Auto-Immune Disease and the Internal Shock Response to Nutrient Inhibitors, Viewed Through God's Blueprints:

This Hypothesis traces out the Internal Response, to excessive consumption of Nutrient Inhibitors creating an inability to absorb Nutrients, through God's Blueprints, via the three Stages of Shock and how it resembles Auto-Immune Disease.. I have tried to map out what I believe is the initial step down the pathway into Autoimmune Disease... I believe it is the excessive consumption of Calcium and Iron Nutrient Inhibitors which opens the door to disruptions in Capillary Exchange, Cellular Communication and Fluid Levels between Compartments... And finally how the disrupted Osmotic Pressure disrupts filtration and ends up blocking or nullifying the Parathyroid Hormone/ Calcitonin Negative Feedback Loop for regulating the Calcium/Phosphate balance..

I am not a Doctor and this contains no Medical Advice, just food for thought to open up the pathway to discussion...

My definition of Auto-Immune Disease:
I believe excessive consumption of Nutrient Inhibitors is serving as an artificial filter that is altering blood chemistry.. This altered blood is insufficient for cell use and is causing "Cell Nutrient Starvation" which becomes a silent "Internal Stressor" that activates the "Shock Response" which triggers the General Adaptation Syndrome in a "Fight or Flight Stress Response", which resets the Internal Environment to abnormal levels... Long-term activation of these attempted corrections cause exhaustion and wears down the Internal Systems created by God, and eventually symptoms start to manifest... As the symptoms manifest, the medical community is alerted and they view these abnormal settings as Auto-Immune Diseases such as: Aids, Alzheimer's, Anorexia, Arteriosclerosis, Arthritis, Autism, Birth Defects, Blood Disorders, Bone Diseases, Brain Disorders, Cancer, Cartilage Disorders, Diabetes, Edema, Enzyme Disorders, Epilepsy, Gastrointestinal Disorders, Heart Disease, High and Low Blood Pressure, Hormone Disorders, Immune System Disruptions, Kidney Disorders, Lupus, Mitochondria Disorders, Multiple Sclerosis, Multiple Dystrophy, Muscle Disruptions, Myasthenia Gravis, Nervous System Disorders, Nutritional Disorders, Obesity, Osteoporosis, Pancreas Disorders, Parkinson's, Schizophrenia, Scleroderma, Sleep Disorders, Stem Cell Disruptions, etc...

Autoimmune Trigger:
Calcium and Iron in the body are turned into salts and complexes that are insoluble in the presence of the Nutrient Inhibitors Oxalic and Phytic acids, such as are reported to be found in Soy... (I believe the long-term excessive consumption of these Nutrient Inhibitors, which are saturating the processed food-chain, would be enough to alter the Ion concentration and blood chemistry at the cell level.).. Calcium bound in insoluble calcium salts cannot be utilized, by the cells.. An Electrolyte imbalance would denature the functional proteins and this disrupts hemoglobin's ability to transport oxygen... Iron is the part of hemoglobin responsible for oxygen delivery... Inability to utilize Iron bound in insoluble complexes to transport oxygen could result in an oxygen deficiency in the Cellular Respiration Electron Transport.. This would result in disrupted ATP metabolism and this would cause excessive Hydrogen Ions, Pyruvic and Lactic Acids, causing Acidosis... Lysosomes become fragile, rupture and burst when deficient in oxygen and release nerve cell destroying enzymes and when they rupture in joints they destroy cartilage... If the heart muscle becomes deficient in Calcium ions, the heart pumping is insufficient.. Combined, weak pumping by the heart muscle, denatured hemoglobin and insoluble Iron complexes will enhance an oxygen deficiency...

(As you will be able to see these symptoms seem to be parallel to those found in the II Stage of Shock.. Which is the Stage when the Internal Systems have been unable to return the body back to Homeostasis and the symptoms finally start to alert the Medical Community and draw them into the fray. I believe Cell Nutrient Starvation, caused by Nutrient Inhibitors, is Shock being played out in very slow motion... Cell Nutrient Starvation is not the fast pace Shock that is normally thought of, but the pathways of decline seem to be the same)...

Parallels between Internal Shock and Autoimmune Disease:
The Shock Feedback System is activated when blood strength is lost and the Cardiovascular System becomes unable to deliver enough nutrients to the cells for them to fulfill their metabolic needs.. Cell metabolism is disrupted and the membranes malfunction... This causes the Autonomic Nervous System to
respond by stimulating the Sympathetic Division to instantly instigate powerful responses through Negative Feedback Systems to make compensations in the 1st Stage of Nonprogressive Compensated Shock ..
(I believe the Nutrient Inhibitors alteration of the blood chemistry causes the lost of blood strength which would register in the Internal Systems as being similar to hemorrhaging and/or low blood pressure, because the true blood is just not there.. Since the symptoms of insufficient nutrients resemble hemorrhaging and/or low blood pressure, the Internal Response would be, the Shock and Low Blood Pressure Negative Feedback Responses)..

Responses from the 1st Stage of Compensated Shock :
#1. Sympathetic Responses from the ANS: Cause vasoconstriction in blood vessels of the skin, kidneys and abdominal organs which raises Systemic Vascular Resistance(SVR).. Hormones Epinephrine and Norepinephrine secretion is increased, and heart rate and contraction force is increased resulting in increased blood pressure..
#2. Deficient blood flow to kidneys, make them release Renin and this triggers the Renin-Angiotensin Pathway... As a result Angiotensin II, which is a very powerful vasoconstrictor of small arteries, is released.. Angiotensin II stimulates Aldosterone secretion.. Aldosterone causes an increase in blood volume by enhancing kidney reabsorption of Na+ and water, and raises blood pressure...
#3. Low blood pressure initiates increased Antidiuretic Hormone (ADH) secretion, which stimulates water retention and vasoconstriction..
#4. When cells are affected by deficient Oxygen (hypoxia) they release vasodilators to relax the ring of cells that regulate blood flow into true capillaries (precapillary sphincters) and expand the small arteries... In a normal situation, the blood flow increases to the area would return the oxygen levels to normal...(But the Nutrient Inhibitors makes the situation abnormal)... Vasodilation can play a harmful role in a low blood pressure situation, because it can allow the (SVR) and blood pressure to drop.. (Since the Nutrient Inhibitors would continue to have their effect on the absorption of Calcium, Iron and other nutrients, the heart muscle would continue to weaken, cardiac output would remain insufficient and the chemical composition of the blood arriving to the heart muscle tissue and cells would remain inadequate.... Lack of blood (Ischemia), due to the incorrect chemical composition would progressively depress the Vasomotor Center's activities, the Cardiac output would continue to diminish and the blood pressure would still appear to be dropping, to the Internal Systems, since the strength in the blood continues to decline.. In my opinion, the General Adaptation Syndrome would have to raise the threshold for blood pressure to a higher level to compensate for the altered chemical composition of the blood and this would mask the low blood pressure from the human eye, yet the blood remains inadequate... I believe this is the beginning of where the Medical Community starts their misinterpretations... The Nutrient Inhibitors would not allow the normalization of oxygen levels due to the denatured hemoglobin and Insoluble Iron Complexes and deficient calcium in the heart muscle contractions... So if the 1st stage of Shock cannot compensate for the lost nutrients and beat the wolf back from the door, then the II Stage of Decompensated Progressive Shock is entered into.)..

Developments in the 2nd Stage Of Decompensated Shock:
In prolonged Shock, the lack of oxygen in the tissues called Hypoxia, makes the blood capillaries more permeable.. This alters the Capillary Exchange and the normal balance between filtration and reabsorption is disrupted.. More components of the blood plasma escape through the filter into Interstitial Fluid and this decreases Blood Volume.. These developments become a progressively deteriorating cycle that further suppresses Cardiac Output and intensifies the oxygen deficiency in the tissue... As Cardiac Output declines further, the circulation becomes more sluggish leading to a decrease in blood velocity, and this opens the door for the development of blood clots and platelet aggregations that develop into obstructions that hinders the cardiac output even further... As the heart pumping continues to become less and less effective changes start to occur that leads to cell destruction.. Metabolism is suppressed and less ATP metabolism occurs, active transport declines, mitochondrial activity declines and lysosomes begin to rupture.. The depressed metabolism leads to excess Lactic and Pyruvic Acids and H+ and Acidosis manifest itself... Acidosis further suppresses the Central Nervous System and the Medulla Oblongata Vasomotor Center.. If at this time the appropriate medical attention is not administered, and the symptoms are misinterpreted then the person goes into the final Irreversible III Stage of Shock, then maintenance will only mask a decline to death ...

(In my opinion, "No known cause, no known cure" only means we need to look a little harder... The developments in the 2nd Stage of Shock parallel the disruptions that would take place if Nutrients were Inhibited.. If Nutrient Inhibitors caused the body to became unable to utilize Iron this would cause an oxygen deficiency.. An oxygen deficiency would cause the Lysosomes to become fragile rupture and burst releasing their nerve cell destroying enzymes.. This would lead to cell destruction.. Without sufficient oxygen in the Cellular Respiration Electron Transport Chain the metabolism of ATP is disrupted and this causes excessive Lactic and Pyruvic Acid and excessive hydrogen which would result in Acidosis... Without sufficient ATPs the Active Transport and Mitochondrial Activity is disrupted... Concerning the Cardiovascular activity, if Calcium is trapped in insoluble salts and cannot be utilized by the cells, the heart muscle cannot perform efficient pumping this suppresses the cardiac activity and enhances an oxygen deficiency)..

Irreversible III Stage of Shock:
In the III Stage of Shock a decline in the Cardiovascular System takes place.. The ATP stores are so depleted that the cells, heart and liver a can no longer function properly... Blood pressure (adequate nutrient-rich blood) cardiac output (heart pumping) and tissue perfusion (disruptions in the filtration reabsorption balance) have declined to the point of being life-threatening... The heart has now deteriorated to the point that it is no longer able to pump adequate (chemical correct, nutrient rich) blood to the cells and death occurs...

(I believe the Nutrient Inhibitors are posing as artificial filters in the vessels altering the concentration of solutes in the different fluid compartments of the body... When sufficient Calcium Ions do not arrive to perform the muscle contractions the heart muscle becomes unable to pump efficiently and this leads to low blood pressure.. This low blood pressure and insoluble Iron complexes and denatured hemoglobin enhances an oxygen deficiency.. The Internal Systems respond to this failure in Capillary Exchange by making the capillaries more permeable... The Internal Systems Capillary Exchange Failure Responses will remain activated until Homeostasis is restored.. Prolonged activation of the Stress/Shock Responses ends up becoming a failure in the Capillary Exchange themselves as they disrupt the Osmotic Pressure.. Disruption in the Osmotic Pressure leads to disruptions in the fluid composition and levels between the different fluid compartments ... The Internal Systems would not recognize chemically altered, ion deficient, nutrient poor blood as blood.. So I believe they would respond as though there was a low blood pressure or a hemorrhaging condition, because not enough Nutrient Rich Blood is available for the cells to function properly. So this would activate the Low Blood Pressure Negative Feedback System and the first stage of Shock which would activate the Renin-Angiotensin Pathway which would stimulate the secretion of Aldosterone... Excessive Aldosterone leads to excessive Sodium.. And Sodium sets the Osmotic Gradient.. As the capillaries become more permeable substances that are normally filtered out, begin escaping into areas where they should not be.. The need to obtain Homeostasis would have profound effects on hormones such as the Parathyroid Hormone (PTH) because it would need to be suppressed to prevent its effects on lowering the blood pressure by functioning as a Vasodilator.. And if PTH is suppressed, then Vitamin D cannot be activated to function as a Vasoconstrictor.. In my opinion, this is how the Homeostasis Imbalance begins to play out.)..

Imbalance in the Capillary Exchange disrupting Body Fluid volume between Compartments:
In a normal situation the smallest blood vessels permits the Capillary Exchange which allows nutrients, vitamins, oxygen, ions and waste material to filter through maintaining a stable balance of the volume of fluid exchange between the plasma fluid in the vessels and the Interstitial Fluid surrounding the cells... The fluid volumes must be kept within strict physiological limits to maintain the balance between reabsorption and filtration.. An imbalance between reabsorption and filtration that lets the Interstitial Fluid become excessive is called Edema.. When Capillary Exchange is functioning properly the larger proteins remains in the blood vessels where they function to maintain the Blood Colloid Osmotic Pressure..

Nephrotic Syndrome: is an imbalance of reabsorption and filtration in the Capillary Exchange that causes Edema... When capillaries become more permeable, the larger plasma proteins such as Albumin are able to escape by passing through the filter.. This causes a Colloid Osmotic Pressure that pulls water out of the blood and into the Interstitial Fluid, increasing the Net Filtration Pressure (NFP)... This means more filtration is taking place and this would create an imbalance between reabsorption and filtration.. As the Albumin concentration in the blood declines this causes the Blood Colloid Osmotic Pressure to decrease.. This lower Blood Colloid Osmotic Pressure causes a decrease in Blood Volume and allows the Interstitial fluid to build up.. Nephrotic Syndrome also causes Hyperlipidemia, which means the blood contains high levels of Triglycericides, cholesterol and phospholipids..

(Lack of oxygen(Hypoxia) causes capillaries to become more permeable.. When the solutes such as glucose become too concentrated in one compartment this causes an osmotic effect that makes the endothelial cells to shrink and they pull apart opening up gaps that let abnormal substances filter through.. Both of these situations could be caused by Nutrient Inhibitors which could create an imbalance in the Capillary Exchange.. If excess Aldosterone causes excess sodium this causes hypertonicity in the ECF, this drains the water out of the cells causing cell dehydration.)..

Altered Fluid Compositions disrupts Cell Communication:
Intracellular Fluid (ICF) is the fluid located inside the cell.. The Extracellular Fluid (ECF) is fluid outside the cell, which is the plasma in the blood vessels and the fluid that surrounds the cells.. The ECF lying between the cells is known as either the Intercellular, Tissue or Interstitial Fluid.... Extracellular Fluid (ECF) and Intracellular Fluid (ICF) have very different chemical compositions that are keep separated by the cell membrane... These fluids hold substances such as nutrients, vitamins, minerals, oxygen, electrically charged Ions such as chloride, calcium, sodium, potassium, hydrogen and phosphate ions and by-products from the internal processes.... For the body to stay in Homeostasis, regulation of the components and the volume of body fluids outside and inside the cells must be maintained within precise limits...

It is crucial for cells to maintain precise limits of the concentration of chemical and the electrical charges in the fluids inside and outside the cells... This difference in the chemical and electrical concentrations across the cell membrane is called Electrochemical Gradient and is essential to Cell Communication... Inside most cells the membrane is more negatively charged than the outside area... When the Negative and Positive Charges are separated they create a potential energy called the Membrane Potential... Any alteration of the balance of chemical levels in the internal fluids can disrupt the ability of cells to communicate across the cell membrane, thus disrupting their physiological functions inhibiting their chemical and electrical processes and inhibit their ability to survive.. Electrolytes function to help in maintaining pH levels, they are essential for maintaining the electric potential of nerve cells that allows messages to be transmitted and they help maintain the proper fluid levels in the body... Any chemical imbalance of Electrolytes or Ions at the cell level, could result in "Cell Communication" failure... Altering the Electrolyte concentration creates a hostile environment that denatures functional proteins..

(So if the Nutrient Inhibitors are filtering out the amount of Calcium Ions available for cell use, this would create a hostile environment that would cause the functional protein hemoglobin to become denatured, this would disrupt the availability of oxygen, and enhance the chemical imbalance at the cell level.. This would activate the Homeostasis Negative Feedback Systems.. It is possible to consume Nutrient Inhibitors in moderation it has been said, but when they saturate the food chain, this poses a threat.. These Inhibitors would have the effect of a poison when saturating every meal, they would be filtering out so much calcium and iron at every meal, robbing the cells of the ability to use this portion of the ingested calcium and iron... If the blocked nutrients have not been supplemented to adjust for the inhibited portion, eventually the body's resources of these nutrients would become depleted at the cell level and alter their chemical composition and disrupt their ability to communicate among themselves.)...

When the "Internal Sensors" responsible for monitoring chemical changes detect silent stressors, such as the "Cell Nutrient Starvation and Altered Chemical Compositions", that are disrupting Homeostasis, impulses are triggered that are sent to the Nervous and Endocrine Systems... These "Internal Systems" starts making adjustments, altering and resetting the internal environment in the "Stress Response" known as the "General Adaptation Syndrome"... This Syndrome remains activated until the internal environment is brought back into Homeostasis... An afflicted person is unaware of these "Silent Internal Responses" and so they go unnoticed.. These automatic precise processes are smoothly carried out through God's Internal Systems He so graciously blessed us with, but that we refuse to pay attention to...

Prolonged activation of the Renin-Angiotensin Pathway:
(Assuming that the Nutrient Inhibitors altered the chemical compositions and activated a "Deficient Cell Nutrient Stress Response" which activated the Shock Response for a prolonged period of time, it is reasonable to assume that this could lead to excessive secretion of Aldosterone and Antidiuretic Hormone (ADH) and it is quite possible that the General Adaptation Syndrome would reset the Threshold level that controls Atrial Natriutetic Peptide (ANP)... Aldsosterone, ADH and ANP are the regulators of the blood levels of sodium {Na+})...

ADH is the hormone that regulates kidney functions and when it is present a lot of water is reabsorbed and goes back into the blood, resulting in concentrated urine.. When ADH is missing urine is diluted containing a large volume of water... Diluted Urine is produced by the kidneys, only when the blood has more solutes in a given volume than does the urine... High Blood Pressure stimulates less reabsorption, allowing more water and salt to be removed, this increases urine volume..

(So if the General Adaptation Syndrome Stress Response has been activated and the Blood Pressure threshold has been raised then the seemingly high blood pressure would be hindered from suppressing reabsorption, this would disrupt the control over urine volume. So a disruption in Reabsorption and Urine Volume could begin to manifest at this point.)...

ANP is released by the atria of the heart and functions as a vasodilator to lower blood pressure and stimulates urine removal of salt and water in order to reduce Blood Volume...
(So if the chemically altered "Low, nutritionally deficient Blood" does not deliver sufficient calcium ions, this which would result in insufficient pumping by the heart muscle causing a Low Blood Pressure.. The response would be to deliver more "High Grade Nutrient Rich Blood" to the cells... The General Adaptation Syndrome Stress Response would be activated to reset the High Blood Pressure Threshold... To prevent the "Fight or Flight Stress Response" from being disrupted the normal threshold for the secretion of ANP, in my opinion could possibly be reset by the General Adaptation Syndrome in order that it's role in reducing blood volume is limited until Homeostasis is achieved and Aldosterone and ADH have accomplished their goal... This would allow Blood Pressure restraints to be removed and interfere with the Blood Volume regulation.)...

Aldosterone is the mineralocorticoids most responsible for maintaining Homeostasis in Electrolyte and water concentrations... Blood levels of K+ and the Renin-Angiotensin Pathway work in sync to regulate the secretion of Aldosterone.. The Renin-Angiotensin Pathway and thus Aldosterone secretion, is activated by conditions that cause a decrease in blood volume that leads to a falling blood pressure, such as decreased Cardiac Output, dehydration, hemorrhaging or in the Shock response when cells are not receiving sufficient nutrients to perform their chemical functions...

(So assuming that the Shock Response to deficient Ions at the cell level is activated and the situation cannot be rectified, this would leave the Renin-Angiotensin Pathway Turned-On and could lead to excessive Aldosterone.)...

Aldosterone has a profound affect on the Urinary System... Aldosterone causes the kidneys to retain water, increases their reabsorption of Na+, HCO3- and Cl-and stimulates them to excrete more K+ through the urine.. Aldosterone's effect on the kidneys is to set the Osmotic Gradient causing water to be pulled from the filtrate and put back in the blood.. Aldosterone also helps maintain pH homeostasis by increasing H+ excretion in order to prevent Acidosis.. Excessive secretion of Aldosterone causes excessive retention of water and Na+ which leads to high blood pressure (hypertension) and depletes the blood levels of potassium (K+).. If the K+ deficiency is excessive then the muscles fibers and neurons are desensitized and their electrical properties are disrupted..

(In my opinion the excessive secretion of Aldosterone could have a disruptive effect on the potassium (K+) blood levels which could disable the ON-OFF Switch Mechanism that regulates Aldosterone Secretion.. The On-Off Aldosterone Secretion Switch Mechanism is the blood levels of K+ and the Renin-Angiotensin Pathway working in sync)..

The Urinary System's primary purpose is to regulate blood pressure, composition and volume..

Effectors on Urine and Blood Volumes:
#Urine Volume is affected by Blood Osmotic Pressure, Blood Pressure and Diuretics..
#A Low Blood Colloid Osmotic Pressure decreases the Blood Volume and restricts the secretion of ADH (Antidiuretic Hormone) and increases the urine volume.. Decreased Albumin concentrations in the blood, causes a lower Blood Colloid Osmotic Pressure and this moves water out of the blood and into the Interstitial Fluid..
#High Blood Osmotic Pressure stimulates ADH secretion this causes urine volumes to decline..
#Low Blood Pressure activates the Renin-Angiotensin Negative Feedback System this triggers the reabsorption of water and sodium, and this decreases the urine volume output..

(So if the Inhibited Nutrients become a Stressor that is perceived to be a low blood pressure the Renin-Angiotensin Pathway is activated this increases the Blood Pressure... If the Blood Pressure Threshold is reset by the General Adaptation Syndrome then this leads to a disruption in the Capillary Exchange and larger substances such as Albumin and other usually filtered substances are forced through the filter into the Interstitial Fluid.. As these larger substances are moved out of the blood the Blood Colloid Pressure drops and this makes water move out of the blood into the Interstitial Fluid.. This leads to hyper tonicity of the ECF and causes cellular dehydration.. This goes on to many disruptions but the reason I mention it is because I believe the Insoluble calcium Salts are passing through the filter and moving into the Interstitial Fluids and there they cannot be utilized by the Cells... There they are trapped in a "Fight or Flight" Stress Response the Calcium levels are rising in the Interstitial Fluid and becoming excessive but the Cell are calcium starved because they can not pick it up and use it.. So what does the "Internal Systems" do with it, the Cells are going to die without Calcium but the Interstitial Fluid is becoming saturated with calcium.. Which is the Basis of my theory that the PTH/ Calcitionin Calcium Phosphate Negative Feedback Regulating System is the initial system that has been thrown out of Homeostasis and is the root cause of Auto-Immune Disease.)..

Inhibited Kidney Functions:
Kidneys regulate the composition of the internal environment including the Interstitial Fluid, by adjusting the volume and composition of the blood and removing waste products.. Kidney regulation of blood composition and volume starts with Glomerular Filtration.. Kidneys regulate Blood Pressure and Blood Volume.. Kidneys excrete different amounts of H+ in order to maintain pH.. Kidneys respond to the need for oxygen by secreting Erythropoietin which activates the Red Blood Cell Formation System...

(So if the Aldosterone is stimulating excessive reabsorption of Na+ by the kidneys' collecting ducts and convoluted tubules and disrupting the normal Osmotic Gradient and raising Blood Pressure this would have a profound effect on the Kidneys ability to maintain the Interstitial Fluid and internal environment.. And when vasoconstriction is targeted to the abdominal area for a prolonged period of time it just stands to reason the kidneys would finally sense the oxygen deficiency, in which case they would activate the RBC Formation System.)..

Disruption Of the Osmotic Pressure and Positive and Negative Ions between Compartments:
Normally, Sodium is the most prevailing positive ion in the ECF... Chloride is the prevailing negative ion in the ECF...Potassium (K+) is the prevailing positive charge inside the Cell and helps maintain the fluid volume... If K+ moves out of the cell H+ moves into the cell to keep the pH balanced....

(In the Nutrient Inhibitor induced Stress Response Aldosterone would become excessive causing a deficiency in K+ and an excess of water and Sodium and an excess of H+ due to the disrupted ATP metabolism. The Chloride would follow the sodium due to an electrical attraction. It just stands to reason this would start disrupting communication.)...

Sodium and water:
Aldosterone controls the level of sodium (Na+) in the blood.. Sodium plays a major role in fluid and electrolyte balance due to its osmolarity influence in the ECF... Na+ has a major influence on the nerve and muscle impulses... As sodium is filtered back into the blood it sets the Osmotic Gradient, which pulls the water from the filter back into the blood with it..

(In my opinion, as long as the blood is deficient and the cardiac output is deficient this would keep the Aldosterone secretion activated, which could lead to Hypernatremia which is excessive sodium in the blood.)...

Excessive sodium in the ECF disrupts the osmotic pressure causing Hypertonicity, which is a higher osmotic pressure in the ECF... This higher Osmotic Pressure draws water out of the cells and pulls it into the ECF and this leads to dehydration in the cells... This leads to hypertension..

Chloride:
The concentration of Chloride (Cl-) in the blood and cells, could be indirectly disrupted by excessive Aldosterone, reason being Cl- is electrically attracted to Na+ and readily follows the sodium... Excessive Aldosterone secretion, Acidosis (high concentration of H+ in the blood) or dehydration can lead to elevated concentration of Chloride in the blood.. Cl- balances the level of negative ions between the ECF and inside the cells.. A Chloride shift takes place between cells and plasma to regulate levels of carbon dioxide, Cl- and HCO3- are exchanged to maintain a correct balance of negative charges in the ECF and the ICF..

(I believe the Nutrient Inhibitors are limiting the amount of oxygen that makes it to the cells, which is crucial for activating the exchange that lets carbon dioxide leave the cells and enter the interstitial fluid so it can travel through the blood and be expelled. If this is the case the "Internal Tissue Respiration" process could be disrupted.. This could have an effect on the Carbon dioxide levels.)..

Bicarbonate:
HCO3- is the second main negative ion in the ECF.. Bicarbonate is a main buffer of H+ in plasma...(This buffer could be depleted due to the Nutrient Inhibitors disrupting metabolism and creating excessive H+)...

Potassium (K+):
Aldosterone stimulates the lose of K+ through urine lowering its level of concentration in the plasma.. Excessive sodium causes low levels of K+... If K+ moves out of the cell H+ moves into the cell to keep the pH balanced....
(I believe the Nutrient Inhibitors could have caused the potassium to be exchanged for Hydrogen in the cells.. Reason being the excessive Aldosterone would deplete the potassium resources while the disruption in ATP metabolism would create excessive Hydrogen... So if access to sufficient potassium has been disrupted then it would be reasonable to assume that the "Internal Systems" could do what they are already geared to do and pick up the alternative H+ which would help eliminate some of the excess Hydrogen.)..

My Opinion of the Initial Root Cause of Auto-Immune Disease:
(In my opinion, all of these pieces of the puzzle pull together to bring about the whole picture of the total destruction of the Homeostasis Balance which is the initial step into the malfunction called Autoimmune Disease.. The previous information maps out how I come to the point of believing that excessive consumption of Nutrient Inhibitors could be the root cause of all Autoimmune Disease.. In my opinion the imbalance between Calcium and Phosphates created by the Oxalic and Phytic Acids and the disruption it has caused in the PTH/ Calcitonin Negative Feedback Loop is the culprit behind Auto-immune disease...

(I believe the Nutrient Inhibitors are filtering out the cells' access to Calcium and other nutrients, this causes "Cell Nutrient Starvation" which becomes the "Internal Stressor" that activates the Negative Feedback Systems and the General Adaptation Syndrome, this leads to long-term secretion of Aldosterone, as this secretion becomes excessive it disrupts the Osmotic and Blood Pressures and in turn this creates an imbalance in Capillary Exchange.. This imbalance alters the chemical and fluid concentrations in the different compartments, which allows substances to be filtered into compartments where they should not normally be found... This disables the cells normal communication tools.. I believe this has allowed the Insoluble Calcium Salts and Insoluble Iron Complexes to be pulled into the Interstitial Fluid where they cannot be utilized by the Cells.. Here they block the "Nutrient Delivery Pathway" and this is causing confused messages among the "Internal Systems"... These confused messages are disrupting the PTH/Calcitonin Negative Feedback System which regulates Calcium, Phosphates and Magnesium.)..

There are several different Research views on how the Calcitonin/ PTH Feedback Regulation operates, so I am including information from three views so a person can use their own judgement on what is taking place.. All three may be at work or some of the information may be out dated, but it is the information that I am working from..

This information about the Calcium levels in the Interstitial Fluid is the most recent information:
As long as Calcium levels in the ECF remain in high or normal range, PTH secretion is inhibited..
(This would mean, normal or high levels of Calcium in the blood or the Interstitial Fluid is the PTH OFF-Switch.. On the other hand, this also means that low levels of Calcium in the blood or the Interstitial Fluid is the PTH ON-Switch... So as long as the Calcium Levels remain normal or high in the blood or Interstitial Fluid the PTH secretion will remain turned-OFF.. If the Nutrient Inhibitors are binding the Calcium in insoluble salts the cells cannot pick the Calcium up, so it just stands to reason, the calcium will remain at normal or higher levels in the blood and Interstitial Fluid, because the cells cannot pull it out to utilize it.. This situation would disable the PTH ON-OFF Switch by locking it in the OFF-Position)...

ON-OFF Switches:
PTH serve as the ON-OFF-Switch for Osteoclast (Bone-destruction and reabsorption).. Calcitonin also serves as the OFF-Switch for Osteoclast.. When PTH is turned OFF this inhibits Osteoclast activity, which serves to bring down the Calcium Levels in the blood and Interstitial... When PTH is turned ON this enhances the Osteoclast activity which increases the amount of bone reabsorbed and puts more Calcium in the blood and Interstitial Fluid... In this position PTH serves as the speed regulator of the continuous exchange of Calcium between the blood and the bones.. (So if the Nutrient Inhibitors have the PTH secretion locked down, the calcium exchange between the blood and bones is disrupted and the Osteoclast activity is locked down... This would disrupt the Bone Formation Process by creating an imbalance in the Osteoclast and Osteoblast.)..

PTH serves as the ON-Switch to activate Vitamin D to 1'25-dihydroxycholeacalciferol.. This active form of Vitamin D is an essential cofactor in Switching-ON the small intestines Calcium absorption ability.. (So if the Nutrient Inhibitors have the PTH locked down the activation of Vitamin D is inhibited, and Calcium absorption from the small intestine is inhibited.)...

PTH serves as the ON-OFF-Switch for Kidneys Renal Tubules reabsorption of Calcium and Phosphates.. When PTH is turned ON, it turns OFF the Active Transport of the phosphate ion(PO42-), as a result the reabsorption of (PO42-)decreases, while at the same time Calcium reabsorption is increasing... This ensures the ECF Calcium/Phosphate concentrations stay constant and inhibits Calcium /Phosphate Salts from being deposited in soft body tissue and the bones.. When PTH is turned OFF, phosphate reabsorption is regulated by the Overflow Mechanism, Transport Maximum, this means only the excessive amounts of phosphates are being removed ...(So if the Nutrient Inhibitors have locked the PTH Secretion in the OFF position, then the Active Transport of Phosphates is locked in the ON position.. The reabsorption of phosphates would become excessive and Calcium reabsorption would decline.. When the phosphates become excessive the major complication is the precipitation (rapid depositing) of calcium phosphate salts in the bones, arteries, joints and soft tissues... A problem is the calcium would be bound up in insoluble calcium salts so I wonder how this would alter the excessive phosphate mineral salts being deposited in the bones and the arteries, tissue and joints.. Another problem that I see could arise with the Nutrient Inhibitors is a disruption in the phosphate Ion balance.. In a normal body pH the HPO42- is the most prevalent phosphate Ion.. The Nutrient Inhibitors would disrupt the metabolism of ATP which would alter the normal body pH causing Acidosis, so what kind of disruptive effect would this have in the concentrations of the different phosphate ions. A disruption in the concentrations of HPO42- could lead to disruptive effects on the Phosphate Buffer Systems.)..

PTH and Calcitonin are the regulators of blood plasma levels of HPO42-.. PTH turns ON the Osteoclast activity to release phosphates from the bone matrix mineral salts so phosphate Ions can be excreted...

(So if the Nutrient Inhibitors have locked the PTH in the OFF position and the Phosphates are not being targeted for excretion, then the Calcitonin would be burdened with lowering the blood levels of the excessive phosphates.. So the Osteoblast would be Switched On and the precipitation of the phosphate salts in the bones would be activated.. The bones would become saturated with mineral salts, but what chemical composition.)..

PTH Functions ...
PTH activates synthesise of hormone Calcitriol aka 1,25-dihydroxycholecalciferol or 1'25-dihydroxy vitamin D3 from Vitamin D.. Calcitriol increases the absorption of Ca2+, Mg2+ and HPO42- during digestion. And Calcitriol serves as a Vasoconstrictor that increases the blood pressure...

(In my opinion the Negative Feedback Loop is disabled by the inability of the cells to pick-up the calcium and use it, so the PTH secretion is never turned ON.)...

PTH Dysfunctions:
When PTH is inhibited the breaking down of the bone "Osteoclast Reabsorption Activity" is inhibited thus disrupting the constant exchange of calcium between blood and bone.... Bone Formation is carried out by Osteoclast and Osteoblast... In the Bone Formation Process a very delicate balance between Osteoclast (destroying) and Osteoblast (forming) has to be maintained... Most Bone Diseases are caused by an imbalance between the two..

Inhibited PTH causes less Calcium to be absorbed and at the same time, less Phosphates are excreted in the urine.. As a result of Inhibited PTH Secretion, Calcium declines and Phosphates accumulate in the body.. When one goes down the other goes up..

If Calcium in the blood and Interstitial Fluid decreases this leads to muscle disruptions such as deficiency in respiration and heart pump muscle contractions, spasms, tetany, twitching and also spontaneous discharges from the neuromuscular system from overly excited nerve fibers..

(With the Nutrient Inhibitors these symptoms could arise due to the fact the calcium would remain normal or high and not decrease, it may be there but it is bound in insoluble calcium salts and would not be available for the cells to use so it would be as though the calcium were deficient... I believe, the Insoluble Calcium Salts get pulled into the Interstitial Fluid because the cells are starving for Calcium and are trapped in a 'Fight or Flight" Stress Response because the cells are unable to utilize the Calcium once it gets there, so the need for the Calcium remains.. It is reasonable to assume the Insoluble Calcium Salts would stay available in the Interstitial Fluid and the blood awaiting transportation into the Cells.. It is reasonable to assume that the ECF could become saturated with these Calcium Salts and so the Interstitial Fluid levels of Calcium would remain at least normal and probably high all the time.. I assume this would mean since the Calcium levels are normal or high, the "Internal Systems" would not be stimulated to Switch-ON the PTH, because the Calcium levels in the ECF never drops.)..

Calcitonin:
High plasma levels of Calcium serves as the ON-Switch for the secretion of Calcitonin... When blood Calcium levels rise Calcitonin secretion is Switched-ON..
Calcitonin serves as the ON-Switch of Osteoblasts and the OFF-Switch of Osteoclast...
Calcitonin causes the Osteoblast to lower plasma levels of Calcium ions by depositing them as calcium mineral salts in the bone matrix..Osteoblast deposits phosphate ions in the bone matrix when they become to high also..

(Since cells are unable to utilize the available calcium because it is bound up in the insoluble calcium salts, it just stands to reason that the Calcium levels remain normal or high because it cannot be utilized... So the PTH would stay turned OFF and the phosphates would rise and Calcitonin would be turned-ON and the normal continuous bone and blood calcium exchange might not be taking place.)...

#2. This information is a little older:
The Calcium levels in the blood and Interstitial Fluid is the Trigger Mechanism for regulating PTH Secretion.. If the level of Calcium rises in the Interstitial Fluid it causes the Parathyroid Glands to lower their output of PTH.. One way this rise can take place is, if the bones become saturated with calcium salts this causes the Interstitial Fluid Calcium level to rise.. Parathyroid secretion is triggered when the calcium levels in the Interstitial Fluid and blood drop even a small amount.. When the PTH is inhibited the Osteoclast remain inactive..

(So if the Nutrient Inhibitors cause the Calcium levels to remain normal or high because the calcium in the plasma cannot be utilized by the cells and this in turn shuts the PTH secretion down then the phosphates could become excessive and this could lead to precipitation of mineral salts into the bones and if the bones are saturated with mineral salts this could help disrupt the Interstitial Fluid further creating a perpetual disruption.. Because if calcium salts saturate the bones this makes the calcium level in the Interstitial Fluid rise and this inhibits the secretion of PTH.)..

#3. This information is the Oldest:
The PTH stimulates bone reabsorption of calcium, by stimulating the enzyme adenyl cyclase to make cyclic-AMP using ATP... This disrupts the active transport of the calcium ions out of the cells chemical compounds (cytoplasm) into the organelles (Nucleus, Ribosomes, Endoplasmic Reticulum, Golgi Complex, Lysosomes, Peroxisomes, Mitochondria, Cytoskeleton, Flagella and Cilia, Centrosome and Centrioles.).. This makes the cell reabsorb surrounding matrix bone tissue.. The PTH may increase Calcium Ion solubility by freeing bone citrate, which decreases the bone pH.. This makes the PTH the first messenger in releasing Calcium ions from the bones and the second messenger is cyclic-AMP... Calcium blood levels are the trigger mechanism for Calcitonin secretion they rise proportionally at the same ratio... Calcitonin works by activating the active pumping of Calcium Ions into the extracellular areas from the bone cells.. When the Calcium Ions is pumped out of the cells chemical compounds (cytoplasm), this cancels the PTH message to release Calcium ions from the bone and inhibits the reabsorption...

(It seems in this older theory, the effect the PTH has is to disrupt the ATP driven Active Transport of Calcium into the nucleus, ribosomes, endoplasmic reticulum, golgi complex, lysosomes, peroxisomes, mitochondria, cytoskeleton, flagella and cilia, and Centrosome and centrioles... If this is the case the Nutrient Inhibitors could mimic the PTH effects and accomplish the same thing the PTH sets out to accomplish without the activation of the PTH, which means the internal Systems would not be stimulating the secretion of PTH.. In a sense the PTH could remain turned-OFF, because the Nutrient Inhibitors have filled its shoes... If the Nutrient Inhibitors make the Iron Insoluble this causing insufficient oxygen in the Cellular Respiration Electron Transport Chain and thus causing an ATP deficiency.. An ATP deficiency would disrupt the Active Transport System, so why would PTH need to be activated to do the job that the ATP deficiency is doing.. The calcium would remain in the cytoplasm and this would force the bone reabsorption of surrounding matrix bone tissue.. Although the PTH would not be available to increase the Calcium Ion solubility by freeing bone citrate, the body's overall pH would be lowered due to the fact that the lack of oxygen in the Cellular Respiration Chain leads to excessive H+ which causes Acidosis which causes a lower pH... Then the high amounts of trapped insoluble Calcium in the plasma or Interstitial Fluid would Trigger the Calcitonin and it would pump the calcium out of the cells and it could all be done without the assistant of PTH.. But what unknown PTH functions have be bypassed by this type of disruption.)..

Nutrient Inhibitors Oxalic and Phytic Acids...
#Oxalaic and Phytic Acid disrupt Calcium absorption by creating Insoluble Calcium Salts..
#Phytates and Oxalates make insoluble Iron complexes..
#Inositol in plants is Phytic Acid, which is an organic acid that interferes with Calcium and Iron absorption, because it binds to them and creates insoluble complexes.. But in animal tissue Inositol is a component of the fatty acids, nitrogenous bases, substances with phosphorus as a component and phospholipids..


Magnesium:
Magnesium is the second most prevalent Intracellular positive charged ion.. Decreased PTH and extracellular fluid volume and acidosis all increase renal excretion of Mg2+..(If I am right the Nutrient Inhibitors could cause all three of these circumstances, if that is the case Mg2+ could be deficient)..

Phosphates:
Phosphates are very important negative charged ions inside the cell..
There are three phosphate ions (H2PO4-, HPO42- and PO43-).. HPO42- is the prevailing ion in normal pH..(With Nutrient Inhibitors the pH would not be normal it would be very acidic).. They all three are important in the Phosphate Buffer System.. PTH and Calcitonin are the regulators of the plasma levels of HPO42-... PTH activates the Osteoclasts to stimulate the bone matrix to release of Phosphate from the mineral salts, making the renal tubular cells excrete phosphate Ions.. Blood phosphate levels are lowered when Calcitonin activates osteoblast and inhibits the Osteoclasts.. Calcitonin causes the Osteoblasts to take phosphate ions out of the blood and deposit them in the bone matrix, there they join the calcium ions and make bone matrix mineral salts... Hyperphosphatemia, excessive phosphate levels, occur if the kidneys do not remove excess phosphates. This condition can also be caused by cell destruction which puts phosphates in the blood or increased intake of phosphates... The major problem that arises from excessive phosphates is precipitation of calcium phosphate in the soft tissues, arteries and joints...

(I believe the Calcium would remain in the normal to high range in the ECF, the cells are just unable to utilize the Insoluble Calcium Salts... If the levels of Calcium remain in the normal or high range in the ECF this causes PTH secretion to be inhibited.. So I believe the PTH secretion would remain inhibited or nullified.. I believe the increased permeability of the capillaries and higher blood pressure in response to Nutrient Starvation, would allow the Insoluble Calcium Salts to be pushed past the filter and enter into the Interstitial Fluid and there they would cause the increase in the Interstitial Fluid Levels of Calcium that inhibits secretion of the PTH.. This circumstance would cause the Phosphates to build up because the PTH would be inhibited and not present to stimulate the excretion of Phosphates... This would cause the precipitation of Calcium/Phosphate salts into the bones soft tissue, joints and arteries.. As the Phosphate levels rise Calcium levels begin to fall.. The excessive phosphates would enhance the Oxygen disruption by increasing Insoluble Iron Complexes, because excess Phosphates hinder Iron absorption, but if sufficient Calcium is available it will bind with the Phosphates and free the Iron for use.)..

Calcium is a positive charged ion in the ECF... Free unattached Ca2+ in the plasma is equivalent to the amount attached to proteins in the plasma..

(I believe the Homeostasis mechansim is disrupted by insoluble calcium salts causing "Cell Nutrient Starvation" resulting in a "Fight or Flight Stress Response" that disrupts the Capillary Exchange and ends up disabling the PTH/ Calcitionin Negative Feedback Calcium/Phosphate Regulating Systems..
Inhibiting the Parathyroid Hormone (PTH), disrupts the activation of Vitamin D, Calcium and Magnesium absorption, phosphate excretion, osmotic pressure, the osteoclast and osteoblast balance disrupting bone formation, etc. and leads to the "Stress Response" from the "Internal Systems" that ends up in Auto-Immune disease situations).. Deficient Calcium could disrupt membrane permeability allowing the un-useable calcium to get trapped inside cells causing an overload..



July 07/2009

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