Aphios Corporation Awarded Japanese Patent for Phospholipid Nanosomes.WOBURN, Mass. -- Aphios Corporation today announced that it has been awarded a Japanese patent for its phospholipid phospholipid (fŏs'fōlĭp`ĭd), lipid that in its simplest form is composed of glycerol bonded to two fatty acids and a phosphate group. nanosomes technology platform. Phospholipid nanosomes are small, uniform liposomes Liposomes Aqueous compartments enclosed by lipid bilayer membranes; liposomes are also known as lipid vesicles. Phospholipid molecules consist of an elongated nonpolar (hydrophobic) structure with a polar (hydrophilic) structure at one end. manufactured utilizing SuperFluids(TM). SuperFluids(TM) are normally gases which, when compressed, exhibit enhanced solvation sol·va·tion n. Any of a class of chemical reactions, such as the formation of hydrated copper sulfate in aqueous solution, in which solute and solvent molecules combine with relatively weak covalent bonds. , penetration and expansive properties. These fluids are reverse-engineered to form phospholipid nanosomes for encapsulating and improving the delivery of proteins, peptides and genes as well as small molecule therapeutics. Dr. Castor, the inventor of this technology platform, points out, "This technology does not utilize organic solvents that could be harmful to the product, the recipient and/or the environment and is rapid, broadly-applicable and scalable while enhancing drug delivery." Phospholipid nanosomes are nanometer-sized vesicles of phospholipid bilayers comprised of single or multiple lipid bilayers. As such, they are non-toxic, non-antigenic and biodegradable in character since they have the molecular characteristics of mammalian cell membranes. Hydrophilic hydrophilic /hy·dro·phil·ic/ (-fil´ik) readily absorbing moisture; hygroscopic; having strongly polar groups that readily interact with water. hy·dro·phil·ic adj. compounds and therapeutics such as recombinant proteins are encapsulated in the aqueous core while hydrophobic compounds and therapeutics such as anticancer and other water-insoluble drugs are trapped within the lipid bilayers. Encapsulation masks the hydrophobic (water-insoluble) nature of drugs, and permits aqueous, biocompatible biocompatible /bio·com·pat·i·ble/ (-kom-pat´i-b'l) being harmonious with life; not having toxic or injurious effects on biological function. formulations to be administered. Phospholipid nanosomes protect the encapsulated therapeutics prolonging their circulation and increasing half-life. For cancer chemotherapy, this increases the likelihood that the drug will reach and destroy cancer cells. Encapsulation also protects cells from the circulating therapeutics and reduces their toxicities. Phospholipid nanosomes could lead to: (i) enhancement of therapeutic efficacy; (ii) elimination of pre-medication to counteract toxic excipients excipients, n.pl all the constituents of a remedy that lack medicinal properties. See also adjuvant, auxiliary substance, and vehicle. such as castor oil castor oil, yellowish oil obtained from the seed of the castor bean. The oil content of the seeds varies from about 20% to 50%. After the hulls are removed the seeds are cold-pressed. ; (iii) reduction of drug toxicity side effects; (iv) prolongation of circulation time and therapeutic effect; and (v) improvement in quality of life. Aphios Corporation (www.aphios.com) is a biopharmaceutical company that is developing enhanced natural therapeutics and biologics for health maintenance, disease prevention and the treatment of human diseases with a focus on infectious diseases, oncology and quality-of-life medicines. |
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