligently pursue covalent drugs, a broad product class that has been underutilized to date. The Avila team has already developed promising drug candidates against important targets in cancer, autoimmune disease and hepatitis C Hepatitis C Definition Hepatitis C is a form of liver inflammation that causes primarily a long-lasting (chronic) disease. Acute (newly developed) hepatitis C is rarely observed as the early disease is generally quite mild. , and we see opportunities for Avila's platform to be applied to many target types across a range of diseases," said Henry Skinner Henry Alfred 'Harrie' Skinner was the RACA’s founder and first Honorary Life Member. He introduced the first gramophone to Sydney, he was a photographic pioneer, he managed a circus and then some of the great variety acts of the day, and of course he was the founding force , Ph.D., Managing Director of the Novartis Option Fund. "I look forward to working with Avila's leadership team as they move programs forward that have the potential to offer a truly significant advance over current treatments." "With the Novartis Option Fund we are very pleased to expand our circle of industry-leading investors," said Katrine S. Bosley, CEO (1) (Chief Executive Officer) The highest individual in command of an organization. Typically the president of the company, the CEO reports to the Chairman of the Board. of Avila Therapeutics. "Avila has made tremendous progress in developing and demonstrating the promise of covalent drugs. This financing provides us with a strong financial foundation and firmly validates our investors' belief in Avila's future and the best-in-class potential of covalent drugs." Proceeds from the financing will be used to advance Avila's first program into clinical development while continuing to advance the proprietary Avilomics[TM] drug discovery platform. In conjunction with this financing transaction, Henry Skinner, Ph.D., Managing Director of the Novartis Option Fund, has joined the Avila board of directors. He joins board members Daniel Lynch (Executive Chairman); Michael F. Bigham (Abingworth); Bruce L. Booth, D.Phil. (Atlas Venture); Katrine Bosley; Roy Lobb, D.Phil.; Amir Nashat, Ph.D. (Polaris Venture Partners); Raj Parekh, D.Phil. (Advent Venture Partners) and Vicki Sato, Ph.D. About the Avilomics[TM] Platform and Covalent Drugs With broad applicability across multiple disease areas, the Avilomics platform is Avila's powerful approach to design and develop selective drugs with superior pharmacology. The three components of Avilomics are: i) proprietary informatics Same as information technology and information systems. The term is more widely used in Europe. technologies that uniquely identify sites amenable to selective covalent modification and target silencing, ii) a unique library of highly selective chemistries for target silencing, and iii) design tools that integrate target analysis and covalent chemistry to create novel medicines. Together, these components provide a platform for efficient design and testing that yields covalent drug candidates with broad applicability to a variety of targets and diseases. Using Avilomics, the company designs and develops covalent drugs that strongly, selectively, and resiliently bond to disease-causing proteins, thereby silencing their activity and producing superior pharmacological outcomes. About Avila Therapeutics[TM], Inc. Avila Therapeutics is developing an innovative and proprietary therapeutic approach to covalent drug development, called "protein silencing". Avila's science has the potential to deliver covalent drugs with unique therapeutic benefits because they are highly targeted, are effective against mutations in disease targets, and have long duration of action. The company is developing a pipeline of novel, protein-silencing covalent drugs with a current focus on viral infection viral infection, n an infection by a pathogenic virus. A virus acts on the cell nucleus, taking over the genetic material within the nucleus and replicating itself. , cancer and autoimmune disease. Avila is funded by leading venture capital firms Name Location Founding date Managing Partners/Directors Specialty Capital managed 5AM Ventures Menlo Park, CA; Waltham, MA 2002 John Diekman, PhD (managing partner), Scott Rocklage, PhD (managing partner), Andrew Schwab (managing partner) life sciences $200M [1] : Abingworth, Advent Venture Partners, Atlas Ventures, Novartis Option Fund, and Polaris Venture Partners. For additional information, please visit http://www.avilatx.com. About the Novartis Option Fund The Novartis Option Fund is a $200 million fund that is part of the Novartis Venture Funds. Established in 1996, the Novartis Venture Funds currently manage over $650 million in committed capital and is invested in more than 50 private companies. The objective of the Novartis Option Fund is to seed innovative companies through initial and follow on investments. The initial investment is coupled with an option to a specific therapeutic program providing early validation for the company's technology by a larger pharmaceutical partner. The Novartis Venture Funds' team of eight investment professionals located in Basel, Switzerland and Cambridge, Massachusetts This article is about the city of Cambridge in Massachusetts. For the English university town, see Cambridge, England. For other places, see Cambridge (disambiguation). Cambridge, Massachusetts is a city in the Greater Boston area of Massachusetts, United States. , brings together extensive expertise in the biotech and pharmaceutical industry and venture capital. |
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