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Antithyroid drug lowers mortality in alcoholic liver disease.

Antithyroid Drug Lowers Mortality in Alcoholic Liver Disease

TORONTO, ONTARIO - Propylthiouracil, a drug used by patients with overactive thyroids, appears to protect alcoholics from the worst ravages of liver disease, according to a recent study by researchers from Toronto's Addiction Research Foundation and the University of Toronto.

The 310 patients in the study were heavy drinkers with clinical or laboratory evidence of liver disease who either consumed over 80 grams of alcohol daily or consistently engaged in spree drinking that left them inebriated for long periods of time. Patients treated with daily doses of 300 milligrams of propylthiouracil had half the overall mortality rate of the group that received a placebo though nearly 40% of all subjects continued to drink moderately throughout the study. But monitoring of alcohol intake throughout the study showed that protection by the drug was markedly reduced by excessive alcohol consumption.
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Title Annotation:propylthiouracil
Publication:Nutrition Health Review
Date:Jun 22, 1989
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