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Attack of the clones: as cloning technology marches forward, state legislatures are faced with some hard decisions.

First, it was sheep. Then, it was "CC," the cloned house cat. If a cloned sheep spawned CC's creator Genetic Savings and Clone, where pet owners can bank Fido's DNA DNA: see nucleic acid.
 or deoxyribonucleic acid

One of two types of nucleic acid (the other is RNA); a complex organic compound found in all living cells and many viruses. It is the chemical substance of genes.
, then what could spring from cloned humans?

Cloning first hit the front page with the birth of Dolly in 1997, a lamb created using the nucleus of a cell from her mother's body. Even before then, decision makers were debating the ethics of human cloning Although genes are recognized as influencing behavior and cognition, "genetically identical" does not mean altogether identical; identical twins, despite being natural human clones with near identical DNA, are separate people, with separate experiences and not altogether . In fact, researchers began laying the foundation for cloning technology more than 100 years ago. The clamor of debate, however, was fueled as never before by an announcement last December that an obscure religious sect had, indeed, cloned a human being.

"Cloning a baby is just the first step" toward human immortality, said former French journalist Claude Vorihon, who calls himself Rael and claims to be a direct descendant of extraterrestrials who created life on earth through genetic engineering.

In fact, the Raelian's commercial offshoot, Clonaid, says they have cloned several human babies in recent months. Although Clonaid has not allowed scientists to conduct genetic tests to prove their contentions, the announcements have ignited an incendiary INCENDIARY, crim. law. One who maliciously and willfully sets another person's house on fire; one guilty of the crime of arson.
     2. This offence is punished by the statute laws of the different states according to their several provisions.
 policy debate.

Clonaid's claims, however, have not caught lawmakers by surprise. Since Dolly, the number of cloning bills introduced in state legislatures has grown each session. From 2001 to 2002 alone, the number of states taking on the issue quadrupled. The flurry of legislative activity has resulted in laws that restrict, prohibit or even encourage some forms of human cloning in seven states. The debate also has led lawmakers to examine the use of cloned embryos for stem cell stem cell

In living organisms, an undifferentiated cell that can produce other cells that eventually make up specialized tissues and organs. There are two major types of stem cells, embryonic and adult.


The process of human cloning begins with removal of the nucleus from a human cell, such as a skin cell and transferring it to a woman's egg cell from which the nucleus has been removed. Through electrical stimulation, the egg cell then begins to divide. In reproductive cloning reproductive cloning
The genetic duplication of an existing organism especially by transferring the nucleus of a somatic cell of the organism into an enucleated oocyte.
, the egg cell continues to develop into an embryo that is subsequently implanted into a woman's uterus. If the procedure leads to a live birth, the resulting human primarily inherits the person's genetic material from which the cell was taken. The clone also would carry traces of mitochondrial DNA Mitochondrial DNA (mtDNA) is the DNA located in organelles called mitochondria. Most other DNA present in eukaryotic organisms is found in the cell nucleus. Nuclear and mitochondrial DNA are thought to be of separate evolutionary origin, with the mtDNA being derived from the  found in the cytoplasm cytoplasm: see protoplasm.

Portion of a eukaryotic cell outside the nucleus. The cytoplasm contains all the organelles (see eukaryote).
 (the substance the surrounds the nucleus) of the egg cell.

Therapeutic cloning therapeutic cloning
A procedure in which damaged tissues or organs are repaired or replaced with genetically identical cells that originate from undifferentiated stem cells.
, or cloning for the purpose of research, begins in the same way, but development of the organism is typically halted during an early (blastocyst blastocyst /blas·to·cyst/ (-sist) the mammalian conceptus in the postmorula stage, consisting of an embryoblast (inner cell mass) and a thin trophoblast layer enclosing a blastocyst cavity. ) stage when the original cell has divided into eight cells. Then, stem cells stem cells, unspecialized human or animal cells that can produce mature specialized body cells and at the same time replicate themselves. Embryonic stem cells are derived from a blastocyst (the blastula typical of placental mammals; see embryo), which is very young , which have the unique ability to generate specialized cells, such as liver cells or brain cells, are extracted for use in scientific research.


Although the U.S. House of Representatives passed a measure to ban both therapeutic and reproductive cloning in February, the bill is waiting action in the Senate at press time. Several competing bills that would prohibit all or some forms of human cloning are also pending in Congress. Even so, federal regulations already restrict the activities of federally funded researchers.

Former President Bill Clinton established the first federal policy to directly address reproductive and therapeutic cloning with an executive order that prohibited certain activities related to embryonic research, including human cloning, in federally funded projects. And President Bush addressed the nation in August 2001 to announce that researchers could not use federal money to harvest new cells from embryonic stem cells. Studies on cells already generated are permitted.

There is no federal law prohibiting reproductive or therapeutic cloning using private money. In a 1993 notice, the Food and Drug Administration (FDA FDA
Food and Drug Administration

FDA, See Food and Drug Administration.

FDA, the abbreviation for the Food and Drug Administration.
) announced that it would regulate reproductive cloning. The agency requires researchers to submit an application to conduct studies involving biological products. Former director of the Center for Biologics Evaluation and Research The Center for Biologics Evaluation and Research (CBER) is one of six main centers for the Food and Drug Administration, which is in the United States Department of Health and Human Services.  (CBER CB·er  
One that uses a CB radio.
) at the FDA Kathryn Zoon See Zune.  testified to Congress in 2001: "FDA believes that there are major, unresolved safety questions on the use of cloning technology to clone a human being and, therefore, would not permit any such investigation to proceed at this time." The FDA's position remains unchanged.


In the absence of a federal law, states have taken on human cloning in increasing numbers. Most recently, Iowa banned all forms of human cloning in its 2002 session. "The federal government wasn't moving fast enough," says Senator Maggie Tinsman. "We were really concerned about human cloning.

Iowa legislators were not the first to worry. California established the earliest state law in 1997. Since then, Iowa, Louisiana Iowa is a town in Calcasieu Parish, Louisiana, United States. The population was 2,663 at the 2000 census. History
The history of this region is filled with stories of the early Midwestern Settlers from Kansas, Illinois and Iowa to the French Canadians (Cajuns) to Jean
, Michigan, Missouri, Rhode Island Rhode Island, island, United States
Rhode Island, island, 15 mi (24 km) long and 5 mi (8 km) wide, S R.I., at the entrance to Narragansett Bay. It is the largest island in the state, with steep cliffs and excellent beaches.
 and Virginia have followed suit. This session, some 43 bills had been introduced in 19 states by the first of March. In Indiana, New Jersey and North Dakota North Dakota, state in the N central United States. It is bordered by Minnesota, across the Red River of the North (E), South Dakota (S), Montana (W), and the Canadian provinces of Saskatchewan and Manitoba (N).  bills had passed in one chamber.

Every state with a human cloning law has a ban or a moratorium on reproductive cloning with the exception of Missouri, which prohibits only the use of state funds for reproductive cloning. California legislators revisited the state's law in 2002 and removed the sunset clause. Similarly, the Rhode Island General Assembly The State of Rhode Island General Assembly is the state legislature of the U.S. state of Rhode Island. A bicameral body, it is composed of the lower Rhode Island House of Representatives with 75 Representatives, and the upper Rhode Island Senate with 38 Senators.  extended its moratorium on reproductive cloning until July 2010.

Human cloning prohibitions also apply to therapeutic cloning in Iowa and Michigan. In addition, Virginia's law also may forbid therapeutic cloning. The statute defines human cloning as the attempt to create a human being using nuclear transfer technology, but there is disagreement about whether "human being" covers embryos or blastocysts. Although these laws limit potential sources for research, they do not outlaw the use of embryonic stem cells altogether.


Four main sources exist for embryonic stem cells: stem cell lines that have already been developed, cloned embryos, germ cells--sperm or egg cells--from terminated pregnancies or miscarriages and unused in vitro in vitro /in vi·tro/ (in ve´tro) [L.] within a glass; observable in a test tube; in an artificial environment.

in vi·tro
In an artificial environment outside a living organism.
 fertilized fer·til·ize  
v. fer·til·ized, fer·til·iz·ing, fer·til·iz·es
1. To cause the fertilization of (an ovum, for example).

 embryos. Myriad state laws restrict or prohibit research on cells or tissue obtained from some or all of these sources. However, contrary to the president's position, the majority of states permit embryonic stem cell research using public and private funds on all four sources of stem cells. But the use of cloned embryos presents unique concerns.

The safety issues associated with reproductive cloning lead most people to quickly reject the idea. Many animal clones, for example, have suffered from genetic and other defects for reasons not yet understood. Thomas Murray This article refers to the Scottish curler. For other people named, Thomas Murray, see Thomas Murray (disambiguation).

Tom Murray was a Scottish curler. He was part of the Royal Caledonian Curling Club team which won the first Olympic gold medal in curling at the inaugural
 of the Hastings Center The Hastings Center, founded in 1969, is an independent, nonpartisan, non-profit bioethics research institute dedicated to examination of essential questions in health care, biotechnology, and the environment. , a nonpartisan research institution, also notes that the failure rate for reproductive cloning is high, and although some embryos with abnormalities die early on, others continue to develop.

But when it comes to cloning for research, policymakers may take into account other complex ethical considerations. Murray explains that individuals who believe that a human embryo is a "morally significant entity, but something other than a full-fledged entity" are more likely to weigh the ethical concerns about cloning for research vs. the potential to treat patients with serious ailments.

To the United States Conference of Catholic Bishops, cloned embryos deserve the same protections as other human research subjects. "In moral terms, we think that creating human lives solely to destroy them is more problematic than cloning for procreation PROCREATION. The generation of children; it is an act authorized by the law of nature: one of the principal ends of marriage is the procreation of children. Inst. tit. 2, in pr. ," says spokesman Richard Doerflinger.

The cloning debate generates much interest. Legislators hear from religious organizations, medical centers, abortion groups, ethicists and individuals who suffer from diseases like Parkinson's or spinal cord injuries Spinal Cord Injury Definition

Spinal cord injury is damage to the spinal cord that causes loss of sensation and motor control.

Approximately 10,000 new spinal cord injuries (SCIs) occur each year in the United States.
 who might benefit from stem cell therapy stem cell therapy Cell therapy Molecular medicine A technology in which a person's own cells–eg, neuronal stem cells are triggered to revert to their primitive embryonic form, then redifferentiate into mature cells of various organs .

Senator Tinsman says scientists from the University of Iowa Not to be confused with Iowa State University.
The first faculty offered instruction at the University in March 1855 to students in the Old Mechanics Building, situated where Seashore Hall is now. In September 1855, the student body numbered 124, of which, 41 were women.
 came to testify and "admitted that they had not actually used embryos for stem cell research. But it was going to happen, and they wanted to be in on the ground floor."

When South Dakota legislators considered a bill to prohibit all embryonic research in 2000, however, researchers were not as involved. "The university did not play a major part in the debate because I think the majority of people thought it through and decided [research on embryos] is not the thing to do even though it might bring in research dollars," says Senator Jay L. Duenwald.

In the end, the South Dakota Legislature enacted the tightest restrictions on embryonic research in the United States. The law prohibited research on existing stem cell lines even before the president adopted his policy.

"We knew that we were taking a ground breaking approach," says Duenwald. "We were looking ahead to what might be coming down the road."

The South Dakota embryonic research ban also is unique in that it addresses stem cell research while avoiding the cloning debate. Reproductive and therapeutic cloning are still permitted in the state. You cannot destroy an embryo for research purposes, but you can create one. The cloned embryo can be frozen, disposed of or implanted in a woman's uterus, but not used in experiments.

South Dakota legislators are not the only ones who have been creative. California Senator Deborah Ortiz sponsored seminal legislation enacted in 2002 to specifically permit research on stem cells, including cells from cloned embryos, embryonic germ cells and adult stem cells. For her, stem cell research struck a personal chord: "My interest in stem cells resulted from my work on cancer research when my mother was ill ...I was really searching for a cure to stop the cancer that ultimately took my mother's life." Through her ordeal, Ortiz says that she "became aware of the incredible potential for stem cell research to alleviate chronic and fatal diseases."

Although therapeutic cloning and embryonic stem cell research already were legal in the state, the bill gave legislators an opportunity to send a message to biomedical bi·o·med·i·cal
1. Of or relating to biomedicine.

2. Of, relating to, or involving biological, medical, and physical sciences.
 researchers that the state supports stem cell research. Senator Ortiz reports that since the law was passed, California has lured away researchers from other states. The law requires that an institutional review board, typically comprised of scientists, ethicists, consumer representatives and religious leaders, oversee the work of stem cell scientists. In addition, fertility patients must be given the option to store unused frozen embryos, discard them, donate them to another individual or donate them to science.

This approach has sprouted a new branch of legislative activity. Before California, no state had specifically addressed stem cell research in legislation. Since then, several states have considered bills encouraging stem cell research.

In the end, it's too soon to tell what the role of this technology, which remains in its infancy, will be in our society. Broad-based acceptance of reproductive cloning, though, appears a long way off.

If cloning a baby was safe--what then? The Hastings Center's Murray remarks, "First of all, the idea that cloning will ever be safe is a heroic assumption. Let's say though, that it was true ... Cloning then would raise an additional set of questions. Why would people want to do it? The best argument against reproductive cloning is if someone does clone Michael Jordan, the kid might really want to be an accountant and could care less about playing basketball. Michael Jordan is so much more than just his physical being. He has a certain character, a certain drive, a certain personality. And you can't expect that you will achieve that."

As scientists deliberate if and when such a scenario might be possible, state legislators continue to grapple with to enter into contest with, resolutely and courageously.

See also: Grapple
 the potential consequences. In a world of uncertainty, policymakers can rely on one sure thing: Just when legislators grasp the seemingly unanswerable questions surrounding human cloning, genetic technology will surely throw them a new curve.

                    Prohibits             Prohibits
State         Reproductive Cloning   Therapeutic Cloning

California             Yes
Iowa                   Yes                   Yes
Louisiana        Until July 2003
Michigan               Yes                   Yes
Missouri      Prohibits state funds
Rhode Island     Until July 2010
Virginia               Yes                 Unclear


Significant research developments transpired as SB 253 to support stem cell research moved through the California Legislature and, ultimately, was signed into law in September 2002:

* While the Assembly prepares to consider the bill, the University of California The University of California has a combined student body of more than 191,000 students, over 1,340,000 living alumni, and a combined systemwide and campus endowment of just over $7.3 billion (8th largest in the United States).  San Francisco (UCSF UCSF University of California at San Francisco ) announces a new stem cell initiative after the chairman of Intel, Andy Grove, presents UCSF with a $5 million matching grant matching grant Academia Non-peer-reviewed funding in which a commercial enterprise, foundation, or philanthropy, federal government, contributes a sum of money that 'matches' a financial contribution made by an institution, university or hospital.  to start the UCSF Stem Cell Discovery Fund. For every contribution to the fund ranging from $50,000 to $500,000, Grove will match the donation.

* After receiving a $12 million anonymous donation to start the project, Stanford University launches the Institute for Cancer/Stem Cell Biology and Medicine on Dec. 10, 2002. Dr. Irving Weissman leads the institute's efforts to find new therapies for cancer, diabetes, Parkinson's and other diseases using adult and embryonic stem cells.

* Renowned researcher Dr. Evan Snyder relocates to The Burnham Institute in La Jolla, Calif., from Harvard University on Jan. 1, 2003. Snyder says that the new law was a factor in his decision to move. He directs the institute's program on stem cells and regenerative medicine.


The cloning conundrum. A modern dilemma, right? Not so. Efforts to clone various creatures began in the 1800s.

In the beginning, scientists were trying to clone sea urchins and frogs. Early success was limited to embryos. The technology to clone mammal embryos surfaced in 1983. But the ability to clone adult mammals evaded scientists for another 14 years. That's why Dolly, a clone of an adult sheep, was a major achievement.

1894 Hans Dreisch isolates cells of two- and four-cell embryos of sea urchins and observes development of cells into small but complete larvae Larvae, in Roman religion
Larvae: see lemures.

1901 Hans Spemann splits a two-cell newt embryo into two parts, successfully producing two larvae.

1914 Spemann conducts early nuclear transfer. Using a strand of baby hair, he partially constricts a newly fertilized egg cell, forcing the nucleus to one side and only cytoplasm to the other. As the nucleus side of the cell divides successively to the 16-cell stage, a nucleus slips over to the cytoplasm on the other side. Cell division starts on this side also, and the hair knot is tightened, preventing further nuclear transfer. Twin larvae develop, one slightly older than the other.

1940s - 1950s Various species of mammalian embryos are cloned by embryo splitting, but success is limited to early stage embryos.

1952 Robert Briggs and Thomas J. King

For other people named Thomas King, see Thomas King (disambiguation).
Thomas J. King (1921 - October 25, 2000) was an American biologist.

With Robert W.
 transplant a nucleus of a frog embryo cell into an unfertilized Adj. 1. unfertilized - not having been fertilized; "an unfertilized egg"
unfertilised, unimpregnated

infertile, sterile, unfertile - incapable of reproducing; "an infertile couple"
 egg cell with the nucleus removed. These injected eggs develop into tadpoles Tadpoles are a psychedelic rock band formed in 1990 in New York City by Todd Parker (guitars/vocals) and Michael Kite Audino (drums.) In 1992, Nick Kramer (guitars/vocals), David Max (bass) and Andrew Jackson (guitars) of the fledgling Manhattan group, Hit, joined the Tadpoles  and many grow into juvenile frogs. This technique, nuclear transfer, becomes the prototype for cloning of multicelled organisms.

1964 F.C. Steward grows a complete carrot plant from a carrot root cell.

1970s Using nuclear transfer, researchers produce larvae from the nuclei of adult frog cells.

1983 James McGrath and Davor Solter develop nuclear transfer technology for mammalian embryos.

1986 Steen Willadsen clones lambs by fusing the nucleus of an eightcell embryo to an egg cell with the nucleus removed. Other researchers subsequently succeed in producing full-term cattle, sheep, pigs, goats and rats using a similar approach.

1997 lan Wilmut and his colleagues from Scotland produce Dolly, the first mammal cloned from an adult cell.

1998 A Honolulu group, led by Teruhiko Wakayama, reports the production of a large number of live mice by injecting nuclei taken from adult ovarian cells into egg cells with the nucleus removed. These investigators also report success in recloning the first clones. A Japanese group, led by Yoko Kato, produce eight calves from various cells derived from one adult donor.

2001 Advanced Cell Technology of Worcestor, Mass., reports the creation of the first cloned human embryos for stem cell research. None of the organisms develop past the six-cell stage.

2002 Clonaid announces the birth of the first human clone, but scientists are skeptical. Clonaid does not allow its claims to be verified by genetic testing Genetic Testing Definition

A genetic test examines the genetic information contained inside a person's cells, called DNA, to determine if that person has or will develop a certain disease or could pass a disease to his or her offspring.

Source: "Cloning: Past, Present and Future," by Marie DiBerardino in Breakthroughs in Bioscience from the Federation of American Societies for Experimental Biology The Federation of American Societies for Experimental Biology, or FASEB, is a non-profit federation of 21 societies for biomedical research in the United States. Its mission statement is "to advance biological science through collaborative advocacy for research policies that , 1999.

Alissa Johnson tracks genetics Issues for NCSL NCSL National Conference of State Legislatures
NCSL National College for School Leadership
NCSL National Conference of Standards Laboratories
NCSL National Council of State Legislators
NCSL National Computer Systems Laboratory (NIST) 
COPYRIGHT 2003 National Conference of State Legislatures
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Author:Johnson, Alissa
Publication:State Legislatures
Article Type:Brief Article
Date:Apr 1, 2003
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