Atopic dermatitis and stress? How do emotions come into skin?It is widely accepted, that stress can induce or exacerbate atopic dermatitis. The physiological mechanisms that mediate this negative influence of stress on atopic dermatitis are not clearly understood. This topic has been actively investigated in recent years focusing on neuroimmunological, psychoendocrinological studies and examination of integrity and function of skin barrier under stress. Different neuropeptides neuropeptides (ner·ō·pepˑ·tīdz), n.pl endogenous protein molecules that influence neural activity by carrying information directly to the cells and tissues. and neurotrophins seem to play an important role in stress-induced neurogenic inflammation and connection of nervous and immune system. Mast cells play a key role in the development of inflammatory reaction to stress. Skin barrier is altered by stress by means of increased cortisol cortisol (kôr`tĭsôl') or hydrocortisone, steroid hormone that in humans is the major circulating hormone of the cortex, or outer layer, of the adrenal gland. level. Thereby lamellar lamellar /la·mel·lar/ (lah-mel´ar) 1. pertaining to or resembling lamellae. 2. lamellated (1). lamellar pertaining to or emanating from lamella. body secretion is decreased and epidermal Epidermal Referring to the thin outermost layer of the skin, itself made up of several layers, that covers and protects the underlying dermis (skin). Mentioned in: Antiangiogenic Therapy, Histiocytosis X epidermal expression of antimicrobial peptides (beta-defensin and cathelicidin) is down-regulated. We review recent investigations in this field. Hautarzt. 2008 Apr;59(4):314-8 |
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