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Autism Centers of Excellence (R01).

Autism spectrum disorders (ASD ASD
atrial septal defect

ASD Atrial septal defect, see there
) are complex neurodevelopmental disorders with early childhood onset. ASD prevalence may be increasing, and ASD is more common than previously thought. These disorders, for which there is presently no cure and only limited treatments, generally have lifelong effects.

The NIH "Not invented here." See digispeak.

NIH - The United States National Institutes of Health.
 currently supports a vast array of projects in autism research. Centers such as the STAART STAART Studies to Advance Autism Research and Treatment  (Studies to Advance Autism Research and Treatment) and CPEA CPEA Certified Professional Environmental Auditor (BEAC)
CPEA Collaborative Programs of Excellence in Autism
CPEA Certificate of Practice in Estate Agency
CPEA Child Protection Education of America, Inc.
 (Collaborative Programs of Excellence in Autism) programs support some of these investigations. The CPEA program, an international program begun in 1997, now includes nine centers. These Centers focus research on the possible causes of autism Autism and autism spectrum disorders are complex neurodevelopmental disorders. Many causes of autism have been proposed, but its theory of causation is still incomplete.[] , including genetic, immunological, and environmental factors. The CPEA program resulted from a congressionally mandated conference on the State of the Science in Autism. The attendees identified gaps in the knowledge of autism and directions for future research. Both NICHD NICHD National Institute of Child Health and Human Development.  and NIDCD NIDCD National Institute on Deafness & other Communication Disorders  sponsor the current CPEA program. As a result of the efforts of researchers affiliated with the CPEA, data now exist on the genetics and outward characteristics of the largest group of well-diagnosed persons with autism in the world. After the establishment of the CPEA Centers program, Congress enacted the Children's Health Act The Children's Health Act of 2000 (Public Law 106-310 Sec. 1004) is a legislative measure, passed by the United States Congress which directs federal agencies to undertake a national, long-term study of children's health and development in relation to environmental exposures,  of 2000. This legislation mandated the establishment of a new autism research program. In response, the five Institutes of the NIH Autism Coordinating Committee (NIH-ACC; represented by NICHD, NIDCD, NIEHS NIEHS National Institute of Environmental Health Sciences (NIH, DHHS) , NIMH, and NINDS NINDS Neurology A multicenter, double blinded, randomized trial–National Institute of Neurological Disorders and Stroke which evaluated the effects of tPA therapy in Pts with stroke. See Thrombolytic therapy, tPA. ) implemented the STAART program. Each of the eight currently funded STAART Centers contributes to the autism research base in the areas of causes, diagnosis, early detection, prevention, and treatment. Collaborations among the STAART centers include a multisite psychopharmacological psy·cho·phar·ma·col·o·gy  
The branch of pharmacology that deals with the study of the actions, effects, and development of psychoactive drugs.

 clinical trial. The CPEA and the STAART programs interact extensively through a shared data coordination center.

Consolidation of funding from the CPEA and STAART programs is now needed to maximize coordination and cohesion of NIH-sponsored efforts in autism research. The new autism centers and networks will be called the Autism Centers of Excellence or ACE.

The focus of the ACE must be on the causes and best treatment of autism (as listed in the autism research matrix hrtp:// In February 2003, Congress requested that the Department of Health and Human Services Noun 1. Department of Health and Human Services - the United States federal department that administers all federal programs dealing with health and welfare; created in 1979
Health and Human Services, HHS
 (DHHS DHHS Department of Health & Human Services (US government)
DHHS Dana Hills High School (Dana Point, California)
DHHS Deaf and Hard of Hearing Services
DHHS Deaf and Hard of Hearing Services
) develop a set of autism research goals and activities for the next several years (House Report 10910). Input into this activity included a meeting of autism investigators with a range of scientific expertise as well as input from community members. Preparation for specifying this matrix involved a two-day meeting of an expert panel of scientists; public presentation and discussion of a draft matrix at the Autism Summit Conference in Washington DC on 20 November 2003; and adoption of the matrix by the Federal Interagency Autism Coordinating Committee (IACC IACC International Association of Conference Centers
IACC Interagency Autism Coordinating Committee (DHSS)
IACC International Anti-Corruption Conference
IACC International AntiCounterfeiting Coalition

Research projects should focus on finding causes and preventive intervention for autism as well as improved treatment. Applications should incorporate the latest techniques and propose studies to advance key goals related to causes and best treatment on the autism research matrix. Examples include, but are not limited to 1) identification of individual characteristics that predict response to behavioral, pharmacologic, and other treatments; 2) identification of environmental factors (e.g., viruses, medication, lifestyle factors, environmental chemicals) that contribute to the development of autism and their associated developmental windows; 3) identification of the biologic and/or behavioral markers to develop indices of risk for the development of autism in infants; 4) intervention methods for infants and toddlers developed to lower the age for which there are efficacious interventions; 5) multisite randomized clinical trials to identify moderators and effective ingredients (e.g., dose, intensity, mode of delivery, age of onset The age of onset is a medical term referring to the age at which an individual acquires, develops, or first experiences a condition or symptoms of a disease or disorder.

Diseases are often categorized by their ages of onset as congenital, infantile, juvenile, or adult.
) of early intervention treatments; 6) multisite longitudinal study of subsequent pregnancies and infant siblings of children with autism to identify risk factors, broader phenotype, and early characterization of autism; 7) innovative and newly developed intervention strategies to improve outcomes in school and community settings throughout the lifespan (e.g., academic functioning, social and adaptive behavior, family functioning, employment), including transitions; 8) development of efficacious drug treatments that target core symptoms of autism; 9) characterization of the neuropathology neuropathology /neu·ro·pa·thol·o·gy/ (-pah-thol´ah-je) pathology of diseases of the nervous system.

The study of diseases of the nervous system.
 of autism to identify impaired brain structures and functions; 10) identification of susceptibility genes and animal models of autism for further study of phenotypic characteristics of autism.

NIH will consider centers as well as networks in response to the ACE initiative. This funding opportunity solicits applications for ACE Networks supported by the R01 mechanism. A companion RFA RFA right frontoanterior (position of the fetus).
Radiofrequency ablation (RFA)
A procedure in which radiofrequency waves are used to destroy blood vessels and tissues.

Mentioned in: Prenatal Surgery
 (RFA-HD-06-016) solicits applications for ACE Centers supported by the P50 mechanism.

This funding opportunity solicits applications for ACE Networks. A network will consist of multiple sites focusing on a specific topic of research for R01 support through this funding opportunity. Each network will submit one R01 application that includes subcontracts to the collaborating sites. An ACE Network application must include one or more collaborative projects that require multiple sites for optimal design and conduct of studies. For example, an interrelated in·ter·re·late  
tr. & intr.v. in·ter·re·lat·ed, in·ter·re·lat·ing, in·ter·re·lates
To place in or come into mutual relationship.

 series of clinical trials of pharmacologic, behavioral interventions, or a combination of these, could be an example of the focus of such a network. Other examples include, but are not limited to, a multisite network that could conduct one or more neuroimaging protocols and collect data using common standards and a multisite epidemiology study of risk factors (e.g., genetic, environmental) for ASD. Special populations requiring large numbers of participants for each protocol may also be studied best under a network because of enhanced recruitment and other benefits of multisite subject accrual.

A companion RFA solicits applications for ACE Centers (RFA-HD-06-016). Centers bring together expertise, infrastructure, and resources focused on major questions about autism. Centers should involve collaborations of basic and clinical scientists optimally suited to address the research questions posed. NIH expects Centers to provide an environment and core resources to bring together biomedical, behavioral, and clinical science investigators to study autism. Collaborations involving more than one institution are strongly encouraged to provide optimal resources and expertise. The centers should provide investigators with well-characterized patients and control subjects, family information, and other scientific resources that facilitate research projects. Applications for centers must include a minimum of three but no more than six research projects. The addition of core support is optional and will depend on specific needs.

An ACE Center must support major multidisciplinary research programs, consisting of interdependent and interrelated subprojects. Meaningful and committed interactions among the disciplines must be evident. Subprojects may share materials, results, data, patient populations, or methodologies. Results of one subproject may well affect the understanding and interpretation of data from another project and thereby influence the nature of the research performed in one or more of the other subprojects. In addition, each subproject must have goals and objectives that focus on the common unifying theme that interrelates the subprojects.

NIH is developing a National Database for Autism Research (NDAR NDAR Next Descriptor Address Register
NDAR National Database of Ageing Research (Centre for Policy on Ageing, UK)
NDAR Nondestructive Assay Review
) to facilitate data sharing. NDAR ( is both a database and a set of tools for autism researchers--a national resource for collaboration in autism research and clinical practice.

All ACE Centers and Networks will be required to contribute data to NDAR. Data sharing is required and NDAR will be involved to facilitate sharing activities. NDAR will function as a data repository for all ACE projects. Central clinical coordination and local data management for data cleaning and entry and biostatistical consulting will be the responsibility of the ACE Center or Network. Depending on the number and size of the multsite projects, NDAR may provide Data Coordinating Center (DCC (1) (Direct Cable Connection) A Windows 95/98 feature that allows PCs to be cabled together for data transfer. DCC actually sets up a network connection between the two machines. ) functions for large ACE multisite projects to increase efficiencies. This funding opportunity will use the Traditional Research Project Grant (R01) award mechanism. As an applicant, you will be solely responsible for planning, directing, and executing the proposed project.

This funding opportunity uses just-in-time concepts. It also uses the modular as well as the nonmodular budget formats (see funding/modular/modular.htm). Specifically, if you are submitting an application with direct costs in each year of $250,000 or less, use the modular budget format described in the PHS (Personal Handyphone System) A TDMA-based cellular phone system introduced in Japan in mid-1995. Operating in the 1880-1930 MHz band, PHS uses microcells that cover an area only 100 to 500 meters in diameter, resulting in lower equipment costs but requiring more base  398 application instructions. Otherwise follow the instructions for nonmodular research grant applications.

The PHS 398 application instructions are available at phs398.html in an interactive format. Applicants must use the currently approved version of the PHS 398. For further assistance contact GrantsInfo, 301-435-0714 (telecommunications for the hearing impaired: TTY (TeleTYpewriter) See teletypewriter and TDD/TTY.

(hardware) tty - /tit'ee/ (ITS pronunciation, but some Unix people say it this way as well; this pronunciation is not considered to have sexual undertones), /T T Y/

1. teletypewriter.

 301-451-0088) or by e-mail:

Applications must be prepared using the most current PHS 398 research grant application instructions and forms. Applications must have a D&B Data Universal Numbering System The Data Universal Numbering System, abbreviated as DUNS or D-U-N-S is a system developed and regulated by Dun & Bradstreet (D&B) which assigns a unique numeric identifier to a single business entity. This numeric identifier is then referred to as a DUNS number.  (DUNS) number as the universal identifier when applying for Federal grants or cooperative agreements. The D&B number can be obtained by calling 866-705-5711 or through the web site at The D&B number should be entered on line 11 of the face page of the PHS 398 form.

The letter of intent receipt date for this RFA is July 11, 2006, with the application receipt date August 11, 2006. The complete version of the RFA is available at

Contact: Alice Kau, Mental Retardation and Developmental Disabilities Branch, Center for Developmental Biology and Perinatal Medicine, National Institute of Child Health and Human Development, 6100 Executive Boulevard, Room 4B09F, MSC (1) (MSC.Software Corporation, Santa Ana, CA, Founded in 1963 by Richard H. MacNeal and Robert G. Schwendler, MSC is the world's largest provider of mechanical computer aided engineering (MCAE) strategies, simulation software and services.  7510, Bethesda, MD 20892-7510 USA, Rockville, MD 20852 USA (for express/courier service; non-USPS service), 301-496-1383, fax: 301-496-3791, e-mail: Reference RFA-HD-06-004
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Title Annotation:Announcements: Fellowships, Grants, & Awards
Publication:Environmental Health Perspectives
Date:May 1, 2006
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