Applications of vibrational spectroscopy in pharmaceutical research and development.9780470870877
Applications of vibrational spectroscopy in pharmaceutical research and development.
Ed. by Don E. Pivonka et al.
John Wiley John Wiley may refer to:
The editors (of AstraZeneca Pharmaceuticals in the US, VS Consulting in the UK, and the U. of Idaho in the US) present 15 chapters that describe applications of infrared and Raman spectroscopy Raman spectroscopy is a spectroscopic technique used in condensed matter physics and chemistry to study vibrational, rotational, and other low-frequency modes in a system. for pharmaceutical discovery and development. In the realm of drug discovery, chapters discuss sampling techniques and fiber-optic probes, application to combinatorial chemistry Combinatorial chemistry involves the rapid synthesis or the computer simulation of a large number of different but structurally related molecules. Introduction
Synthesis of molecules in a combinatorial fashion can quickly lead to large numbers of molecules. , determination of structure-activity relationships Structure-activity relationship is the traditional Practices of Medicinal chemistry which try to modify the effect or the potency of Bioactive chemical compound by modifying its Chemical structure. in molecular bonding, applications of vibrational optical activity in the pharmaceutical industry, and characterization and optimization of chemical synthesis In chemistry, chemical synthesis is purposeful execution of chemical reactions in order to get a product, or several products. This happens by physical and chemical manipulations usually involving one or more reactions. using real-time vibrational spectroscopy. For the topic of drug development, chapters are included on infrared and Raman spectroscopy for process development, analysis of pharmaceutical substances and formulated products by vibrational spectroscopy, Raman analysis of pharmaceuticals, vibrational spectroscopy of solid-state forms (principles and applications), pharmaceutical applications of chemical mapping and imaging, and terahertz spectroscopy Terahertz frequency radiation for spectroscopy is typically generated in one of three ways:
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