Antigen presenting cells; from mechanisms to drug development.9783527311088 Antigen presenting cells; from mechanisms to drug development. Ed. by Harald Kropshofer and Anne B. Vogt. Wiley-VCH 2005 611 pages $240.00 Hardcover QR185 This handbook highlights recent evidence that antigen presenting cells (APCs) are critical regulators in the interplay between the innate and adaptive aspects of the human immune system immune system Cells, cell products, organs, and structures of the body involved in the detection and destruction of foreign invaders, such as bacteria, viruses, and cancer cells. Immunity is based on the system's ability to launch a defense against such invaders. . The handbook is structured in a way to allow access to a broad readership of biochemists, immunologists, and scientists with experience in drug development. Coverage encompasses basic introductory aspects through details for advanced specialists, with material on all cell types involved in antigen presentation Antigen presentation is a process in the body's immune system by which macrophages, dendritic cells and other cell types capture antigens and then enable their recognition by T-cells. . Chapters are in sections on antigen presentation in the immune system, molecular mechanisms of antigen processing Antigen processing is a biological process that prepares antigens for presentation to special cells of the immune system called T lymphocytes. This process involves two distinct pathways for processing of antigens from an organism's own (self) proteins or intracellular pathogens (e. , antigen presenting cells' ligands recognized by T- and Toll-like receptors Toll-like receptors (TLRs) are a class of single membrane-spanning non-catalytic receptors that recognize structurally conserved molecules derived from microbes once they have breached physical barriers such as the skin or intestinal tract mucosa, and activate immune cell , the repertoire of antigen presenting cells, and antigen presenting cells as drug targets. A glossary is included. Kropshofer and Vogt work in immunology immunology, branch of medicine that studies the response of organisms to foreign substances, e.g., viruses, bacteria, and bacterial toxins (see immunity). Immunologists study the tissues and organs of the immune system (bone marrow, spleen, tonsils, thymus, lymphatic at F. Hoffman-La Roche. ([c]20062005 Book News, Inc., Portland, OR) |
|
||||||||||||||||
Printer friendly
Cite/link
Email
Feedback
Reader Opinion