ArQule, Inc. to Present at UBS Global Life Sciences Conference on September 21, 2009.WOBURN, Mass. -- ArQule, Inc. (Nasdaq: ARQL) today announced that it will present at the UBS Global Life Sciences Conference on Monday, September 21, 2009 at 10:30 a.m. eastern time. ArQule's presentation will be web cast live and can be accessed through the investor relations section of the Company's website, www.arqule.com. The conference will be held at the Grand Hyatt Hotel, New York. About ArQule ArQule is a biotechnology company engaged in the research and development of next-generation, small-molecule cancer therapeutics. The Company's targeted, broad-spectrum products and research programs are focused on key biological processes that are central to cancer. ArQule's lead product, in Phase 2 clinical development, is ARQ 197, an inhibitor of the c-MET receptor tyrosine kinase Receptor tyrosine kinases (RTK)s are the high affinity cell surface receptors for many polypeptide growth factors, cytokines and hormones. Of the ninety unique tyrosine kinase genes idenitified in the human genome, 58 encode receptor tyrosine kinase proteins. . The Company has also initiated Phase 1 clinical testing with ARQ 621, designed to inhibit the Eg5 kinesin motor protein. An additional clinical-stage program includes compounds that activate the cell's DNA DNA: see nucleic acid. DNA or deoxyribonucleic acid One of two types of nucleic acid (the other is RNA); a complex organic compound found in all living cells and many viruses. It is the chemical substance of genes. damage response mechanism mediated by the E2F-1 transcription factor. The Company's pre-clinical pipeline includes a compound designed to inhibit the BRAF BRAF Baton Rouge Area Foundation BRAF Bookstore Requisition Attachment Form (USF) kinase. ArQule's current discovery efforts, which are based on the ArQule Kinase Inhibitor Platform (AKIP[TM]) are focused on the identification of novel kinase inhibitors that are potent, selective and do not compete with ATP ATP: see adenosine triphosphate. ATP in full adenosine triphosphate Organic compound, substrate in many enzyme-catalyzed reactions (see catalysis) in the cells of animals, plants, and microorganisms. (adenosine triphosphate triphosphate /tri·phos·phate/ (tri-fos´fat) a salt containing three phosphate radicals. tri·phos·phate n. A salt or ester containing three phosphate groups. ) for binding to the kinase. |
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