Applied Research Systems obtains United States patent.Applied Research Systems ARS Holding N.V. (Curacao, Netherlands) has patented a method for improving homogeneity and/or secretion of a recombinant protein recombinant protein Molecular biology A protein encoded by recombinant DNA or generated from a recombinant gene. See Recombinant pharmacology. of interest expressed in mammalian cells by replacing the endogenous signal peptide A signal peptide is a short (3-60 amino acids long) peptide chain that directs the post-translational transport of a protein. Signal peptides may also be called targeting signals, signal sequences, transit peptides, or localization signals. sequence of the DNA DNA: see nucleic acid. DNA or deoxyribonucleic acid One of two types of nucleic acid (the other is RNA); a complex organic compound found in all living cells and many viruses. It is the chemical substance of genes. encoding the protein of interest with that of human hGH. Specifically, the present invention relates to a method wherein the protein of interest is a subunit of the follicle stimulating hormone Follicle stimulating hormone (FSH) A hormone that stimulates the growth and maturation of mature eggs in the ovary. Mentioned in: Polycystic Ovary Syndrome, Premature Menopause . The invention also relates to DNA expression vectors containing the sequence encoding such proteins of interest fused to the signal peptide sequence of the hGH and to cells harbouring such vectors. (US 7,282,352) |
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