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Applied Biosystems/MDS SCIEX to Showcase Speed, Throughput and Confidence of Mass Spectrometry at International Industry Conference.



INDIANAPOLIS -- Mass spectrometry continues to gain widespread use for life sciences applications. In the past, access to this technology was primarily through core mass spectrometry laboratories run by highly trained specialists. With newer technology, the speed and accuracy of mass spectrometry is becoming available for an expanding list of applications including drug discovery, biomarker research, food contaminant contaminant /con·tam·i·nant/ (kon-tam´in-int) something that causes contamination.

contaminant

something that causes contamination.
 testing and forensic toxicology. Applied Biosystems (NYSE NYSE

See: New York Stock Exchange
: ABI Abi (ā`bī) [short for Abijah], in the Bible, King Hezekiah's mother.


(Application Binary Interface) A specification for a specific hardware platform combined with the operating system.
), an Applera Corporation business, and its joint venture partner, Sciex, a division of MDS MDS,
n See temporomandibular pain-dysfunction syndrome.

MDS 1 Maternal deprivation syndrome, see there 2 Myelodysplastic syndrome, see there
 Inc.'s Analytical Technologies business, (NYSE: MDZ MDZ Mendez
MDZ Moskauer Deutsche Zeitung (Moscow German newspaper)
MDZ Maritime Defense Zone
MDZ Musik Der Zukunft (music label & community)
MDZ Mendoza, Mendoza, Argentina - El Plumerillo
, TSX TSX Toronto Stock Exchange (TSE before April, 2002)
TSX Transfer from Stack Pointer to Index
TSX True Space Extension
: MDS), will showcase many of these new applications during the 55th annual American Society of Mass Spectrometry (ASMS ASMS American Society for Mass Spectrometry
ASMS Association of Salaried Medical Specialists
ASMS Advanced Satellite Mobile Systems
ASMS Alabama School of Mathematics and Science
ASMS American Society for Mohs Surgery
ASMS Arkansas School for Math and Science
) conference in Indianapolis, June 3-7.

More than 100 presentations highlighting significant research conducted on Applied Biosystems/MDS SCIEX instrument systems will be delivered during the conference. These presentations will detail innovative mass spectrometry-based applications for diverse fields such as clinical research, drug candidate screening, drug distribution imaging in animal tissues, proteomics, and contaminant detection in groundwater or food.

Among the highlights, data will be presented by University of Cincinnati The University of Cincinnati is a coeducational public research university in Cincinnati, Ohio. Ranked as one of America’s top 25 public research universities and in the top 50 of all American research universities,[2]  and University of Geneva The University of Geneva (Université de Genève) is a university in Geneva, Switzerland. It was founded by John Calvin in 1559. Initially a theological seminary, it also taught law.  researchers who have had early experience with Applied Biosystems/MDS SCIEX's recently-announced FlashQuant(TM) Workstation for ultra-fast quantitation of drug compounds and their metabolites. The investigators evaluated the technology for potential use in high throughput drug discovery screening assays and therapeutic drug monitoring therapeutic drug monitoring Clinical pharmacology The regular measurement of serum levels of drugs requiring close 'titration' of doses in order to ensure that there are sufficient levels in the blood to be therapeutically effective, while avoiding potentially  studies, respectively. The new platform is expected to be the first commercially available system to combine an industry-standard triple quadrupole A quadrupole is one of a sequence of configurations of electric charge or gravitational mass that can exist in ideal form, but it is usually just part of a multipole expansion of a more complex structure reflecting various orders of complexity.  mass spectrometry with MALDI MALDI Matrix-Assisted Laser Desorption/Ionization  technology to deliver an unparalleled level of speed in drug compound screening.

Results being presented will demonstrate the feasibility of applying FlashQuant to high throughput screening (HTS HTS Heights
HTS Harmonized Tariff System
HTS High Throughput Screening (biomolecular assay screening)
HTS High-Throughput Screening (Pharmaceutical Industry)
HTS Harmonized Tariff Schedule
). One advantage of this technology is the ability to directly measure analytes instead of relying upon fluorescent and chemilluminescent indicators, according to the investigators. FlashQuant's analytical time in the studies of one to two seconds per sample approaches the speed achieved in traditional HTS assays.

The conference will also feature a presentation by scientists from the Mayo Clinic, based in Rochester, Minn., who will present data on their research collaboration with Applied Biosystems/MDS SCIEX scientists to develop methods for the rapid measurement of amino acids in human plasma. Amino acid analysis is commonly used for determining inborn inborn /in·born/ (in´born?)
1. genetically determined, and present at birth.

2. congenital.


in·born
adj.
1. Possessed by an organism at birth.

2.
 errors of metabolism in infants. By applying Applied Biosystems' iTRAQ[R] reagents and mass spectrometers to this test, the scientists were able to reduce the analytical time to less than one-sixth of the time required by traditional methods, for increased throughput and reduced time to deliver test results.

Pediatrix Analytical and Sciex will also present data on their research to develop a new method for measuring thyroxin Thyroxin
The hormone secreted by the thyroid gland.

Mentioned in: Goiter


thyroxine, thyroxin

a hormone of the thyroid gland that contains iodine and is a derivative of the amino acid tyrosine.
 (T4) and thyroid stimulating hormone Thyroid stimulating hormone (thyrotropin)
A hormone that stimulates the thyroid gland to produce hormones that regulate metabolism.

Mentioned in: Pituitary Dwarfism
 (TSH TSH thyroid-stimulating hormone; see thyrotropin.

TSH
abbr.
thyroid-stimulating hormone


Thyroid-stimulating hormone (TSH) 
) from filter paper blood spots. Typically performed on newborns to screen for congenital hypothyroidism, the new method holds promise to be a cost-effective and efficient alternative to the standard immunoassay method.

Several other presentations will detail research results derived by scientists using BioMAP, a software program developed for biomedical imaging and commercially licensed in the field of mass spectrometry exclusively to Applied Biosystems. The BioMAP software application provides processing and display capabilities for mapping the distribution of drugs, metabolites, peptides and proteins in tissue via mass spectrometry imaging Mass spectrometry imaging (also known as imaging mass spectrometry) is a technique used in mass spectrometry to visualize the spatial distribution of e.g. compounds, biomarker, metabolites, peptides or proteins by their molecular masses. . This technology has been shown to hold great promise for the life-sciences industry based upon animal studies that demonstrate in photo-like images, how drugs are distributed and metabolized within an animal or tissue.

The FlashQuant System will be on display at Booth #66 and in rooms 143-144 and 147-148 at the convention center, along with a variety of Applied Biosystems/MDS SCIEX technologies, including:

* 4800 Plus MALDI TOF/TOF[TM] Analyzer, a new system for proteomics analysis that can identify thousands of proteins in a biological sample, providing an improved platform to better support the larger sample studies that proteomics researchers are pursuing,

* ProteinPilot[TM] Software designed to maximize the information that can be obtained from the combination of the 4800 Plus and Applied Biosystems iTRAQ reagents for more accurate protein detection, easier manageability and broader support for quantitation.

"The science being highlighted during this conference demonstrates the rapidly expanding applications for mass spectrometry that scientists can apply to their research," said Laura Lauman, president for Applied Biosystems' proteomics and small molecules division. "Added speed, throughput and confidence in mass spectrometry are delivering more efficient, more productive research across the life sciences spectrum."

OTHER ASMS HIGHLIGHTS:

Applied Biosystems/MDS SCIEX Annual Users Meeting

Drawing more than 1,000 attendees annually, the Applied Biosystems/MDS SCIEX annual users meeting is scheduled for Sunday, June 3, 2007. Leaders from industry, academia, and Applied Biosystems/MDS SCIEX will discuss the applications of mass spectrometry in advanced workflows for drug discovery and development, protein biomarker discovery and validation, metabolomics, food safety testing, environmental analysis, and clinical research, among others.

Keynote speakers include:

* Marcel Hop, senior director, Pfizer Pharmaceuticals, on the topic of High Throughput ADME ADME Absorption, Distribution, Metabolism, and Excretion
ADME Association of Destination Management Executives
ADME Active Duty Medical Extension
 Screening - The Case for Corporate and Vendor Commitment

* Timothy V. Olah, director, Bioanalytical Research, Bristol-Myers Squibb on Quantitative LC-MS/MS-Based Bioanalysis to Support Drug Discovery

Other invited speakers include Anthony D. Whetton, Cancer and Imaging Research School, University of Manchester The University of Manchester is a university located in Manchester, England. With over 40,000 students studying 500 academic programmes, more than 10,000 staff and an annual income of nearly £600 million it is the largest single-site University in the United Kingdom and receives , Christie Hospital, UK; Mark P. Molloy, Australian Proteome pro·te·ome
n.
The complete set of proteins that are produced by the genes of an organism.



proteome

the entire complement of proteins produced by a cell.
 Analysis Facility, Macquarie University, Australia; Jarrod Marto, Cancer Biology Department, Dana Farber Cancer Institute; Richard King, Discovery Group Lead, Merck; and Robert C. Murphy Robert C. Murphy (October 9, 1926 - October 31, 2000) was a lawyer and jurist from Baltimore County, Maryland. He served as Chief Judge of the Maryland Court of Appeals, the state's highest court, from 1972 to October 1996. He was appointed by then Governor Marvin Mandel. , Dept. of Pharmacology, University of Colorado University of Colorado may refer to:
  • University of Colorado at Boulder (flagship campus)
  • University of Colorado at Colorado Springs
  • University of Colorado at Denver and Health Sciences Center
  • University of Colorado system
 Health Science Center.

About Applera Corporation and Applied Biosystems

Applera Corporation consists of two operating groups. The Applied Biosystems Group serves the life science industry and research community by developing and marketing instrument-based systems, consumables, software, and services. Customers use these tools to analyze nucleic acids (DNA DNA: see nucleic acid.
DNA
 or deoxyribonucleic acid

One of two types of nucleic acid (the other is RNA); a complex organic compound found in all living cells and many viruses. It is the chemical substance of genes.
 and RNA RNA: see nucleic acid.
RNA
 in full ribonucleic acid

One of the two main types of nucleic acid (the other being DNA), which functions in cellular protein synthesis in all living cells and replaces DNA as the carrier of genetic
), small molecules, and proteins to make scientific discoveries and develop new pharmaceuticals. Applied Biosystems' products also serve the needs of some markets outside of life science research, which we refer to as "applied markets," such as the fields of: human identity testing (forensic and paternity testing); biosecurity, which refers to products needed in response to the threat of biological terrorism and other malicious, accidental, and natural biological dangers; and quality and safety testing, for example in food and the environment. Applied Biosystems is headquartered in Foster City, CA, and reported sales of $1.9 billion during fiscal 2006. The Celera Group is primarily a molecular diagnostics business that is using proprietary genomics and proteomics discovery platforms to identify and validate novel diagnostic markers, and is developing diagnostic products based on these markers as well as other known markers. Celera maintains a strategic alliance with Abbott for the development and commercialization of molecular, or nucleic acid-based, diagnostic products, and it is also developing new diagnostic products outside of this alliance. Through its genomics and proteomics research efforts, Celera is also discovering and validating therapeutic targets, and it is seeking strategic partnerships to develop therapeutic products based on these discovered targets. Information about Applera Corporation, including reports and other information filed by the company with the Securities and Exchange Commission, is available at http://www.applera.com, or by telephoning 800.762.6923. Information about Applied Biosystems is available at http://www.appliedbiosystems.com.

About MDS Inc.

MDS Inc. (TSX: MDS; NYSE: MDZ) is a global life sciences company that provides market-leading products and services that our customers need for the development of drugs and diagnosis and treatment of disease. We are a leading global provider of pharmaceutical contract research, medical isotopes for molecular imaging, radiotherapeutics, and analytical instruments. MDS has more than 6,200 highly skilled people in 28 countries. Find out more at www.mdsinc.com or by calling 1-888-MDS-7222, 24 hours a day.

About Sciex

Sciex is a division of MDS Analytical Technologies. The Sciex product portfolio offers proven market leadership in mass spectrometry through its joint ventures with two of the world's leading analytical instrumentation and life sciences companies, Applied Biosystems, a business of the Applera Corporation and PerkinElmer Inc. Find out more at www.mdssciex.com

Applied Biosystems Forward Looking Statements

Certain statements in this press release are forward-looking. These may be identified by the use of forward-looking words or phrases such as "should," "expect," and "planned," among others. These forward-looking statements are based on Applera Corporation's current expectations. The Private Securities Litigation Reform Act The Private Securities Litigation Reform Act of 1995 (PSLRA) implemented several significant substantive changes affecting certain cases brought under the federal securities laws, including changes related to pleading, discovery, liability, class representation and awards fees and  of 1995 provides a "safe harbor" for such forward-looking statements. In order to comply with the terms of the safe harbor, Applera Corporation notes that a variety of factors could cause actual results and experience to differ materially from the anticipated results or other expectations expressed in such forward-looking statements. These factors include but are not limited to: (1) schedules subject to change that may affect the presentations mentioned in this release; (2) dependence on the development and customer acceptance of new products being presented; (3) sales dependent on customers' capital spending policies and (4) other factors that might be described from time to time in Applera Corporation's filings with the Securities and Exchange Commission. All information in this press release is as of the date of the release, and Applera does not undertake any duty to update this information, including any forward-looking statements, unless required by law.

For Research Use Only. Not for use in diagnostic procedures.

Applied Biosystems, AB (Design), Applera, iTRAQ and Celera are registered trademarks of Applera Corporation or its subsidiaries in the US and/or certain other countries. FlashQuant, MALDI TOF/TOF and ProteinPilot are trademarks of Applied Biosystems/MDS SCIEX, a joint venture between Applera Corporation and MDS Inc. Copyright(c) 2007. Applera Corporation and MDS Inc. All rights reserved.
COPYRIGHT 2007 Business Wire
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2007, Gale Group. All rights reserved. Gale Group is a Thomson Corporation Company.

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Publication:Business Wire
Date:May 31, 2007
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