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Apollo Develops Topical Treatment for Psoriasis, Eliminating Need for Injections.


Sydney, Australia, Oct 17, 2006 - (JCN JCN Japan Corporate News
JCN Journal of Cognitive Neuroscience
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JCN joint communications network (US DoD) 
 Newswire) - Apollo Life Sciences (ASX ASX

See: Australian Stock Exchange
: AOP (Automatic OPerator) An IRC channel host who moderates the topics, keeps online users in check and provides help for newbies unfamiliar with IRC software (mIRC, etc.). Whenever AOPs come into the channel, they inherit operator status. ), a Sydney-based biotechnology company, is pleased to announce that its topical psoriasis treatment has outperformed current market-leading drugs in preclinical studies preclinical studies,
n.pl a term used to describe research done before a clinical study. May be laboratory or epidemiologic research.
. The cream-based treatment, which relieves symptoms without an injection, is now proceeding to Phase 2 clinical trials phase 2 clinical trial Phase 2 study. See Phase study. .

Apollo developed its proprietary formula using a Tumour Necrosis Factor Noun 1. tumour necrosis factor - a proinflammatory cytokine that is produced by white blood cells (monocytes and macrophages); has an antineoplastic effect but causes inflammation (as in rheumatoid arthritis)
TNF, tumor necrosis factor
 (TNF TNF
abbr.
tumor necrosis factor


TNF,
n an abbreviation for tumor
necrosis
f
) blocker, a protein that reduces inflammation and is used to treat psoriasis and other inflammatory diseases. The trials confirmed that Apollo's 'transdermal' technology successfully delivers large proteins, such as anti-inflammatories, through the skin. In comparison, psoriasis treatment products currently on the market must be injected.

Comparative tests found Apollo's product at least as effective as treatments offered by market leaders Enbrel, Humira and Remicade, which dominate a global TNF-blocker market estimated to be worth around US$8.5 billion, with an annual growth rate of over 30%.

Apollo's TransD(TM) technology, which takes anti-inflammatories and other substances through the skin, makes possible topical application of medications previously taken via injections or tablets, thus enabling direct treatment of affected areas. The transdermal formula also reduces side effects Side effects

Effects of a proposed project on other parts of the firm.
 by delivering the drug directly where it is needed, rather than travelling through the whole body as with injected versions.

"At the moment, people who are prescribed a TNF blocker must take injections. Apollo's treatment will be easier and less painful to apply," said Apollo's Science Director, Dr Greg Russell-Jones. "The TNF blockers currently on the market can have quite severe side effects, from serious infections and bruising to seizures and a higher risk of cancer. Because our TNF blocker is based on human proteins, we expect it will have fewer side effects."

Going forward, Apollo is considering approaches from overseas companies about developing its TNF blocker for subcutaneous delivery.

Psoriasis (pronounced sore-EYE-a-sis) is a severe skin rash that affects 3% of the western population and tens of millions of people in Asia. It occurs when the immune system immune system

Cells, cell products, organs, and structures of the body involved in the detection and destruction of foreign invaders, such as bacteria, viruses, and cancer cells. Immunity is based on the system's ability to launch a defense against such invaders.
 overreacts, leading to an over-growth of skin cells that in turn form itchy lesions. Sufferers often face a lifetime of treatment and ill health as psoriasis is rarely completely cured.

About Apollo Life Sciences Limited

Apollo Life Sciences (ASX: AOP) is a biotechnology company that has made major breakthroughs in the areas of drug delivery and expression of proteins from human cells. Apollo's combined technologies are expected to lead to more effective and lower cost therapeutics, compared to first generation protein-based drugs. For more information visit www.apollolifesciences.com.

Source: Apollo Life Sciences Limited

Contact:
Julian Elliott
Wilkinson Media
+61-4-2584-0071 / +61-2-8001-8888

Dr Greg Russell-Jones
Apollo Life Sciences
+61-2-9310-1800


Copyright [c] 2006 JCN Newswire. All rights reserved. A division of Japan Corporate News Network K.K.
COPYRIGHT 2006 Japan Corporate News Network K.K.
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2006, Gale Group. All rights reserved. Gale Group is a Thomson Corporation Company.

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Publication:JCN Newswires
Date:Oct 17, 2006
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