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Aphton Corporation Reports Third Quarter 2005 Financial Results; Conference Call Tomorrow at 9:00 am ET to Discuss Corporate Highlights and Finances.


PHILADELPHIA -- Aphton Corporation (NASDAQ NASDAQ
 in full National Association of Securities Dealers Automated Quotations

U.S. market for over-the-counter securities. Established in 1971 by the National Association of Securities Dealers (NASD), NASDAQ is an automated quotation system that reports on
: APHT APHT Advance Physical Test ) today reported financial results for the third quarter ended September 30, 2005. The company ended the third quarter with cash, cash equivalents and short-term investments of approximately $15 million.

Financial Update

Cash, cash equivalents, and short-term investments totaled approximately $15 million as of September 30, 2005, compared to $43 million at the end of the third quarter of 2004. For the three months ended September 30, 2005, Aphton's net loss applicable to common shareholders was $8.7 million, or $(0.14) per share, compared to a loss of $7.2 million, or $(0.19) per share for the same period in 2004.

In the third quarter, total operating costs operating costs nplgastos mpl operacionales  and expenses increased from $6.7 million in 2004 to $8.0 million in 2005. The increase in the quarter costs and expenses for the full three months ended September 2005 was due primarily to the inclusion of the costs associated with the operation of our wholly-owned subsidiary, Igeneon, (acquired March 24, 2005); research and development of our newly acquired product candidates, IGN IGN Ignored (Status)
IGN Institut Geographique National
IGN Ignition
IGN Instituto Geografico Nacional (Spain)
IGN Imagine Games Network
IGN In-Game Name (gaming) 
101 and IGN311; and a restructuring charge restructuring charge

The expense of reorganizing a company's operations. A restructuring charge is an infrequent expense that generally results from asset writedowns or facility closings.
. The restructuring charge of $288,000 relates to actions taken during the third quarter as part of the Company's cost-reduction program.

A live audio webcast of the conference call that will be held tomorrow, November 10, 2005 at 9:00 a.m. ET can be accessed either by telephone at:

Toll Free in the US/Canada at 1-800-322-0079; Code Aphton Corporation

Outside the U.S. at 1-973-409-9258; Code Aphton Corporation

Or via the internet at http://viavid.net/dce.aspx?sid=00002AC7.

A replay of the presentation will be available via the Company website and will begin approximately 2 hours after the conference call has concluded. The replay will be available for 14 days.

About Aphton

Aphton Corporation, headquartered in Philadelphia, Pennsylvania, is a clinical stage biopharmaceutical company focused on developing targeted immunotherapies for cancer. Aphton's products seek to empower the body's own immune system immune system

Cells, cell products, organs, and structures of the body involved in the detection and destruction of foreign invaders, such as bacteria, viruses, and cancer cells. Immunity is based on the system's ability to launch a defense against such invaders.
 to fight disease. Through the acquisition of Igeneon AG in March 2005, Aphton acquired late-stage products, IGN101, a cancer vaccine The term cancer vaccine is often used to describe a process whereby a person's immune system is coaxed into recognizing and destroying malignant cells without harming normal cells.  designed to induce an immune response immune response
n.
An integrated bodily response to an antigen, especially one mediated by lymphocytes and involving recognition of antigens by specific antibodies or previously sensitized lymphocytes.
 against EpCAM-positive tumor tumor: see neoplasm.  cells, as well as IGN311. Aphton has strategic alliances with Daiichi Pure Chemicals for the development, manufacturing and commercialization of gastrin-related diagnostic kits; and with Xoma for treating gastrointestinal and other gastrin-sensitive cancers using anti-gastrin monoclonal and other antibodies. Aphton's most advanced product, Insegia(TM), targets the hormone, gastrin gastrin /gasĀ·trin/ (gasĀ“trin) a polypeptide hormone secreted by certain cells of the pyloric glands, which strongly stimulates secretion of gastric acid and pepsin, and weakly stimulates secretion of pancreatic enzymes and gallbladder  17, in an attempt to treat gastrointestinal cancers. For more information about Aphton or its programs please visit Aphton's website at: www.aphton.com.
Aphton Corporation
                  Selected Condensed Financial Data
                (In thousands, except per share data)
                                                    Unaudited
                                                 Three Months Ended
                                                  September 30
                                              ------------------------
                                                 2005         2004
                                              -----------  -----------

Revenues                                     $         -  $         -
Total revenues

Costs and expenses:
General and administrative                         3,146          935
Research and development                           4,582        5,814
Restructuring Expense                                288
                                              ----------- -----------
Total cost and expenses                            8,016        6,749

Dividend and interest income                          93          224
Interest expense including amortized discount       (831)        (677)
Unrealized losses from investments                    23          (31)
                                              -----------  -----------
Net loss applicable to common shareholders       ($8,731)     ($7,233)
                                              ===========  ===========



Basic and diluted loss per common share      $     (0.14) $     (0.19)
                                              ===========  ===========

Shares used in computing net loss per share       60,448       37,712
                                              ===========  ===========



Safe Harbor Safe Harbor

1. A legal provision to reduce or eliminate liability as long as good faith is demonstrated.

2. A form of shark repellent implemented by a target company acquiring a business that is so poorly regulated that the target itself is less attractive.


This press release includes forward-looking statements forward-looking statement

A projected financial statement based on management expectations. A forward-looking statement involves risks with regard to the accuracy of assumptions underlying the projections.
. These forward-looking statements may be affected by the risks and uncertainties inherent in the drug development process and in Aphton's and Igeneon's business. This information is qualified in its entirety by cautionary statements and risk factor disclosure contained in Aphton's Securities and Exchange Commission filings, including Aphton's report on Form 10-K Form 10-K

A report required by the SEC from exchange-listed companies that provides for annual disclosure of certain financial information.


Form 10-K

See 10-K.
 filed with the Commission on March 16, 2005. Aphton wishes to caution readers that certain important factors may have affected, and could in the future affect, Aphton's beliefs and expectations and could cause the actual results to differ materially from those expressed in any forward-looking statement made by or on behalf of Aphton.
COPYRIGHT 2005 Business Wire
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2005, Gale Group. All rights reserved. Gale Group is a Thomson Corporation Company.

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Publication:Business Wire
Date:Nov 9, 2005
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