Aspartame not linked to cancer.In an article published in the March 2006 issue of Environmental Health Perspectives (EHP EHP
1. effective horsepower
2. electric horsepower ) Soffritti et al. (2006) of the European Ramazzini Foundation of Oncology and Environmental Sciences (ERF n. 1. A garden plot, usually about half an acre. ) reported that aspartame aspartame: see sweetener, artificial.
Synthetic organic compound (a dipeptide) of phenylalanine and aspartic acid. It is 150–200 times as sweet as cane sugar and is used as a nonnutritive tabletop sweetener and in low-calorie was associated with an increase in lymphomas and leukemias, transitional cell carcinomas of the renal pelvis and urether, malignant schwanomas of peripheral nerves Peripheral nerves
Nerves throughout the body that carry information to and from the spinal cord.
Mentioned in: Amyloidosis, Charcot Marie Tooth Disease , and hyperplasia of the olfactory epithelium olfactory epithelium
Pseudostratified epithelium that contains olfactory, receptor, and nerve cells whose axons connect with the olfactory bulb of the brain. .
After the publication of the ERF aspartame study (Soffritti et al. 2006), the European Commission asked the European Food Safety Authority The European Food Safety Authority (EFSA), an agency of the European Union, began operating in 2002. Its permanent home is in Parma, Italy.
Its primary responsibility is to provide independent scientific advice on all matters concerning food safety. (EFSA EFSA European Food Safety Authority
EFSA European Federation of Sea Anglers
EFSA European Food Safety Association ) to assess the ERF aspartame carcinogenicity carcinogenicity /car·ci·no·ge·nic·i·ty/ (kahr?si-no-je-nis´i-te) the ability or tendency to produce cancer.
the ability or tendency to produce cancer. study results as a matter of high priority following the publication (EFSA 2005). The EFSA's Scientific Panel on Food Additives, Flavorings, Processing Aids and Materials in Contact with Food (AFC (1) (Application Foundation Classes) A class library from Microsoft that provides an application framework and graphics, graphical user interface (GUI) and multimedia routines for Java programmers. ), an 18-member panel that consisted of independent regulatory scientists and toxicologists, assessed the ERF aspartame carcinogenicity study using not only the ERF publication but also more extensive primary data and reports provided by ERF (EFSA 2006). Concurrently, the U.K. Food Standards Agency The Food Standards Agency is a non-ministerial government department of the Government of the United Kingdom. It is responsible for protecting public health in relation to food throughout the United Kingdom and is led by an appointed board that is intended to act in the public requested the opinion of the U.K. Committee on Carcinogenicity of Chemicals in Food, Consumer Products and Environment (COC See chip on chip. ) on the quality, analysis, and interpretation of the results of the ERF aspartame carcinogenicity study (Soffritti et al. 2006).
After a lengthy evaluation process, on 5 May 2006, the EFSA published a 44-page report (EFSA 2006). A summary comment of the EFSA report on ERF study included the following:
The increased incidence of lymphomas/leukaemias reported in treated rats was unrelated to aspartame, given the high background incidence of chronic inflammatory changes in the lungs and the lack of a positive dose-response relationship.... The slight increase in incidence of these tumours in rats fed aspartame is considered to be an incidental finding of the ERF study and can therefore be dismissed. (EFSA 2006) The preneoplastic and neoplastic lesions of the renal pelvis, ureter and bladder occurring primarily in female rats along with renal calcification were most probably treatment-related, at least at the higher doses. It is widely accepted that the effect is a high dose effect of irritant chemicals or chemicals producing renal pelvic calcification as a result of imbalances in calcium metabolism, specific to the rat. The Panel considers that these effects are of no relevance for humans. (EFSA 2006) The data on total malignant tumours do not provide evidence of a carcinogenic potential of aspartame.... [T]he aggregation of all malignant tumour incidences or all malignant tumour-bearing animals for statistical purposes is not justified, given that, as explained above, the lymphomas/leukaemias and the renal tumours should have been excluded from the analysis. (EFSA 2006) Concerning the malignant schwannomas,... the numbers of tumours were low, the dose-response relationship, while showing a positive statistical trend in males, was very flat over a wide dose range and there is also uncertainty about the diagnosis of these tumours.... This finding can only be fully evaluated following a histopathological peer-review of all relevant slides related to the nervous system in the ERF study and if necessary also from the historical controls. (EFSA 2006)
Furthermore, the COC's March 2006 minutes on the publication of the ERF aspartame study (Soffritti et al. 2006) concluded,
... In view of the problems in the design of the study and some concerns about the microbiological status of the colony, it was not possible to draw conclusions about the potential carcinogenicity of aspartame from the results.
The study by Soffritti et al. (2006) has major flaws that bring into question the validity of the findings. Its publication in EHP is not without consequence to the reputation of the National Institute of Environmental Health Sciences The National Institute of Environmental Health Sciences (NIEHS) is one of 27 Institutes and Centers of the National Institutes of Health (NIH),which is a component of the Department of Health and Human Services (DHHS). The Director of the NIEHS is Dr. David A. Schwartz. or to the health of the U.S. public. Publication of invalid and misleading research results relating to products such as aspartame, which can be of benefit in the battle against obesity and have a history of safe use, are a disservice to the tax-paying citizens of the United States.
The author is employed by Ajinomoto USA, which sells aspartame.
Eyassu G. Abegaz
Aginomoto Corporate Services LLC (Logical Link Control) See "LANs" under data link protocol.
LLC - Logical Link Control Washington, DC
COC. 2006. Minutes of the Meeting Held at 10.30am on Thursday 2 March 2006, Item 5: Ramazzini Study on the Carcinogenicity of Aspartame (CC/06/6). London: Committee on Carcinogenicity of Chemicals in Food, Consumer Products and Environment. Available: http://www.advisorybodies.doh.gov.uk/pdfs/wpmin020306.pdf [accessed 17 May 2006].
EFSA. 2005. EFSA Urges the Ramazzini Institute to Release Data on Aspartame. Available: http://www.efsa.europa.eu/en/press_room/press_release/2005/1228.html [accessed 17 May 2006].
EFSA. 2006. Opinion of the Scientific Panel AFC Related to a New Long-term Carcinogenicity Study on Aspartame. Parma, Italy: European Food Safety Authority. Available: http://www.efsa.eu.int/science/afc/afc_opinions/1471_en. html [accessed 17 May 2006].
Soffritti M, Belpoggi F, Esposti DD, Lambertini L, Tibaldi E, Rigano A. 2006. First experimental demonstration of the multipotential carcinogenic carcinogenic
having a capacity for carcinogenesis. effects of aspartame administered in the feed of Sprague-Dawley rats. Environ Health Perspect 114:379-385.