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Atlantic Technology Ventures, Inc. Licenses World Wide Rights to ATV-02 Antimicrobial Agent.


Business Editors/Health & Medical Writers

Atlantic Technology Ventures, Inc. (OTC OTC

See: Over-the-counter.


OTC

See over-the-counter market (OTC).
:ATLC) has licensed from its inventors the worldwide rights to ATV-02, a potent and broad-spectrum antimicrobial agent for the local treatment of topical infections. The compound has already completed safety and tolerability studies in a limited number of subjects, and has begun a series of phase II human clinical studies for the treatment of several indications, including viral and bacterial conjunctivitis conjunctivitis (kənjəngtəvī`təs), inflammation or infection of the mucosal membrane that covers the eyeball and lines the eyelid, usually acute, caused by a virus or, less often, by a bacillus, an allergic reaction, or an , and acute and chronic sinusitis. The terms of the deal were not disclosed.

As a broad-spectrum drug with bactericidal bactericidal /bac·te·ri·ci·dal/ (bak-ter?i-si´d'l) destructive to bacteria.
Bactericidal
An agent that destroys bacteria (e.g.
, virucidal and fungicidal activity, ATV-02 has the potential of being a viable alternative to the use of antibiotics for the treatment of local infections. Since their discovery over a half a century ago, the misuse and overuse of antibiotics has caused a crisis of antibiotic resistant bacteria. In contrast to antibiotics, ATV-02 is as a human disinfectant that is not expected to promote drug resistant bacteria.

"We are very excited about the broad-spectrum potential of ATV-02 to treat local infections," commented Fred Zotos, President and CEO (1) (Chief Executive Officer) The highest individual in command of an organization. Typically the president of the company, the CEO reports to the Chairman of the Board.  of Atlantic. "Licensing ATV-02 further affirms our business model of finding therapeutics and medical technologies that address unmet market needs, rapidly developing these through a definitive proof-of-principle, then partnering, licensing or selling them to realize a progressive revenue stream."

About ATV-02

ATV-02 is a long-lived endogenous oxidant that is normally produced in the body by human granulocytes Granulocytes
White blood cells.

Mentioned in: Blood Donation and Registry

granulocytes (granˑ·y
 and monocytes monocytes,
n.pl the largest of the white blood cells. They have one nucleus and a large amount of grayish-blue cytoplasm. Develop into macrophages and both consume foreign material and alert T cells to its presence.
. It demonstrates immune modulatory properties exerted by down regulation of proinflammatory cytokines such as tumor necrosis factor tumor necrosis factor
n. Abbr. TNF
A protein that is produced in the presence of an endotoxin, especially by monocytes and macrophages, is able to attack and destroy tumor cells, and exacerbates chronic inflammatory diseases.
, nitric oxide, and protaglandins. Oxidants are important tools that stimulate human phagocytes used to attack and kill pathogens. Besides its immune controlling function, ATV-02 has demonstrated broad-spectrum bactericidal, virucidal, fungicidal and vermicidal ver·mi·cid·al
adj.
Destructive to parasitic intestinal worms.
 activity, along with very low cytotoxicity against human cells and sufficient stability.

All the human clinical studies completed to date have been conducted at the University of Innsbruck It is currently the largest education facility in the Austrian Bundesland of Tirol and third largest in Austria according to student population, behind Vienna University and Graz University. , Austria under the direction of the inventors: Dr. Waldemar Gottardi, Dr. Markus Nagl and Dr. Andreas Neher. These studies have all been approved by the Innsbruck Ethics Committee according to GCP (Good Clinical Practice) guidelines, were registered by the Austrian Ministry of Health, and funded by various philanthropic sources including the Austrian Science Fund and the Jubilee Research Fund of the Austrian National Bank.

"Atlantic will continue to evaluate the safety and efficacy of ATV-02 throughout the completion of the ongoing clinical studies being conducted in Innsbruck," stated Michael Ferrari, Vice President of Business Development for Atlantic. "Upon successful completion of these studies, Atlantic will take all necessary actions to continue developing ATV-02 in Europe and begin filing an IND in the US to develop it according to FDA FDA
abbr.
Food and Drug Administration


FDA,
n.pr See Food and Drug Administration.

FDA,
n.pr the abbreviation for the Food and Drug Administration.
 regulations for approval in the US."

About Sinusitis

Sinusitis, or inflammation of the membrane lining the sinuses, is usually caused or complicated by a bacterial, viral or fungal infection. It's the most common reason for office-visit prescription of antibiotics in adults in the United States, and affects an estimated 14 percent of the population according to a report published in the June issue of The Journal of Allergy and Clinical Immunology The Journal of Allergy and Clinical Immunology is a scientific journal in the field of allergy and immunology, with an emphasis on clinical relevance. It's the official journal of the American Academy of Allergy, Asthma, and Immunology. . It is estimated to result in over 13 million office visits per year. Figures suggest the total annual direct cost of treatment, including drugs, office visits to doctors and surgery, is in excess of US $2.4 billion.

About Conjunctivitis

Conjunctivitis, or "pink eye", is a bacterial or viral infection of the eye's conjunctiva, and is probably the most common infection seen in eye doctors' offices. It is a very contagious disease and causes symptoms such as tearing, redness and swelling of the conjunctiva, purulent pu·ru·lent
adj.
Containing, discharging, or causing the production of pus.


Purulent
Consisting of or containing pus

Mentioned in: Lacrimal Duct Obstruction


purulent

containing or forming pus.
 discharge and light sensitivity. Conjunctivitis usually takes up to two weeks to run its course, and there remains no effective treatment to date for viral conjunctivitis.

About Atlantic Technology Ventures, Inc.

Atlantic is engaged in the development of biomedical and pharmaceutical products and related technologies. Atlantic's strategy is to identify nascent medical products and technologies that have the potential to address unmet market needs, rapidly develop these through a definitive proof-of-principle, then partner, license or sell them to realize significant revenue. Atlantic currently has ownership interest in Avantix (formerly known as "Catarex"), a surgical device for cataract removal being under development by Bausch and Lomb, and CT-3, a synthetic cannabinoid cannabinoid /can·nab·i·noid/ (kah-nab´i-noid) any of the principles of Cannabis, including tetrahydrocannabinol, cannabinol, and cannabidiol.

can·nab·i·noid
n.
 derivative for treating pain and inflammation under development by Indevus Pharmaceuticals.

Safe Harbor Statement

Cautionary statement under the "safe harbor" provisions of the Private Securities Litigation Reform Act The Private Securities Litigation Reform Act of 1995 (PSLRA) implemented several significant substantive changes affecting certain cases brought under the federal securities laws, including changes related to pleading, discovery, liability, class representation and awards fees and  of 1995: This press release contains certain forward-looking statements that relate to future scientific, business and financial performance. These statements are only predictions and are subject to a number of risks and uncertainties that may cause the actual events or results to differ from those discussed or implied in these statements. These risks and uncertainties include competition from other manufacturers of related technologies, the unavailability of any necessary intellectual property rights possessed by third parties, and certain of those risks described in Atlantic's most recent report on Form 10-KSB with the Securities and Exchange Commission.
COPYRIGHT 2002 Business Wire
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2002, Gale Group. All rights reserved. Gale Group is a Thomson Corporation Company.

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Publication:Business Wire
Geographic Code:1USA
Date:Jul 9, 2002
Words:830
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