Atrium Medical, Isotechnika announce licensing agreements for use of new drugs with medical devices.Atrium Medical Corporation, Hudson, N.H. and Isotechnika, Inc., Edmonton, Alberta, Canada, jointly announced the signing of an exclusive worldwide licensing agreement for the use of TAFA TAFA Tonga Australian Football Association TAFA Thai Airfreight Forwarders Association TAFA The Arcade Flyer Archive (archive of advertising flyers for coin-op video, pinball and arcade games) TAFA Thermal Acoustic Fatigue Apparatus 93 and ISA (1) (Instruction Set Architecture) See instruction set. (2) (Interactive Services Association) See Internet Alliance. (3) (Internet Security and Acceleration) See .NET. 247 specifically with drug eluting devices for the local, non-systemic treatment of vascular and cardiovascular disorders, soft tissue repair, and a variety of other uses related to Atrium's implantable products. The companies say TAFA93 is a novel prodrug of rapamycin (an mTOR inhibitor) with powerful anti-proliferative effects similar to several other known mTOR inhibiting compounds but with improved pharmacokinetic properties. Atrium says it has demonstrated a significant biological effect in pre-clinical coronary drug eluting coronary stent coronary stent Intracoronary stent Cardiology An expandable tubular device which can be inserted percutaneously, and left within a coronary artery lumen to maintain its patency Pros Clinical and angiographic outcomes are better with intracoronary artery stent models using its Flyer coronary stent coated with TAFA93 in its Alpha3 bioabsorbable oil coating. The second licensed drug - ISA247 is a new cyclosporine cyclosporine /cy·clo·spor·ine/ (-spor´en) a cyclic peptide from an extract of soil fungi that selectively inhibits T cell function; used as an immunosuppressant to prevent rejection in organ transplant recipients and to treat severe derivative or calcineurin inhibitor currently in Phase III human clinical trials. Isotechnika says it is studying the drug for a number of indications including the treatment of psoriasis and for the prevention of organ rejection in renal transplant renal transplant Transplantation of a kidney from a living donor or cadaver to a recipient with ESRD Indications–children Congenital kidney/GU tract malformations–42%; focal segmental glomerulosclerosis-12% and others; 31% of children were ≤ age 5 patients. Contact: Atrium Web site: www.atriummed.com, or Isotechnika Web site: www.isotechnika.com. |
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