Array BioPharma to Present Clinical Data at the European League Against Rheumatism (EULAR) Annual Meeting and the 8th World Congress on Inflammation.BOULDER, Colo. -- Array BioPharma Inc. (Nasdaq: ARRY) today announced that its scientific team will present clinical data on the MEK Noun 1. MEK - a terrorist organization formed in the 1960s by children of Iranian merchants; sought to counter the Shah of Iran's pro-western policies of modernization and opposition to communism; following a philosophy that mixes Marxism and Islam it now attacks the inhibitor, ARRY-162 and p38 inhibitor, ARRY-797, at the Annual European Congress of Rheumatology rheumatology /rheu·ma·tol·o·gy/ (-tol´ah-je) the branch of medicine dealing with rheumatic disorders, their causes, pathology, diagnosis, treatment, etc. rheu·ma·tol·o·gy n. (EULAR) in Barcelona, Spain and the International Association of Inflammation Societies' (IAIS IAIS International Association of Insurance Supervisors IAIS Irish American Information Service IAIS Improved Avionics Intermediate Shop IAIS I Am I Said (Neil Diamond) IAIS Iowa Interstate Railroad System ) 8th World Congress on Inflammation in Copenhagen, Denmark.
Event: European League Against Rheumatism (EULAR) Annual Meeting
Date: Saturday, June 16, 2007
Location: CCIB -Barcelona International Convention Center, Spain
Title: ARRY-162, a selective, potent MEK 1 / 2 inhibitor,
significantly reduces ex vivo IL-1(beta) and TNF(alpha)
production in normal human subjects
Presenter: Kevin Koch, Ph.D, President and Chief Scientific Officer
Title: ARRY-797, a selective, potent inhibitor of p38, promotes
disease normalization in animal models of rheumatoid
arthritis and significantly reduces ex vivo IL-1(beta),
PGE2 and TNF(alpha) production in normal human subjects
Presenter: Patrice Lee, Ph.D., Director, Pharmacology and Toxicology
Event: IAIS' 8th World Congress on Inflammation
Location: Bella Center, Copenhagen, Denmark
Title: The effects of MEK Inhibitors in Cancer and Inflammation
Presenter: Kevin Koch, Ph.D, President and Chief Scientific Officer
Date: Sunday, June 17, 2007 at 10:30 a.m.
Title: ARRY-797, a selective, potent inhibitor of p38 active in
animal models of rheumatoid arthritis, inhibits ex vivo
IL-1, PGE2 and TNF production in normal human subjects
Presenter: Kevin Koch, Ph.D, President and Chief Scientific Officer
Date: Monday, June 18, 2007 at 5:15 pm
Title: ARRY-162, a selective, potent MEK 1 / 2 inhibitor,
significantly reduces ex vivo IL-1 and TNF production in
normal human subjects
Presenter: James Winkler, Ph.D., Senior Director, Discovery Biology
Date: Wednesday, June 20, 2007 at 11:15 am
Title: Soft, topical immunosuppressants derived from Cyclosporin
A for the treatment of atopic dermatitis
Presenter: Laurence Burgess, Ph.D., Senior Director, Medicinal
Chemistry and Lead Optimization
Date: Tuesday, June 19, 2007 at 5:45 pm
All posters will be available as PDFs after they are presented on Array's website: www.arraybiopharma.com. About Inflammatory Disease Inflammation is a natural biologic response to injury or infectious attack to the human body. Unregulated inflammation results in a broad range of conditions, most of which are classified by the tissue or organ where the inflammation occurs. These conditions include rheumatoid arthritis rheumatoid arthritis Chronic, progressive autoimmune disease causing connective-tissue inflammation, mostly in synovial joints. It can occur at any age, is more common in women, and has an unpredictable course. in the joint, psoriasis in the skin, COPD COPD chronic obstructive pulmonary disease. COPD abbr. chronic obstructive pulmonary disease Chronic obstructive pulmonary disease (COPD) in the lung, fibrotic disease in the liver and kidney, Crohn's disease Crohn's disease: see colitis. in the intestine, CHF CHF In currencies, this is the abbreviation for the Swiss Franc. Notes: The currency market, also known as the Foreign Exchange market, is the largest financial market in the world, with a daily average volume of over US $1 trillion. and arteriosclerosis arteriosclerosis (ärtĭr'ēōsklərō`sis), general term for a condition characterized by thickening, hardening, and loss of elasticity of the walls of the blood vessels. in the arteries. Currently, some of the most effective treatments for these diseases are injected protein therapeutics, which have significant cost and patient compliance issues. Injectable protein therapeutics currently on the market, such as Enbrel, Remicade, Humira and Kineret, bind to and/or modulate the activity of the inflammatory cytokines Cytokines Chemicals made by the cells that act on other cells to stimulate or inhibit their function. Cytokines that stimulate growth are called "growth factors. TNF TNF abbr. tumor necrosis factor TNF, n an abbreviation for tumor necrosis f or IL-1. There remains a significant unmet medical need for improved therapies to treat COPD, asthma, fibrosis and cardiovascular diseases. We believe there is a significant opportunity to create orally active drugs to treat many of these often-chronic diseases. We are developing drugs that modulate important biological targets in key intracellular pathways that control inflammation, potentially providing the ability to treat multiple diseases with a single oral agent. According to EvaluatePharma, the worldwide market for injectable targeted therapies for rheumatoid arthritis alone is expected to grow from $10 billion in 2006 to $18 billion in 2012. Additionally, with the safety concerns over the class of pain medications known as COX-2 inhibitors Cox-2 Inhibitors Definition Cox-2 inhibitors are non-steroidal anti-inflammatory drugs (NSAIDs) which selectively inhibit cyclooxygenase-2. The cyclooxygenases are required for the creation of prostaglandins. , new markets for replacement drugs to treat pain associated with rheumatoid arthritis and osteoarthritis osteoarthritis or osteoarthrosis or degenerative joint disease Most common joint disorder, afflicting over 80% of those who reach age 70. It does not involve excessive inflammation and may have no symptoms, especially at first. are likely to develop. About ARRY-162 / MEK for Inflammation MEK is an enzyme that regulates the biosynthesis Biosynthesis The synthesis of more complex molecules from simpler ones in cells by a series of reactions mediated by enzymes. The overall economy and survival of the cell is governed by the interplay between the energy gained from the breakdown of compounds of the inflammatory cytokines TNF, IL-6 and IL-1. Array scientists have discovered potent MEK inhibitors that interfere with these biosynthetic bi·o·syn·the·sis n. Formation of a chemical compound by a living organism. Also called biogenesis. bi processes. We have previously advanced one MEK inhibitor, ARRY-886, into clinical development for the treatment of cancer. Given our experience with the safety profile of MEK inhibitors, we believe inhibition of MEK will have broad applications in diseases driven by IL-1 and TNF. ARRY-162, an orally active MEK inhibitor, has shown significant efficacy and is well tolerated in preclinical models of human arthritis and other inflammatory diseases. We initiated Phase 1 clinical testing in normal volunteers in April 2006. About ARRY-797 / p38 for Inflammation and Cancer p38 is an enzyme that regulates the production of numerous pro-inflammatory cytokines, in particular, TNF, IL-6 and IL-1. Additionally, several cancers have show up-regulation of TNF and IL-6, including prostate, ovarian and multiple myeloma multiple myeloma A malignant proliferation of abnormal plasma cells that populate the marrow-containing bones of the body. The affected plasma cells produce myeloma protein, a monoclonal antibody that replaces normal antibodies in the blood, thereby increasing susceptibility ; p38 may be involved as part of a resistance mechanism. ARRY-797, an orally active p38 inhibitor, has demonstrated significant efficacy and is well tolerated in preclinical models of human arthritis and certain cytokine-driven cancers. We initiated Phase 1 clinical testing in 2006. About Array BioPharma: Array BioPharma Inc. is a biopharmaceutical company focused on the discovery, development and commercialization of targeted small molecule drugs to treat life threatening and debilitating de·bil·i·tat·ing adj. Causing a loss of strength or energy. Debilitating Weakening, or reducing the strength of. Mentioned in: Stress Reduction diseases. Our proprietary drug development pipeline is focused on the treatment of cancer and inflammatory disease and includes clinical candidates that are designed to regulate therapeutically important targets. In addition, leading pharmaceutical and biotechnology companies collaborate with Array to discover and develop drug candidates across a broad range of therapeutic areas. For more information on Array, please go to www.arraybiopharma.com. Array BioPharma Forward-Looking Statement forward-looking statement A projected financial statement based on management expectations. A forward-looking statement involves risks with regard to the accuracy of assumptions underlying the projections. : This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act The Private Securities Litigation Reform Act of 1995 (PSLRA) implemented several significant substantive changes affecting certain cases brought under the federal securities laws, including changes related to pleading, discovery, liability, class representation and awards fees and of 1995, including statements about Array's clinical development plans and advancing Array's drug development pipeline. These statements involve significant risks and uncertainties, including those discussed in our annual report filed on form 10-K Form 10-K A report required by the SEC from exchange-listed companies that provides for annual disclosure of certain financial information. Form 10-K See 10-K. for the year ended June 30, 2006, our quarterly report on Form 10-Q for the quarter ended March 31, 2007, and in other reports filed by Array with the Securities and Exchange Commission. Because these statements reflect our current expectations concerning future events, our actual results could differ materially from those anticipated in these forward-looking statements as a result of many factors. These factors include, but are not limited to, our ability to continue to fund and successfully progress internal research efforts and to create effective, commercially viable drugs, our ability to achieve and maintain profitability, the extent to which the pharmaceutical and biotechnology industries are willing to in-license drug candidates for their product pipelines and to collaborate with and fund third parties on their drug discovery activities, our ability to out-license our proprietary candidates on favorable terms, risks associated with our dependence on our collaborators for the clinical development and commercialization of our out-licensed drug candidates, the ability of our collaborators and of Array to meet objectives tied to milestones and royalties, and our ability to attract and retain experienced scientists and management. We are providing this information as of May 30, 2007. We undertake no duty to update any forward-looking statements to reflect the occurrence of events or circumstances after the date of such statements or of anticipated or unanticipated events that alter any assumptions underlying such statements. |
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