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Antibacterial agents in composite restorations for the prevention of dental caries.


Antibacterial agents in composite restorations for the prevention of dental caries

When tooth decay (caries) has caused a cavity in a tooth a range of materials can be used as fillings. These include resin composite, glass ionomer cement glass ionomer cement (īon´m , amalgam and compomers. Secondary caries (tooth decay that may appear near or underneath a filling at a later stage) is a common concern in dental practice and may reduce the life span of these fillings. Antibacterial agents may be incorporated in some dental fillings i.e. resin composites to help prevent the development of secondary caries. This review failed to find any trials supporting or refuting the effectiveness of antibacterial agents incorporated into composite restorations to prevent dental caries. The authors concluded that future research should aim to provide evidence for clinicians to make informed decisions about whether antibacterial agents are effective in improving clinical outcomes in composite restorations and that further randomised Adj. 1. randomised - set up or distributed in a deliberately random way

irregular - contrary to rule or accepted order or general practice; "irregular hiring practices"
 controlled trials should be well designed and reported according to the Consolidated Standards of Reporting Trials CONSORT Statement
CONSORT stands for Consolidated Standards Of Reporting Trials. It encompasses various initiatives developed by the CONSORT Group to alleviate the problems arising from inadequate reporting of randomized controlled trials.
 (CONSORT) Statement.

Cochrane Database of Systematic Reviews 2010 Issue 11, Art. No.: CD007819. DOI (Digital Object Identifier) A method of applying a persistent name to documents, publications and other resources on the Internet rather than using a URL, which can change over time. : 10.1002/14651858.CD007819.pub2 Copyright [C] 2010 The Cochrane Collaboration. Published by John Wiley and Sons, Ltd.



Dental caries is a multifactorial disease in which the fermentation of food sugars by bacteria from the biofilm Biofilm

An adhesive substance, the glycocalyx, and the bacterial community which it envelops at the interface of a liquid and a surface. When a liquid is in contact with an inert surface, any bacteria within the liquid are attracted to the surface and adhere
 (dental plaque) leads to localised demineralisation Noun 1. demineralisation - abnormal loss of mineral salts (especially from bone)

pathology - any deviation from a healthy or normal condition
 of tooth surfaces, which may ultimately result in cavity formation. Resin composites are widely used in dentistry to restore teeth. These restorations can fail for a number of reasons, such as secondary caries, excessive wear, marginal degradation, tooth sensitivity, pulpal death, and restorative material fracture. Caries adjacent to restorations is one of the main causes for restoration replacement. The presence of antibacterials in both the filling material and the bonding systems would theoretically be able to affect the initiation and progression of caries adjacent to restorations.


To assess the effects of antibacterial agents incorporated into composite restorations for the prevention of dental caries.

Search strategy

We searched the following databases in February 2009: the Cochrane Oral Health Group's Trials Register; the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2009, Issue 1); MEDLINE The online medical database of the U.S. National Library of Medicine (NLM) whose parent is the National Institutes of Health, Bethesda, MD. MEDLINE contains millions of articles from thousands of medical journals and publications. The consumer section of the site (http://medlineplus.  via OVID (1950 to February 2009) without filter; and EMBASE via OVID (1980 to February 2009) without filter.

Selection criteria

Randomised controlled clinical trials (RCTs) comparing resin composite restorations containing antibacterial agents with non-antibacterial containing composite restorations.

Data collection and analysis

Two review authors conducted screening of studies in duplicate and independently, and although no eligible trials were identified, the two authors had planned to extract data independently and assess trial quality using standard Cochrane Collaboration methodologies.

Main results

We retrieved 128 references to studies, none of which matched the inclusion criteria for this review and all of which were excluded.

Authors' conclusions

We were unable to identify any randomised controlled trials on the effects of antibacterial agents incorporated into composite restorations for the prevention of dental caries. The absence of high level evidence for the effectiveness of this intervention emphasises the need for well designed, adequately powered, randomised controlled clinical trials.
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Author:T., Pereira-Cenci; M.S., Cenci; Z., Fedorowicz; M.A., Marchesan
Publication:Canadian Journal of Dental Hygiene
Article Type:Author abstract
Geographic Code:1CANA
Date:Feb 1, 2011
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