Autologous and cancer stem cell gene therapy.9789812775863 Autologous autologous /au·tol·o·gous/ (aw-tol´ah-gus) related to self; belonging to the same organism. au·tol·o·gous adj. 1. and cancer stem cell Cancer stem cell hypothesis states that tumors arise from cells termed cancer stem cells that have properties of adult stem cells, particularly the abilities to self-renew and differentiate into multiple cell types, and that these cells persist in tumors as a distinct population gene therapy. Ed. by Roger Bertolotti and Keiya Ozawa. World Scientific 2008 446 pages $102.00 Hardcover Progress in gene therapy; v.3 QH588 They clone themselves to replace tissues and organs, so stem cells contain possibilities for both cures and cancers. Therefore, this collection of 15 articles describes treatments for acquired or inherited diseases and effective anti-cancer therapies that use our new understanding of the "dark side" of stem cells. They address the move toward a universal platform for autologous stem cell gene therapy and also address adenosine deaminase deficiency adenosine deaminase deficiency ADA deficiency A uniformly fatal AD disease, which consitutes 40% of Pts with SCID Clinical Cellular immune dysfunction, oral candidiasis, intractable diarrhea, FTT, severe diaper rash, pseudoachondrodysplasia, death by age 2 Lab , insertion of a transgene into Chromosome 19, site-specific integrating vectors, gene targeting, engineering of homing endonucleases and novel sequence-specific DNA DNA: see nucleic acid. DNA or deoxyribonucleic acid One of two types of nucleic acid (the other is RNA); a complex organic compound found in all living cells and many viruses. It is the chemical substance of genes. binding and modifying, gene targeting mediated by hyper-dependent adenoviral vectors, and multipotent progenitor cells. Papers on cancer therapy and armed stem cells cover such topics as CD44 as a marker and target, therapy of primary and metastatic solid tumors, antitumor activities of certain CD34+ cells, mesenchymal stem cells as vehicles for delivering therapeutics and oncolytic viruses, and mammary mammary /mam·ma·ry/ (mam´ah-re) pertaining to the mammary gland, or breast. mam·ma·ry adj. Of or relating to a breast or mamma. mammary pertaining to the mammary gland. , brain and leukemia stem cells. ([c]20082005 Book News, Inc., Portland, OR) |
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