Aradigm Issued Patent on Breath Control Technology For Effective Pulmonary Delivery of Insulin.HAYWARD, Calif.--(BW HealthWire)--Oct. 6, 1997--Aradigm Corporation (NASDAQ NASDAQ in full National Association of Securities Dealers Automated Quotations U.S. market for over-the-counter securities. Established in 1971 by the National Association of Securities Dealers (NASD), NASDAQ is an automated quotation system that reports on :ARDM) announced today that it was issued U.S. patent 5,672,581 on using breath control technology to deliver insulin through the lung. The patent covers the breath-controlled pulmonary delivery of all insulin formulations. "Breath control" means guiding the patient to the correct inspiratory in·spi·ra·to·ry adj. Of, relating to, or used for the drawing in of air. inspiratory pertaining to or used in the inspiration of air into the lungs. flow rate and automatically delivering drug at the right time in the breath. Aradigm is developing the AERx Diabetes Management This article is about the management of diabetes mellitus. For more on the disease itself see diabetes mellitus. Diabetes is a chronic disease with no cure as of 2007. It is associated with an impaired glucose cycle, altering metabolism. System, which incorporates breath control technology, so diabetics can manage their meal-time glucose using insulin, without needles. In clinical studies, Aradigm has shown that the way in which a patient breathes has a significant effect on both the time to maximum blood insulin levels and maximum blood glucose blood glucose Diabetology The principal sugar produced by the body from food–especially carbohydrates, but also from proteins and fats; glucose is the body's major source of energy, is transported to cells via the circulation and used by cells in the presence reduction after the pulmonary delivery of insulin. "Controlling how patients breathe while they take aerosolized Adj. 1. aerosolized - in the form of ultramicroscopic solid or liquid particles dispersed or suspended in air or gas aerosolised gaseous - existing as or having characteristics of a gas; "steam is water is the gaseous state" drugs is central to assuring efficient and reproducible pulmonary drug delivery. It is particularly important for a drug like insulin, where predictability of dosing is essential for safe and effective therapy," said Richard P. Thompson, Aradigm's president and chief executive officer. "This new patent is an important addition to our portfolio, which now includes 25 issued patents with more pending." In the U.S. alone, diabetes is estimated to affect 16 million people, with direct treatment costs exceeding $45 billion annually. The ability to control meal-time glucose is a key factor in reducing the risk of serious medical complications for diabetics. Currently, the invasive nature of insulin injections keeps many diabetics from properly managing their meal-time glucose levels. Moreover, diabetes treatment guidelines emphasize the importance of being able to predict how a given dose of insulin will affect blood glucose levels blood glucose level, n level of glu-cose in the bloodstream, normally about 70 to 115 mg/dL after fasting overnight. Higher levels may indicate diseases such as diabetes mellitus. . As is known from clinical experience with inhalers, patients cannot learn and retain proper breathing techniques to achieve consistent delivery of inhaled in·hale v. in·haled, in·hal·ing, in·hales v.tr. 1. To draw (air or smoke, for example) into the lungs by breathing; inspire. 2. drugs without continual feedback. The breath control technology being designed into the AERx Diabetes Management System will provide the feedback needed to achieve reproducible delivery of inhaled insulin. Located in Hayward, California Hayward is a city located in the East Bay in Alameda County. The sixth largest city in the San Francisco Bay Area, it is one of the larger suburbs of Oakland. As of the 2000 census, the city population was 140,030. The estimated population in 2007 is 155,312. , Aradigm is engaged in the development of novel, pulmonary drug delivery systems designed to enhance the delivery and effectiveness of a number of existing and development stage drugs and reduce the need for injectable in·ject·a·ble adj. Capable of being injected. Used of a drug. n. A drug or medicine that can be injected. drug therapy. Aradigm plans to commercialize its proprietary technologies on two product platforms; the SmartMist Respiratory Management System, which is designed to improve the effectiveness of treatment provided by metered dose inhalers; and the AERx Pulmonary Drug Delivery System, which creates aerosols from liquid drug formulations for delivery locally to the lung or into the bloodstream via the lung. -0- Except for the historical information contained herein, this news release contains forward looking statements that involve risk and uncertainties, including the timely availability and acceptance of new products, the impact of competitive products and pricing, and the management of growth, as well as the other risks detailed from time to time in Aradigm Corporation's Securities and Exchange Commission (SEC) Registration Statements, including the company's Annual Report on Form 10-K Form 10-K A report required by the SEC from exchange-listed companies that provides for annual disclosure of certain financial information. Form 10-K See 10-K. filed with the SEC on March 28, 1997. CONTACT: Aradigm Corp. Richard P. Thompson, 510/783-0100 or Burns McClellan Audra Nass, 415/352-6262 (Media) Ruth Markowitz, 212/213-0006 (Investors) |
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