Applied Biosystems Announces Enhancements to the Celera Discovery System and New Academic Subscription Model.Business Editors/Health/Medical Writers BIOWIRE2K FOSTER CITY, Calif.--(BUSINESS WIRE)--Jan. 28, 2003 Applied Biosystems Applied Biosystems, Inc. (formerly NASDAQ: ABIO) is the original name of a pioneer biotechnology company founded in 1981 in Foster City, California, among the Silicon Valley cities of the southern San Francisco Bay Area. Group (NYSE NYSE See: New York Stock Exchange :ABI Abi (ā`bī) [short for Abijah], in the Bible, King Hezekiah's mother. (Application Binary Interface) A specification for a specific hardware platform combined with the operating system. ) -- Updates Include Enhanced Viewer and High-Throughput Sequence Analysis Tools for Comparative Genomics Comparative genomics is the study of relationships between the genomes of different species or strains. Comparative genomics is an attempt to take advantage of the information provided by the signatures of selection to understand the function and evolutionary processes that act on , Integration of Additional Public and Proprietary Genomic Data, and an Individual Subscription Model for Academic Researchers Applied Biosystems Group (NYSE:ABI) an Applera Corporation business, today announced a new release of the Celera Discovery System(TM) (CDS) online platform that includes enhanced visualization and analysis tools for comparing the human and mouse genomes, additional data integration, and a new subscription model for academic researchers. "The latest enhancements to CDS should enable subscribers to more easily apply comparative genomics to their discovery process and to better understand the roles of genes in the context of evolutionary conservation," said Deborah Smeltzer, Vice President of the Knowledge Business for Applied Biosystems. "Applied Biosystems and Celera Genomics have made significant investments in data aggregation, validation, curation Cu`ra´tion n. 1. Cure; healing. , classification, quality assurance, and have further integrated public reference data. We believe our subscribers will save time and costs through online access to an integrated set of high-quality data and analysis tools that eliminate the need for data infrastructure development and maintenance." New subscriptions to the Celera Discovery System online platform will now be available to researchers at academic and non-profit institutions through a single-user, one-year subscription agreement. These researchers can easily begin the subscription process online through the CDS website, available at http://www.celeradiscoverysystem.com. Applied Biosystems and Celera Genomics are collaborating to integrate Celera's genomic and biological information with Applied Biosystems' products and services. CDS subscribers can now order the Applied Biosystems Assays-on-Demand(TM) products, ready-to-use, functionally validated assays for genotyping Genotyping refers to the process of determining the genotype of an individual with a biological assay. Current methods of doing this include PCR, DNA sequencing, and hybridization to DNA microarrays or beads. and gene expression analysis, within the context of their analysis results using CDS. The new release of CDS includes an updated interactive Map Viewer, which provides enhanced and customizable graphical displays for comparing human and mouse genes within their genomic context. The Map Viewer also now enables subscribers to conduct BLAST searches in batch mode and to customize views of data from the entire chromosome to the single nucleotide level. These enhancements are intended to facilitate high-throughput analysis and should enable subscribers to analyze biological relationships within any region of the human or mouse genomes. Additional Enhancements: -- Pre-computed human-mouse ortholog pairs displayed with synteny information and neighboring genes. -- The first release of annotated mouse genes, hand-curated by scientists from Celera Genomics. -- Annotation of human gene regulatory regions through mapping of transcription factor binding sites. -- Panther Universal Protein Library 3.1 protein classifications, which now contain 4,000 additional protein families and 12,000 subfamilies, providing more comprehensive functional predictions. -- Key literature references pertaining to the structure and function of genes and their products. -- An upgraded set of sequence analysis tools for data comparison, manipulation, and protein prediction. -- Links to the Human Gene Mutation Database (HGMD), Online Mendelian Inheritance in Man (OMIM), Swiss-Prot and LocusLink databases. About the Celera Discovery System Online Platform (CDS) CDS is a web-based discovery platform that provides scientists with access to a comprehensive source of integrated, curated and validated proprietary and public biological data, including annotated human and mouse genomes. In April 2002, Celera Genomics and Applied Biosystems entered into a marketing and distribution agreement under which Applied Biosystems became the exclusive marketer of CDS and related information assets. More than 250 institutions worldwide currently subscribe to Verb 1. subscribe to - receive or obtain regularly; "We take the Times every day" subscribe, take buy, purchase - obtain by purchase; acquire by means of a financial transaction; "The family purchased a new car"; "The conglomerate acquired a new company"; CDS, including pharmaceutical and biotechnology companies Top 100 Biotechnology Companies The following is a list of the top 100 biotechnology companies ranked by revenue. The first nine companies qualify for the list of the top 50 pharmaceutical companies. , as well as academic organizations. About Applera Corporation and Applied Biosystems Applera Corporation comprises two operating groups. The Applied Biosystems Group develops and markets instrument-based systems, reagents, software, and contract services to the life science industry and research community. Customers use these tools to analyze nucleic acids Nucleic acids The cellular molecules DNA and RNA that act as coded instructions for the production of proteins and are copied for transmission of inherited traits. (DNA DNA: see nucleic acid. DNA or deoxyribonucleic acid One of two types of nucleic acid (the other is RNA); a complex organic compound found in all living cells and many viruses. It is the chemical substance of genes. and RNA RNA: see nucleic acid. RNA in full ribonucleic acid One of the two main types of nucleic acid (the other being DNA), which functions in cellular protein synthesis in all living cells and replaces DNA as the carrier of genetic ), small molecules, and proteins to make scientific discoveries, develop new pharmaceuticals, and conduct standardized testing A standardized test is a test administered and scored in a standard manner. The tests are designed in such a way that the "questions, conditions for administering, scoring procedures, and interpretations are consistent" [1] . Applied Biosystems is headquartered in Foster City, CA, and reported sales of $1.6 billion during fiscal 2002. The Celera Genomics Group, located in Rockville, MD, and South San Francisco South San Francisco, city (1990 pop. 54,312), San Mateo co., W Calif.; inc. 1908. South San Francisco has several industrial parks; its manufactures include medical supplies and equipment, foods, paint, paper products, consumer goods, and clothing. , CA, is engaged principally in integrating advanced technologies to discover and develop new therapeutics. Celera intends to leverage its proteomic, bioinformatic, and genomic capabilities to identify and validate drug targets and diagnostic marker candidates, and to discover and develop new therapeutics. Its Celera Discovery System(TM) online platform, marketed exclusively through the Applied Biosystems Knowledge Business, is an integrated source of information based on the human genome The human genome is the genome of Homo sapiens, which is composed of 24 distinct pairs of chromosomes (22 autosomal + X + Y) with a total of approximately 3 billion DNA base pairs containing an estimated 20,000–25,000 genes. and other biological and medical sources. Celera Diagnostics, a 50/50 joint venture between Applied Biosystems and Celera Genomics, is focused on discovery, development, and commercialization of novel diagnostics products. Information about Applera Corporation, including reports and other information filed by the company with the Securities and Exchange Commission, is available on the World Wide Web at http://www.applera.com, or by telephoning 800/762-6923. Information about Applied Biosystems is available on the World Wide Web at http://www.appliedbiosystems.com. Certain statements in this press release are forward-looking. These may be identified by the use of forward-looking words or phrases such as "should," and "intend" among others. These forward-looking statements forward-looking statement A projected financial statement based on management expectations. A forward-looking statement involves risks with regard to the accuracy of assumptions underlying the projections. are based on Applera Corporation's current expectations. The Private Securities Litigation Reform Act The Private Securities Litigation Reform Act of 1995 (PSLRA) implemented several significant substantive changes affecting certain cases brought under the federal securities laws, including changes related to pleading, discovery, liability, class representation and awards fees and of 1995 provides a "safe harbor Safe Harbor 1. A legal provision to reduce or eliminate liability as long as good faith is demonstrated. 2. A form of shark repellent implemented by a target company acquiring a business that is so poorly regulated that the target itself is less attractive. " for such forward-looking statements. In order to comply with the terms of the safe harbor, Applera Corporation notes that a variety of factors could cause actual results and experience to differ materially from the anticipated results or other expectations expressed in such forward-looking statements. These factors include but are not limited to: (1) rapidly changing technology could adversely affect demand for Applied Biosystems' products, and its business is dependent on development of new products; (2) uncertainty of successful integration of the Celera Discovery System(TM) online platform into the Applied Biosystems Knowledge Business and market acceptance and adoption of Knowledge Business product offerings; (3) Applied Biosystems' sales are dependent on customers' capital spending capital spending Spending for long-term assets such as factories, equipment, machinery, and buildings that permits the production of more goods and services in future years. policies and government-sponsored research; (4) the Applied Biosystems Knowledge Business' dependence on the operation of computer hardware, software, and Internet applications and related technology; (5) unproven unproven Dubious, nonscientific, not proven, quack, questionable, unscientific adjective Relating to that which has not been validated by reproducible experiments or other scientific methods for determining effect or efficacy use of genomics information to develop products, and (6) other factors that might be described from time to time in Applera Corporation's filings with the Securities and Exchange Commission. All information in this press release is as of the date of the release, and Applera does not undertake any duty to update this information, including any forward-looking statements, unless required by law. Note to Editors: Applied Biosystems is a registered trademark and Applera, Assays-on-Demand, Celera, Celera Diagnostics, Celera Discovery System and Celera Genomics are trademarks of Applera Corporation or its subsidiaries in the U.S. and certain other countries. |
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